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Objective: Recall the main elements suggesting the diagnosis of hyperimmunoglobulinemia D based on a family case of chronic urticaria., Case Report: A boy and his mother presented the same signs of urticaria, fever and joint pain. Laboratory results showed an inflammatory syndrome in both. In the child, the first manifestations occurred during the age of one year. Hyperimmunoglobulinemia D was confirmed by persistently high serum levels., Conclusion: The diagnosis of hyperimmunoglobuliemia D can be entertained in a child in a family with chronic urticaria. Fever, joint pain, digestive disorders and enlarged lymph nodes are suggestive and the diagnosis is confirmed by a clear elevation of serum IgD.

The authors study the correlation between the degree of abnormality seen on radiological examination and the extent of atrophy of the villi in 29 children suspected to have had malabsorption syndromes. The radiological signs are valid but at the present time-intestinal biopsy is the only certain diagnostic examination. Based on these observations, an attempt is made to define the indications for barium meal examination of the small intestine.