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Simple Summary: Dynamic contrast-enhanced (DCE) MRI has become a quantitative standard for assessing vascular permeability and perfusion. However, conventional pharmacokinetic (PK) modeling in DCE MRI is complex and time-consuming for dynamic MR scans with thousands of pixels per image. We have previously developed a deep learning approach using convolutional neural networks (CNN) as an efficient and accurate tool for the generation of PK parameter maps from DCE MRI of glioblastoma (GBM) mice. In the present study, the utility of this approach is further established through transfer learning between GBM-trained CNN and whole-brain radiotherapy (WBRT)-treated brain metastasis (BM) mice. The purpose of this study is to further validate the utility of our previously developed CNN in an alternative small animal model of BM through transfer learning. Unlike the glioma model, the BM mouse model develops multifocal intracranial metastases, including both contrast enhancing and non-enhancing lesions on DCE MRI, thus serving as an excellent brain tumor model to study tumor vascular permeability. Here, we conducted transfer learning by transferring the previously trained GBM CNN to DCE MRI datasets of BM mice. The CNN was re-trained to learn about the relationship between BM DCE images and target permeability maps extracted from the Extended Tofts Model (ETM). The transferred network was found to accurately predict BM permeability and presented with excellent spatial correlation with the target ETM PK maps. The CNN model was further tested in another cohort of BM mice treated with WBRT to assess vascular permeability changes induced via radiotherapy. The CNN detected significantly increased permeability parameter Ktrans in WBRT-treated tumors (p < 0.01), which was in good agreement with the target ETM PK maps. In conclusion, the proposed CNN can serve as an efficient and accurate tool for characterizing vascular permeability and treatment responses in small animal brain tumor models. [ABSTRACT FROM AUTHOR]

Single-cell RNA sequencing (RNA-seq) has been demonstrated to be a proven method for quantifying gene-expression heterogeneity and providing insight into the transcriptome at the single-cell level. When combining multiple single-cell transcriptome datasets for analysis, it is common to first correct the batch effect. Most of the state-of-the-art processing methods are unsupervised, i.e., they do not utilize single-cell cluster labeling information, which could improve the performance of batch correction methods, especially in the case of multiple cell types. To better utilize known labels for complex dataset scenarios, we propose a novel deep learning model named IMAAE (i.e., integrating multiple single-cell datasets via an adversarial autoencoder) to correct the batch effects. After conducting experiments with various dataset scenarios, the results show that IMAAE outperforms existing methods for both qualitative measures and quantitative evaluation. In addition, IMAAE is able to retain both corrected dimension reduction data and corrected gene expression data. These features make it a potential new option for large-scale single-cell gene expression data analysis. [ABSTRACT FROM AUTHOR]

Holographic microwave imaging (HMI) has been proposed for early breast cancer diagnosis. Automatically classifying benign and malignant tumors in microwave images is challenging. Convolutional neural networks (CNN) have demonstrated excellent image classification and tumor detection performance. This study investigates the feasibility of using the CNN architecture to identify and classify HMI images. A modified AlexNet with transfer learning was investigated to automatically identify, classify, and quantify four and five different HMI breast images. Various pre-trained networks, including ResNet18, GoogLeNet, ResNet101, VGG19, ResNet50, DenseNet201, SqueezeNet, Inception v3, AlexNet, and Inception-ResNet-v2, were investigated to evaluate the proposed network. The proposed network achieved high classification accuracy using small training datasets (966 images) and fast training times. [ABSTRACT FROM AUTHOR]

Simple Summary: This study investigates the latest achievements, challenges, and future research directions of deep learning techniques for lung cancer and pulmonary nodule detection. Hopefully, these research findings will help scientists, investigators, and clinicians develop new and effective medical imaging tools to improve lung nodule diagnosis accuracy, sensitivity, and specificity. Medical imaging tools are essential in early-stage lung cancer diagnostics and the monitoring of lung cancer during treatment. Various medical imaging modalities, such as chest X-ray, magnetic resonance imaging, positron emission tomography, computed tomography, and molecular imaging techniques, have been extensively studied for lung cancer detection. These techniques have some limitations, including not classifying cancer images automatically, which is unsuitable for patients with other pathologies. It is urgently necessary to develop a sensitive and accurate approach to the early diagnosis of lung cancer. Deep learning is one of the fastest-growing topics in medical imaging, with rapidly emerging applications spanning medical image-based and textural data modalities. With the help of deep learning-based medical imaging tools, clinicians can detect and classify lung nodules more accurately and quickly. This paper presents the recent development of deep learning-based imaging techniques for early lung cancer detection. [ABSTRACT FROM AUTHOR]

Uyghur is a morphologically rich and typical agglutinating language, and morphological segmentation affects the performance of Uyghur named-entity recognition (NER). Common Uyghur NER systems use the word sequence as input and rely heavily on feature engineering. However, semantic information cannot be fully learned and will easily suffer from data sparsity arising from morphological processes when only the word sequence is considered. To solve this problem, we provide a neural network architecture employing subword embedding with character embedding based on a bidirectional long short-term memory network with a conditional random field layer. Our experiments show that subword embedding can effectively enhance the performance of the Uyghur NER, and the proposed method outperforms the model-based word sequence method. [ABSTRACT FROM AUTHOR]