1. Antibacterial, Antifungal and Cytotoxic Isoquinoline Alkaloids from Litsea cubeba.
- Author
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Wei Zhang, Jin-Feng Hu, Wen-Wen Lv, Qing-Chun Zhao, and Guo-Bing Shi
- Subjects
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ANTIBACTERIAL agents , *ANTIFUNGAL agents , *ANTINEOPLASTIC agents , *ISOQUINOLINE alkaloids , *STAPHYLOCOCCUS aureus , *CELL lines - Abstract
Five novel isoquinoline alkaloids (+)-N-(methoxylcarbonyl)-N-nordicentrin (1), (+)-N-(methoxylcarbonyl)-N-norpredicentrine (2), (+)-N-(methoxylcarbonyl)-N-norbulbodione (3), and (+)-N-(methoxylcarbonyl)-N-norisocorydione (4), and (+)-8-methoxyisolaurenine-Noxide (5) were isolated, together with one known compound, (+)-N-(methoxylcarbonyl)- N-norglaucine (6), from a 70% EtOH extract of the barks of Litsea cubeba. Structural elucidation of all the compounds were performed by spectral methods such as 1D- and 2D-NMR, IR, UV, and HRESIMS. Alkaloids 1, 2 and 6 showed antimicrobial activity against the bacterium S. aureus and two fungi (A. alternata and C. nicotianae). Compounds 3,4 exhibited significant cytotoxicity against all of six tested tumor cell lines. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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