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Vegetation in the terrestrial ecosystem, sensitive to climate change and human activities, exerts a crucial influence on the carbon cycles in land, ocean, and atmosphere. Discrimination between climate and human-induced vegetation dynamics is advocated but still limited, especially in coastal China, which is characterized by a developed economy, a large population, and high food production, but also by unprecedented climate change and warming. Taking coastal China as the research area, our study used the normalized difference vegetation index (NDVI) in growing seasons, as well as precipitation, temperature, and sunlight hours datasets, adopted residual trend analysis at pixel and regional scales in coastal China from 2000–2019 and aims to (1) delineate the patterns and processes of vegetation changes, and (2) separate the relative contributions of climate and human activities by adopting residual trend analysis. The results indicated that (1) coastal China experienced the most vegetation greening (83.04% of the whole region) and partial degradation (16.86% of the whole region) with significant spatial heterogeneity; (2) compared with climate change, human activities have a greater positive impact on NDVI, and the regions were mainly located in the north of the North China Plain and the south of southern China; (3) the relative contribution rates of climate change and human activities were detected to be 0–60% and 60–100%, respectively; (4) in the northern coastal areas, the improvement of cultivated land management greatly promoted the greening of vegetation and thus the increase of grain yield, while in southern coastal areas, afforestation and the restoration of degraded forest were responsible for vegetation restoration; and (5) similar results obtained by partial correlation between nighttime lights and NDVI indicated the reliability of the residual trend analysis. The linear relationships of precipitation, temperature, and radiation on NDVI may limit the accurate estimation of climate drivers on vegetation, and further ecosystem process-modeling approaches can be used to estimate the relative contribution of climate change and human activities. The findings in our research emphasized that the attribution for vegetation dynamics with heterogeneity can provide evidence for the designation of rational ecological conservation policies. [ABSTRACT FROM AUTHOR]