1. Neoplastic Pericardial Effusion: A Monocentric Retrospective Study
- Author
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Enrico Cumerlato, Elisabetta Di Liso, Floriana Nappo, Alberto Banzato, Eleonora Mioranza, G. Zago, Maria Vittoria Dieci, Valentina Guarneri, Alice Menichetti, Alessandra Bianchi, Marta Padovan, Cristina Ghiotto, Luigi Corti, Federica Miglietta, Giovanna Pintacuda, and Pierfranco Conte
- Subjects
Adult ,Male ,medicine.medical_specialty ,Pericardial effusion ,Systemic therapy ,Pericardial Effusion ,03 medical and health sciences ,0302 clinical medicine ,030502 gerontology ,Internal medicine ,Neoplasms ,Antineoplastic Combined Chemotherapy Protocols ,neoplastic pericardial effusion ,Medicine ,Pericardium ,Humans ,locoregional treatment ,prognostic factors ,systemic treatment ,Pathological ,General Nursing ,Aged ,Retrospective Studies ,Aged, 80 and over ,Performance status ,business.industry ,Hazard ratio ,Cancer ,Retrospective cohort study ,General Medicine ,Middle Aged ,medicine.disease ,Prognosis ,Anesthesiology and Pain Medicine ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Female ,0305 other medical science ,business - Abstract
Background: Neoplastic pericardial effusion (NPE) is a life-threatening condition that can worsen clinical outcome in cancer patients. The optimal management of NPE has yet to be defined because randomized studies are lacking. Objective: We report a retrospective monoinstitutional experience describing characteristics, management and prognostic factors in NPE patients. Design: We reviewed clinical, pathological, and echocardiographic features, therapeutic strategies, and outcome in NPE patients referred to our institute from August 2011 to December 2017. Measurements: Twenty-nine patients with NPE from solid tumors have been identified: 21 lung, 5 breast, and 3 other cancer patients. Results: Median age was 62 years. Most of the patients had Eastern Cooperative Oncology Group (ECOG) performance status (PS) ≥2 (69%) and a symptomatic NPE (69%). In 52% of patients NPE was detected at first diagnosis of metastatic disease, and in 20% of patients pericardium was the only site of metastases. Most of the patients (62%) received systemic therapy, 28% received combined locoregional and systemic therapy, and 10% received locoregional therapy alone. Median overall survival (OS) from NPE diagnosis was 3.9 months. Patients with PS ≥2 had worse OS than patients with better PS
- Published
- 2019