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Microsatellite instability (MSI)/defective DNA mismatch repair (dMMR) is receiving more attention as a biomarker for eligibility for immune checkpoint inhibitors in advanced diseases. However, due to high costs and resource limitations, MSI/dMMR testing is not widely performed. Some attempts are in progress to predict MSI/dMMR status through histomorphological features on H&E slides using artificial intelligence (AI) technology. In this study, the potential predictive role of this new methodology was reviewed through a systematic review. Studies up to September 2021 were searched through PubMed and Embase database searches. The design and results of each study were summarized, and the risk of bias for each study was evaluated. For colorectal cancer, AI-based systems showed excellent performance with the highest standard of 0.972; for gastric and endometrial cancers they showed a relatively low but satisfactory performance, with the highest standard of 0.81 and 0.82, respectively. However, analyzing the risk of bias, most studies were evaluated at high-risk. AI-based systems showed a high potential in predicting the MSI/dMMR status of different cancer types, and particularly of colorectal cancers. Therefore, a confirmation test should be required only for the results that are positive in the AI test. [ABSTRACT FROM AUTHOR]

Intertidal seagrass plays a vital role in estimating the overall health and dynamics of coastal environments due to its interaction with tidal changes. However, most seagrass habitats around the globe have been in steady decline due to human impacts, disturbing the already delicate balance in the environmental conditions that sustain seagrass. Miniaturization of multi-spectral sensors has facilitated very high resolution mapping of seagrass meadows, which significantly improves the potential for ecologists to monitor changes. In this study, two analytical approaches used for classifying intertidal seagrass habitats are compared—Object-based Image Analysis (OBIA) and Fully Convolutional Neural Networks (FCNNs). Both methods produce pixel-wise classifications in order to create segmented maps. FCNNs are an emerging set of algorithms within Deep Learning. Conversely, OBIA has been a prominent solution within this field, with many studies leveraging in-situ data and multiresolution segmentation to create habitat maps. This work demonstrates the utility of FCNNs in a semi-supervised setting to map seagrass and other coastal features from an optical drone survey conducted at Budle Bay, Northumberland, England. Semi-supervision is also an emerging field within Deep Learning that has practical benefits of achieving state of the art results using only subsets of labelled data. This is especially beneficial for remote sensing applications where in-situ data is an expensive commodity. For our results, we show that FCNNs have comparable performance with the standard OBIA method used by ecologists. [ABSTRACT FROM AUTHOR]

Geometric feature extraction of 3D point clouds plays an important role in many 3D computer vision applications such as region labeling, 3D reconstruction, object segmentation, and recognition. However, hand-designed features on point clouds lack semantic information, so cannot meet these requirements. In this paper, we propose local feature extraction network (LFE-Net) which focus on extracting local feature for point clouds analysis. Such geometric features learning from a relation of local points can be used in a variety of shape analysis problems such as classification, part segmentation, and point matching. LFE-Net consists of local geometric relation (LGR) module which aims to learn a high-dimensional local feature to express the relation between points and their neighbors. Benefiting from the additional singular values of local points and hierarchical neural networks, the learned local features are robust to permutation and rigid transformation so that they can be transformed into 3D descriptors. Moreover, we embed prior spatial information of the local points into the sub-features for combining features from multiple levels. LFE-Net achieves state-of-the-art performances on standard benchmarks including ModelNet40, ShapeNetPart. [ABSTRACT FROM AUTHOR]

Automatic extractive text summarization retrieves a subset of data that represents most notable sentences in the entire document. In the era of digital explosion, which is mostly unstructured textual data, there is a demand for users to understand the huge amount of text in a short time; this demands the need for an automatic text summarizer. From summaries, the users get the idea of the entire content of the document and can decide whether to read the entire document or not. This work mainly focuses on generating a summary from multiple news documents. In this case, the summary helps to reduce the redundant news from the different newspapers. A multi-document summary is more challenging than a single-document summary since it has to solve the problem of overlapping information among sentences from different documents. Extractive text summarization yields the sensitive part of the document by neglecting the irrelevant and redundant sentences. In this paper, we propose a framework for extracting a summary from multiple documents in the Malayalam Language. Also, since the multi-document summarization data set is sparse, methods based on deep learning are difficult to apply. The proposed work discusses the performance of existing standard algorithms in multi-document summarization of the Malayalam Language. We propose a sentence extraction algorithm that selects the top ranked sentences with maximum diversity. The system is found to perform well in terms of precision, recall, and F-measure on multiple input documents. [ABSTRACT FROM AUTHOR]

Image retrieval applying deep convolutional features has achieved the most advanced performance in most standard benchmark tests. In image retrieval, deep metric learning (DML) plays a key role and aims to capture semantic similarity information carried by data points. However, two factors may impede the accuracy of image retrieval. First, when learning the similarity of negative examples, current methods separate negative pairs into equal distance in the embedding space. Thus, the intraclass data distribution might be missed. Second, given a query, either a fraction of data points, or all of them, are incorporated to build up the similarity structure, which makes it rather complex to calculate similarity or to choose example pairs. In this study, in order to achieve more accurate image retrieval, we proposed a method based on learning to rank and multiple loss (LRML). To address the first problem, through learning the ranking sequence, we separate the negative pairs from the query image into different distance. To tackle the second problem, we used a positive example in the gallery and negative sets from the bottom five ranked by similarity, thereby enhancing training efficiency. Our significant experimental results demonstrate that the proposed method achieves state-of-the-art performance on three widely used benchmarks. [ABSTRACT FROM AUTHOR]

Knowing when a machine learning system is not confident about its prediction is crucial in medical domains where safety is critical. Ideally, a machine learning algorithm should make a prediction only when it is highly certain about its competency, and refer the case to physicians otherwise. In this paper, we investigate how Bayesian deep learning can improve the performance of the machine–physician team in the skin lesion classification task. We used the publicly available HAM10000 dataset, which includes samples from seven common skin lesion categories: Melanoma (MEL), Melanocytic Nevi (NV), Basal Cell Carcinoma (BCC), Actinic Keratoses and Intraepithelial Carcinoma (AKIEC), Benign Keratosis (BKL), Dermatofibroma (DF), and Vascular (VASC) lesions. Our experimental results show that Bayesian deep networks can boost the diagnostic performance of the standard DenseNet-169 model from 81.35% to 83.59% without incurring additional parameters or heavy computation. More importantly, a hybrid physician–machine workflow reaches a classification accuracy of 90 % while only referring 35 % of the cases to physicians. The findings are expected to generalize to other medical diagnosis applications. We believe that the availability of risk-aware machine learning methods will enable a wider adoption of machine learning technology in clinical settings. [ABSTRACT FROM AUTHOR]