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Your search keyword '"Bin, Li"' showing total 2 results
2 results on '"Bin, Li"'

1. New Cadinane Sesquiterpenes from the Stems of Kadsura heteroclita

Author

Wen-Bing Sheng, Wei Wang, Yuqing Jian, Atta-ur-Rahman, Caiyun Peng, Mengru Cao, M. Iqbal Choudhary, Nuzhat Shehla, Shumaila Tasneem, Bin Li, Duan-Fang Liao, and Liang Cao

Subjects
Models, Molecular, antioxidant, Magnetic Resonance Spectroscopy, Cytochalasin H, Cell Survival, Kadsura heteroclita, Pharmaceutical Science, 01 natural sciences, Article, Antioxidants, Analytical Chemistry, lcsh:QD241-441, Tujia ethnomedicine, lcsh:Organic chemistry, sesquiterpenes, Kadsura, Cell Line, Tumor, Drug Discovery, Humans, Physical and Theoretical Chemistry, Polycyclic Sesquiterpenes, biology, Traditional medicine, Molecular Structure, Plant Stems, 010405 organic chemistry, Chemistry, Plant Extracts, Organic Chemistry, biology.organism_classification, 0104 chemical sciences, Schisandraceae, 010404 medicinal & biomolecular chemistry, Polymorphonuclear cells, Chemistry (miscellaneous), Molecular Medicine, Ethnomedicine
Abstract

As part of our continual efforts to exploit &lsquo, Tujia Ethnomedicine&rsquo, for their pharmacophoric functionalities, we herein investigated Kadsura heteroclita collected from a deep Wulin mountain area in northern Hunan province. The current study resulted in the isolation of three new sesquiterpenes: 6&alpha, 9&alpha, 15-trihydroxycadinan-4-en-3-one (1), (+)-3,11,12-trihydroxycalamenene (2), (&ndash, )-3,10,11,12-tetrahydroxy-calamenene (3), along with four known sesquiterpenes (4&ndash, 7), and a cytochalasin H (8). Their chemical structures were elucidated by 1D-, and 2D-NMR spectroscopy, and HRESI-MS, CD spectrometry. The antioxidant, and cytotoxic activities of the compounds were evaluated. Compound 8 exhibited a strong antioxidant effect with an IC50 value of 3.67 &micro, M on isolated human polymorphonuclear cells or neutrophils.

Published
2019

2. Experimental and Theoretical Investigations on the Supermolecular Structure of Isoliquiritigenin and 6-O-α-D-Maltosyl-β-cyclodextrin Inclusion Complex.

Author

Bin Li, Benguo Liu, Jiaqi Li, Huizhi Xiao, Junyi Wang, and Guizhao Liang

Subjects
*INCLUSION compounds, *SOLUBILITY, *OPTICAL spectroscopy, *X-rays, *HYDROGEN bonding, *MOLECULAR structure
Abstract

Isoliquiritigenin (ILTG) possesses many pharmacological properties. However, its poor solubility and stability in water hinders its wide applications. The solubility of bioactive compounds can often be enhanced through preparation and delivery of various cyclodextrin (CD) inclusion complexes. The 6-O-α-D-maltosyl-β-CD (G2-β-CD), as one of the newest developments of CDs, has high aqueous solubility and low toxicity, especially stable inclusion characteristics with bioactive compounds. In this work, we for the first time construct and characterize the supermolecular structure of ILTG/G2-β-CD by scanning electron microscopy (SEM), ultraviolet-visible spectroscopy (UV), Fourier transform infrared spectroscopy (FT-IR), and X-ray diffractometry (XRD). The solubility of ILTG in water at 25 °C rises from 0.003 to 0.717 mg/mL by the encapsulation with G2-β-CD. Our experimental observations on the presence of the ILTG/G2-β-CD inclusion complex are further supported by the ONIOM(our Own N-layer Integrated Orbital molecular Mechanics)-based QM/MM (Quantum Mechanics/Molecular Mechanics) calculations, typically substantiating these supermolecular characteristics, such as detailed structural assignments, preferred binding orientations, selectivity, solvent effects, interaction energies and forces of the ILTG/G2-β-CD inclusion complex. Our results have elucidated how ILTG interacts with G2-β-CD, demonstrating the primary host-guest interactions between ILTG and G2-β-CD, characterized by hydrogen bonds, hydrophobic interactions, electrostatic forces, and conformational effects, are favored for the formation of the ILTG/G2-β-CD inclusion. [ABSTRACT FROM AUTHOR]

Published
2015
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