1. A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling
- Author
-
Hummel, Michael, Berger, Hilmar, Bentink, Stefan, Klapper, Wolfram, Wessendorf, Swen, Barth, Thomas F.E., Cogliatti, Sergio B., Bernd, Heinz-Wolfram, Feller, Alfred C., Dierlamm, Judith, Hansmann, Martin-Leo, Hasenclever, Dirk, Lenze, Dido, Licheter, Peter, Kuhn, Michael, Haralambieva, Eugenia, Harder, Lana, Martin-Subero, Jose Ignacio, Pott, Christine, Rosenwald, Andreas, Ott, German, Parwaresch, Reza M., Moller, Peter, Muller-Hermelink, Hans-Konrad, Rosolowski, Maciej; Schwaenen, Carsten; Sturzenhofecker, Benjamin, Trumper, Lorenz; Stein, Harald, Siebert, Reiner, Wacker, Hans-Heinrich, Spang, Rainer; Loeffler, Markus, and Szczebanowski, Monika; Trautmann, Heiko
- Subjects
Burkitt's lymphoma -- Genetic aspects ,Genetic transcription -- Research - Abstract
A study aims to establish a molecular definition of Burkitt's lymphoma and to search for other clinically relevant subgroups of diffuse large-B-cell lymphoma, using transcriptional and genomic profiling. Results show that in mature aggressive B-cell lymphomas without a gene signature for Burkitt's lymphoma, chromosomal breakpoints at the myc locus were associated with an adverse clinical outcome.
- Published
- 2006