1. Mesenchymal Stem Cell-Derived Exosomes Provide Neuroprotection and Improve Long-Term Neurologic Outcomes in a Swine Model of Traumatic Brain Injury and Hemorrhagic Shock
- Author
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Panpan Chang, Aaron M. Williams, Ye Xiong, Michael Chopp, Yanlu Zhang, Zheng Gang Zhang, Benjamin Buller, Umar F. Bhatti, Kiril Chtraklin, Hasan B. Alam, Vahagn C. Nikolian, Jordana F. Brown, Ihab Halaweish, and Isabel S. Dennahy more...
- Subjects
030506 rehabilitation ,Swine ,Traumatic brain injury ,Shock, Hemorrhagic ,Exosomes ,Neuroprotection ,03 medical and health sciences ,0302 clinical medicine ,Brain Injuries, Traumatic ,Neuroplasticity ,medicine ,Animals ,Preventable death ,business.industry ,Mesenchymal stem cell ,Mesenchymal Stem Cells ,Recovery of Function ,medicine.disease ,Microvesicles ,Disease Models, Animal ,Hemorrhagic shock ,Cancer research ,Neurology (clinical) ,0305 other medical science ,business ,030217 neurology & neurosurgery - Abstract
Combined traumatic brain injury (TBI) and hemorrhagic shock (HS) remains a leading cause of preventable death worldwide. Mesenchymal stem cell-derived exosomes have demonstrated promise in small animal models of neurologic injury. To investigate the effects of exosome treatment in a clinically realistic large animal model, Yorkshire swine underwent TBI and HS. Animals were maintained in shock for 2 h before resuscitation with normal saline (NS). Animals were then resuscitated either with NS (3 × volume of shed blood) or with the same volume of NS with delayed exosome administration (1 × 10 more...
- Published
- 2019
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