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Ice, Cloud, and Land Elevation Satellite-2 (ICESat-2) has excellent potential for obtaining water depth information around islands and reefs. Combining the density-based spatial clustering of applications with noise algorithm (DBSCAN) and multiscale quadtree analysis, we propose a new photon-counting lidar denoising method to discard the large amount of noise in ICESat-2 data. First, the kernel density estimation (KDE) is used to preprocess the point cloud data, and a threshold is set to remove the noise photons on the sea surface. Next, the DBSCAN algorithm is used to preliminarily remove underwater noise photons. Then, the quadtree segmentation and Otsu algorithm are used for fine denoising to extract accurate bottom signal photons. Based on ICESat-2 pho-ton-counting data from six typical islands and reefs worldwide, the proposed method outperforms other algorithms in terms of denoising effect. Compared to in situ data, the determination coefficient (R2) reaches 94.59%, and the root mean square error (RMSE) is 1.01 m. The proposed method can extract accurate underwater terrain information, laying a foundation for offshore bathymetry. [ABSTRACT FROM AUTHOR]

The acquisition of high-resolution (HR) digital bathymetric models (DBMs) is crucial for oceanic research activities. However, obtaining HR DBM data is challenging, which has led to the use of super-resolution (SR) methods to improve the DBM's resolution, as, unfortunately, existing interpolation methods for DBMs suffer from low precision, which limits their practicality. To address this issue, we propose a seabed terrain feature extraction transform model that combines the seabed terrain feature extraction module with the efficient transform module, focusing on the terrain characteristics of DBMs. By taking advantage of these two modules, we improved the efficient extraction of seabed terrain features both locally and globally, and as a result, we obtained a highly accurate SR reconstruction of DBM data within the study area, including the Mariana Trench in the Pacific Ocean and the adjacent sea. A comparative analysis with bicubic interpolation, SRCNN, SRGAN, and SRResNet shows that the proposed method decreases the root mean square error (RMSE) by 16%, 10%, 13%, and 12%, respectively. These experimental results confirm the high accuracy of the proposed method in terms of reconstructing HR DBMs. [ABSTRACT FROM AUTHOR]

Polyoxometalates (POMs) exhibit unique structural characteristics and excellent physical and chemical properties, which have attracted significant attention from scholars in the fields of anticancer research and chemotherapy. Herein, we successfully synthesized and structurally characterized two novel polyoxovanadates (POVs), denoted as POVs-1 and POVs-2, where [M(1-vIM)4]2[VV4O12]·H2O (M: NiII and MnII, 1-vinylimidazole abbreviated as 1-vIM) serve as ligands. The two POVs are isomeric and consist of fundamental structural units, each comprising one [V4O12]4− cluster, two [M(1-vIM)4]2+ cations, and one water molecule. Subsequently, we evaluated the cell viability of human hepatocellular carcinoma (HepG-2) cells treated with the synthesized POVs using the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazoliumbromide) assay. And the changes in cell nucleus morphology, mitochondrial membrane potential (Δψm), and reactive oxygen species levels in HepG-2 exposed to POVs were monitored using specific fluorescent staining techniques. Both hybrid POVs showed potent inhibitory activities, induing apoptosis in HepG-2 cells along with significant mitochondria dysfunction and a burst of reactive oxygen species. Notably, the inhibitory effects of POVs-2 were more pronounced than those of POVs-1, which is primarily attributed to the different transition metal ions present. These findings underscore the intricate relationship between the metal components, structural characteristics, and the observed antitumor activities in HepG-2 cells. [ABSTRACT FROM AUTHOR]

Nanocrystalline (NC) structure can lead to the considerable strengthening of metals and alloys. Obtaining appropriate comprehensive mechanical properties is always the goal of metallic materials. Here, a nanostructured Al-Zn-Mg-Cu-Zr-Sc alloy was successfully processed by high-pressure torsion (HPT) followed by natural aging. The microstructures and mechanical properties of the naturally aged HPT alloy were analyzed. The results show that the naturally aged HPT alloy primarily consists of nanoscale grains (~98.8 nm), nano-sized precipitates (20–28 nm in size), and dislocations (1.16 × 1015 m−2), and exhibits a high tensile strength of 851 ± 6 MPa and appropriate elongation of 6.8 ± 0.2%. In addition, the multiple strengthening modes that were activated and contributed to the yield strength of the alloy were evaluated according to grain refinement strengthening, precipitation strengthening, and dislocation strengthening, and it is shown that grain refinement strengthening and precipitation strengthening are the main strengthening mechanisms. The results of this study provide an effective pathway for achieving the optimal strength–ductility match of materials and guiding the subsequent annealing treatment. [ABSTRACT FROM AUTHOR]

Melanin is a kind of dark insoluble pigment that can cause pigmentation and free-radical clearance, inducing melasma, freckles, and chloasma, affecting the quality of life of patients. Due to poor water solubility and low safety, the absorption of poorly water-soluble drugs is limited by the hinderance of a skin barrier. Therefore, it is necessary to develop new, safe, and highly efficient drugs to improve their transdermal absorption efficiency and thus to inhibit the production of melanin. To address these issues, we developed a new nicotinamide (NIC)-stabilized phloretin nanocrystals (PHL-NCs). First, NC technology significantly increased the solubility of PHL. The in vitro release results indicated that at 6 h, the dissolution of the PHL-NIC-NCs was 101.39% ± 2.40% and of the PHL-NCs was 84.92% ± 4.30%, while that of the physical mixture of the two drugs was only 64.43% ± 0.02%. Second, NIC acted not only as a stabilizer to enlarge the storage time of PHL-NIC-NCs (improved to 10-day in vitro stability) but also as a melanin transfer inhibitor to inhibit melanin production. Finally, we verified the melanin inhibition effect of PHL-NIC-NCs evaluated by the zebrafish model. It showed that 0.38 mM/L PHL-NIC-NCs have a lower tyrosinase activity at 62.97% ± 0.52% and have less melanin at 36.57% ± 0.44%. The inhibition effect of PHL-NCs and PHL-NIC-NCs was stronger compared to the positive control arbutin. In conclusion, the combination of NIC and PHL achieves better inhibition of tyrosinase and inhibition of melanin production through synergism. This will provide a direction to the subsequent development of melanin-inhibiting drugs and the combined use of pharmaceutical agents. [ABSTRACT FROM AUTHOR]

An efficient CO2 adsorbent with a hierarchically micro-mesoporous structure and a large number of amine groups was fabricated by a two-step synthesis technique. Its structural properties, surface groups, thermal stability and CO2 adsorption performance were fully investigated. The analysis results show that the prepared CO2 adsorbent has a specific hierarchically micro-mesoporous structure and highly uniformly dispersed amine groups that are favorable for the adsorption of CO2. At the same time, the CO2 adsorption capacity of the prepared adsorbent can reach a maximum of 3.32 mmol-CO2/g-adsorbent in the actual flue gas temperature range of 303–343 K. In addition, the kinetic analysis results indicate that both the adsorption process and the desorption process have rapid adsorption/desorption rates. Finally, the fitting of the CO2 adsorption/desorption experimental data by Avrami's fractional kinetic model shows that the CO2 adsorption rate is mainly controlled by the intra-particle diffusion rate, and the temperature has little effect on the adsorption rate. [ABSTRACT FROM AUTHOR]