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Your search keyword '"Crawford, John D."' showing total 39 results
Start Over Author "Crawford, John D." Publisher massachusetts medical society
39 results on '"Crawford, John D."'

1. Brief report: a mutation in the vasopressin V-2 receptor gene in a kindred with X-linked nephrogenic diabetes insipidus

Author

Merendino, John J., Jr., Spiegel, Allen M., Crawford, John D., O'Carroll, Anne-Marie, Brownstein, Michael J., and Lolait, Stephen J.

Subjects
Diabetes insipidus -- Genetic aspects, Vasopressin -- Physiological aspects
Abstract

A defect in the gene for the vasopressin V2 receptor appears to be the cause of nephrogenic diabetes insipidus. Vasopressin is a hormone that regulates the excretion of water in the urine. Nephrogenic diabetes insipidus is a rare, inherited, X chromosome-linked disorder in which the kidneys do not respond to vasopressin. X chromosome-linked disorders primarily affect males, and females may be carriers but do not usually have the disorder. In a family study of this disease, a mother gave birth to two sons with the disease. The mother and her mother were subsequently found to be carriers of the disease. DNA analysis revealed that both of the affected boys had a mutation in the gene for the V2 receptor, which binds to vasopressin. DNA analysis also revealed that the mother and grandmother carried genes with the mutation.

Published
1993

2. Osteopenia in men with a history of delayed puberty

Author

Finkelstein, Joel S., Neer, Robert M., Biller, Beverly M.K., Crawford, John D., and Klibanski, Anne

Subjects
Bones -- Density, Puberty -- Health aspects
Abstract

Boys who experience delayed puberty may have lower bone density and a higher risk for bone fractures later in life. A study of 44 men in their mid-twenties found that the average radial (forearm) bone density of 23 men who had experienced delayed puberty was lower than that of 21 normal men. Men whose puberty had been delayed had a lower average spinal bone density than normal men, and did not have the proportional relationship between radial bone density and spinal bone density found in normal men. In other studies, the incidence of bone fractures in men with similar decreases in bone density was found to be 50 to 100% higher. Approximately 3% of all boys experience delayed puberty, and they may have an increased risk of bone fractures in adulthood. Treating these boys with male hormones may decrease their risk of bone fractures in adulthood, and may prevent the psychological and social consequences of delayed puberty.

Published
1992

7. Puberty without Gonadotropins

Author

Wierman, Margaret E., primary, Beardsworth, Donna E., additional, Mansfield, M. Joan, additional, Badger, Thomas M., additional, Crawford, John D., additional, Crigler, John F., additional, Bode, Hans H., additional, Loughlin, Jacquelyn S., additional, Kushner, David C., additional, Scully, Robert E., additional, Hoffman, William H., additional, and Crowley, William F., additional

Published
1985
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20. Isovaleric Acidemia

Author

Budd, Matthew A., primary, Tanaka, Kay, additional, Holmes, Lewis B., additional, Efron, Mary L., additional, Crawford, John D., additional, and Isselbacher, Kurt J., additional

Published
1967
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