Mina Nosrati, Neda Shakour, Toktam Sahranavard, Fatemeh Sadabadi, Sara Saffar Soflaei, Hamideh Ghazizadeh, Maryam Mohammadi Bajgiran, Mohamad Reza Latifi, Mohammad Amin Mansouri, Mahmoud Ebrahimi, Mohsen Mouhebati, Seyed Hassan Mirshafee, Masoumeh Haghighi, Reza Assaran Darban, Ensieh Akbarpour, Gordon A. Ferns, Habibollah Esmaily, and Majid Ghayour-Mobarhan
Introduction: Diabetes (DM) is a type of metabolic disorder that its types are generated by collectingof genetic and environmental risk agents. Here, the association between HSPB1 polymorphism as a genetic risk factor and DM was investigated. Methods: Total 690 participants from MASHAD cohort study population were recruited into the study.Anti-HSP27-level was assessed followed by genotyping using Taqman®-probes-based assay. Anthropometric, demographic and hematological/biochemical characteristics were evaluated. Kaplan-Meier curves were utilized, while logistic regression models were used to assess the association of the genetic variant with clinical characteristics of population. Results: Finds was shown there are meaningful differences among groups of age, height, waist circumference, systolic blood pressure, FBG,TG, HDL-C, and hs-CRP, and was no big -significant difference between theexists in different HSP27 SNP in the two studied groups (with and without DM), also was no remarkable relation between genetic forms of HSPB1and T2DM. This investigation was the first research that analyzed the relationship between the genetic type of the HSPB1 gene (rs2868371) and Type 2 diabetes (DM2). In our population, the CC genotype (68.1%) had a higher prevalence versus GC (26.6%) and GG (5.3%) genotypes and the data shown that no genetic difference of HSPB1 gene polymorphism (rs2868371) was related with DM2. Conclusion: HSPB1 polymorphism, rs2868371, was not associated with type 2 diabetes mellitus.