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The diagnosis of brain tumors at an early stage is an exigent task for radiologists. Untreated patients rarely survive more than six months. It is a potential cause of mortality that can occur very quickly. Because of this, the early and effective diagnosis of brain tumors requires the use of an automated method. This study aims at the early detection of brain tumors using brain magnetic resonance imaging (MRI) data and efficient learning paradigms. In visual feature extraction, convolutional neural networks (CNN) have achieved significant breakthroughs. The study involves features extraction by deep convolutional layers for the efficient classification of brain tumor victims from the normal group. The deep convolutional neural network was implemented to extract features that represent the image more comprehensively for model training. Using deep convolutional features helps to increase the precision of tumor and non-tumor patient classifications. In this paper, we experimented with five machine learnings (ML) to heighten the understanding and enhance the scope and significance of brain tumor classification. Further, we proposed an ensemble of three high-performing individual ML models, namely Extreme Gradient Boosting, Ada-Boost, and Random Forest (XG-Ada-RF), to derive binary class classification output for detecting brain tumors in images. The proposed voting classifier, along with convoluted features, produced results that showed the highest accuracy of 95.9% for tumor and 94.9% for normal. Compared to individual methods, the proposed ensemble approach demonstrated improved accuracy and outperformed the individual methods. [ABSTRACT FROM AUTHOR]

Breast cancer is one of the most prevalent cancers among women worldwide, and early detection of the disease can be lifesaving. Detecting breast cancer early allows for treatment to begin faster, increasing the chances of a successful outcome. Machine learning helps in the early detection of breast cancer even in places where there is no access to a specialist doctor. The rapid advancement of machine learning, and particularly deep learning, leads to an increase in the medical imaging community's interest in applying these techniques to improve the accuracy of cancer screening. Most of the data related to diseases is scarce. On the other hand, deep-learning models need much data to learn well. For this reason, the existing deep-learning models on medical images cannot work as well as other images. To overcome this limitation and improve breast cancer classification detection, inspired by two state-of-the-art deep networks, GoogLeNet and residual block, and developing several new features, this paper proposes a new deep model to classify breast cancer. Utilizing adopted granular computing, shortcut connection, two learnable activation functions instead of traditional activation functions, and an attention mechanism is expected to improve the accuracy of diagnosis and consequently decrease the load on doctors. Granular computing can improve diagnosis accuracy by capturing more detailed and fine-grained information about cancer images. The proposed model's superiority is demonstrated by comparing it to several state-of-the-art deep models and existing works using two case studies. The proposed model achieved an accuracy of 93% and 95% on ultrasound images and breast histopathology images, respectively. [ABSTRACT FROM AUTHOR]

Glioblastoma (GBM) is a common and deadly brain tumor with late diagnoses and poor prognoses. Machine learning (ML) is an emerging tool that can create highly accurate diagnostic and prognostic prediction models. This paper aimed to systematically search the literature on ML for GBM metabolism and assess recent advancements. A literature search was performed using predetermined search terms. Articles describing the use of an ML algorithm for GBM metabolism were included. Ten studies met the inclusion criteria for analysis: diagnostic (n = 3, 30%), prognostic (n = 6, 60%), or both (n = 1, 10%). Most studies analyzed data from multiple databases, while 50% (n = 5) included additional original samples. At least 2536 data samples were run through an ML algorithm. Twenty-seven ML algorithms were recorded with a mean of 2.8 algorithms per study. Algorithms were supervised (n = 24, 89%), unsupervised (n = 3, 11%), continuous (n = 19, 70%), or categorical (n = 8, 30%). The mean reported accuracy and AUC of ROC were 95.63% and 0.779, respectively. One hundred six metabolic markers were identified, but only EMP3 was reported in multiple studies. Many studies have identified potential biomarkers for GBM diagnosis and prognostication. These algorithms show promise; however, a consensus on even a handful of biomarkers has not yet been made. [ABSTRACT FROM AUTHOR]

The paper presents a comparison of automatic skin cancer diagnosis algorithms based on analyses of skin lesions photos. Two approaches are presented: the first one is based on the extraction of features from images using simple feature descriptors, and then the use of selected machine learning algorithms for the purpose of classification, and the second approach uses selected algorithms belonging to the subgroup of machine learning—deep learning, i.e., convolutional neural networks (CNN), which perform both the feature extraction and classification in one algorithm. The following algorithms were analyzed and compared: Logistic Regression, k-Nearest Neighbors, Naive Bayes, Decision Tree, Random Forest, and Support Vector Machine, and four CNN–VGG-16, ResNet60, InceptionV3, and Inception-ResNetV2 In the first variant, before the classification process, the image features were extracted using 4 different feature descriptors and combined in various combinations in order to obtain the most accurate image features vector, and thus the highest classification accuracy. The presented approaches have been validated using the image dataset from the ISIC database, which includes data from two categories—benign and malignant skin lesions. Common machine learning metrics and saved values of training time were used to evaluate the effectiveness and the performance (computational complexity) of the algorithms. [ABSTRACT FROM AUTHOR]

Brain tumors (BTs) are deadly diseases that can strike people of every age, all over the world. Every year, thousands of people die of brain tumors. Brain-related diagnoses require caution, and even the smallest error in diagnosis can have negative repercussions. Medical errors in brain tumor diagnosis are common and frequently result in higher patient mortality rates. Magnetic resonance imaging (MRI) is widely used for tumor evaluation and detection. However, MRI generates large amounts of data, making manual segmentation difficult and laborious work, limiting the use of accurate measurements in clinical practice. As a result, automated and dependable segmentation methods are required. Automatic segmentation and early detection of brain tumors are difficult tasks in computer vision due to their high spatial and structural variability. Therefore, early diagnosis or detection and treatment are critical. Various traditional Machine learning (ML) techniques have been used to detect various types of brain tumors. The main issue with these models is that the features were manually extracted. To address the aforementioned insightful issues, this paper presents a hybrid deep transfer learning (GN-AlexNet) model of BT tri-classification (pituitary, meningioma, and glioma). The proposed model combines GoogleNet architecture with the AlexNet model by removing the five layers of GoogleNet and adding ten layers of the AlexNet model, which extracts features and classifies them automatically. On the same CE-MRI dataset, the proposed model was compared to transfer learning techniques (VGG-16, AlexNet, SqeezNet, ResNet, and MobileNet-V2) and ML/DL. The proposed model outperformed the current methods in terms of accuracy and sensitivity (accuracy of 99.51% and sensitivity of 98.90%). [ABSTRACT FROM AUTHOR]

Simple Summary: This study aimed to develop a deep learning model based on a convolutional neural network (CNN) architecture to predict Invasive Ductal Carcinoma (IDC), a form of breast cancer. The model also includes a user-friendly graphical interface for healthcare professionals to utilize the tool conveniently. The results of the study showed a high accuracy rate, suggesting the potential of this model in improving early breast cancer detection and personalized treatment strategies. Background: Deep learning models have shown potential in improving cancer diagnosis and treatment. This study aimed to develop a convolutional neural network (CNN) model to predict Invasive Ductal Carcinoma (IDC), a common type of breast cancer. Additionally, a user-friendly interface was designed to facilitate the use of the model by healthcare professionals. Methods: The CNN model was trained and tested using a dataset of high-resolution microscopic images derived from 162 whole-mount slide images of breast cancer specimens. These images were meticulously scanned at 40× magnification using a state-of-the-art digital slide scanner to capture detailed information. Each image was then divided into 277,524 patches of 50 × 50 pixels, resulting in a diverse dataset containing 198,738 IDC-negative and 78,786 IDC-positive patches. Results: The model achieved an accuracy of 98.24% in distinguishing between benign and malignant cases, demonstrating its effectiveness in cancer detection. Conclusions: This study suggests that the developed CNN model has promising potential for clinical applications in breast cancer diagnosis and personalized treatment strategies. Our study further emphasizes the importance of accurate and reliable cancer detection methods for timely diagnosis and treatment. This study establishes a foundation for utilizing deep learning models in future cancer treatment research by demonstrating their effectiveness in analyzing large and complex datasets. This approach opens exciting avenues for further research and potentially improves our understanding of cancer and its treatment. [ABSTRACT FROM AUTHOR]

Many patients affected by breast cancer die every year because of improper diagnosis and treatment. In recent years, applications of deep learning algorithms in the field of breast cancer detection have proved to be quite efficient. However, the application of such techniques has a lot of scope for improvement. Major works have been done in this field, however it can be made more efficient by the use of transfer learning to get impressive results. In the proposed approach, Convolutional Neural Network (CNN) is complemented with Transfer Learning for increasing the efficiency and accuracy of early detection of breast cancer for better diagnosis. The thought process involved using a pre-trained model, which already had some weights assigned rather than building the complete model from scratch. This paper mainly focuses on ResNet101 based Transfer Learning Model paired with the ImageNet dataset. The proposed framework provided us with an accuracy of 99.58%. Extensive experiments and tuning of hyperparameters have been performed to acquire the best possible results in terms of classification. The proposed frameworks aims to be an efficient tool for all doctors and society as a whole and help the user in early detection of breast cancer. [ABSTRACT FROM AUTHOR]

Background: In response to the escalating global concerns surrounding skin cancer, this study aims to address the imperative for precise and efficient diagnostic methodologies. Focusing on the intricate task of eight-class skin cancer classification, the research delves into the limitations of conventional diagnostic approaches, often hindered by subjectivity and resource constraints. The transformative potential of Artificial Intelligence (AI) in revolutionizing diagnostic paradigms is underscored, emphasizing significant improvements in accuracy and accessibility. Methods: Utilizing cutting-edge deep learning models on the ISIC2019 dataset, a comprehensive analysis is conducted, employing a diverse array of pre-trained ImageNet architectures and Vision Transformer models. To counteract the inherent class imbalance in skin cancer datasets, a pioneering "Naturalize" augmentation technique is introduced. This technique leads to the creation of two indispensable datasets—the Naturalized 2.4K ISIC2019 and groundbreaking Naturalized 7.2K ISIC2019 datasets—catalyzing advancements in classification accuracy. The "Naturalize" augmentation technique involves the segmentation of skin cancer images using the Segment Anything Model (SAM) and the systematic addition of segmented cancer images to a background image to generate new composite images. Results: The research showcases the pivotal role of AI in mitigating the risks of misdiagnosis and under-diagnosis in skin cancer. The proficiency of AI in analyzing vast datasets and discerning subtle patterns significantly augments the diagnostic prowess of dermatologists. Quantitative measures such as confusion matrices, classification reports, and visual analyses using Score-CAM across diverse dataset variations are meticulously evaluated. The culmination of these endeavors resulted in an unprecedented achievement—100% average accuracy, precision, recall, and F1-score—within the groundbreaking Naturalized 7.2K ISIC2019 dataset. Conclusion: This groundbreaking exploration highlights the transformative capabilities of AI-driven methodologies in reshaping the landscape of skin cancer diagnosis and patient care. The research represents a pivotal stride towards redefining dermatological diagnosis, showcasing the remarkable impact of AI-powered solutions in surmounting the challenges inherent in skin cancer diagnosis. The attainment of 100% across crucial metrics within the Naturalized 7.2K ISIC2019 dataset serves as a testament to the transformative capabilities of AI-driven approaches in reshaping the trajectory of skin cancer diagnosis and patient care. This pioneering work paves the way for a new era in dermatological diagnostics, heralding the dawn of unprecedented precision and efficacy in the identification and classification of skin cancers. [ABSTRACT FROM AUTHOR]

Brain tumor diagnosis traditionally relies on the manual examination of magnetic resonance images (MRIs), a process that is prone to human error and is also time consuming. Recent advancements leverage machine learning models to categorize tumors, such as distinguishing between "malignant" and "benign" classes. This study focuses on the supervised machine learning task of classifying "firm" and "soft" meningiomas, critical for determining optimal brain tumor treatment. The research aims to enhance meningioma firmness detection using state-of-the-art deep learning architectures. The study employs a YOLO architecture adapted for meningioma classification (Firm vs. Soft). This YOLO-based model serves as a machine learning component within a proposed CAD system. To improve model generalization and combat overfitting, transfer learning and data augmentation techniques are explored. Intra-model analysis is conducted for each of the five YOLO versions, optimizing parameters such as the optimizer, batch size, and learning rate based on sensitivity and training time. YOLOv3, YOLOv4, and YOLOv7 demonstrate exceptional sensitivity, reaching 100%. Comparative analysis against state-of-the-art models highlights their superiority. YOLOv7, utilizing the SGD optimizer, a batch size of 64, and a learning rate of 0.01, achieves outstanding overall performance with metrics including mean average precision (99.96%), precision (98.50%), specificity (97.95%), balanced accuracy (98.97%), and F1-score (99.24%). This research showcases the effectiveness of YOLO architectures in meningioma firmness detection, with YOLOv7 emerging as the optimal model. The study's findings underscore the significance of model selection and parameter optimization for achieving high sensitivity and robust overall performance in brain tumor classification. [ABSTRACT FROM AUTHOR]

Breast cancer is the second most common cancer in women who are mainly middle-aged and older. The American Cancer Society reported that the average risk of developing breast cancer sometime in their life is about 13%, and this incident rate has increased by 0.5% per year in recent years. A biopsy is done when screening tests and imaging results show suspicious breast changes. Advancements in computer-aided system capabilities and performance have fueled research using histopathology images in cancer diagnosis. Advances in machine learning and deep neural networks have tremendously increased the number of studies developing computerized detection and classification models. The dataset-dependent nature and trial-and-error approach of the deep networks' performance produced varying results in the literature. This work comprehensively reviews the studies published between 2010 and 2022 regarding commonly used public-domain datasets and methodologies used in preprocessing, segmentation, feature engineering, machine-learning approaches, classifiers, and performance metrics. [ABSTRACT FROM AUTHOR]

Artificial intelligence (AI) has significantly impacted thyroid cancer diagnosis in recent years, offering advanced tools and methodologies that promise to revolutionize patient outcomes. This review provides an exhaustive overview of the contemporary frameworks employed in the field, focusing on the objective of AI-driven analysis and dissecting methodologies across supervised, unsupervised, and ensemble learning. Specifically, we delve into techniques such as deep learning, artificial neural networks, traditional classification, and probabilistic models (PMs) under supervised learning. With its prowess in clustering and dimensionality reduction, unsupervised learning (USL) is explored alongside ensemble methods, including bagging and potent boosting algorithms. The thyroid cancer datasets (TCDs) are integral to our discussion, shedding light on vital features and elucidating feature selection and extraction techniques critical for AI-driven diagnostic systems. We lay out the standard assessment criteria across classification, regression, statistical, computer vision, and ranking metrics, punctuating the discourse with a real-world example of thyroid cancer detection using AI. Additionally, this study culminates in a critical analysis, elucidating current limitations and delineating the path forward by highlighting open challenges and prospective research avenues. Through this comprehensive exploration, we aim to offer readers a panoramic view of AI's transformative role in thyroid cancer diagnosis, underscoring its potential and pointing toward an optimistic future. [ABSTRACT FROM AUTHOR]

Breast cancer is the leading type of cancer in women, causing nearly 600,000 deaths every year, globally. Although the tumors can be localized within the breast, they can spread to other body parts, causing more harm. Therefore, early diagnosis can help reduce the risks of this cancer. However, a breast cancer diagnosis is complicated, requiring biopsy by various methods, such as MRI, ultrasound, BI-RADS, or even needle aspiration and cytology with the suggestions of specialists. On certain occasions, such as body examinations of a large number of people, it is also a large workload to check the images. Therefore, in this work, we present an efficient and automatic diagnosis system based on the hierarchical extreme learning machine (H-ELM) for breast cancer ultrasound results with high efficiency and make a primary diagnosis of the images. To make it compatible to use, this system consists of PNG images and general medical software within the H-ELM framework, which is easily trained and applied. Furthermore, this system only requires ultrasound images on a small scale, of 28 × 28 pixels, reducing the resources and fulfilling the application with low-resolution images. The experimental results show that the system can achieve 86.13% in the classification of breast cancer based on ultrasound images from the public breast ultrasound images (BUSI) dataset, without other relative information and supervision, which is higher than the conventional deep learning methods on the same dataset. Moreover, the training time is highly reduced, to only 5.31 s, and consumes few resources. The experimental results indicate that this system could be helpful for precise and efficient early diagnosis of breast cancers with primary examination results. [ABSTRACT FROM AUTHOR]

Uncontrolled and fast cell proliferation is the cause of brain tumors. Early cancer detection is vitally important to save many lives. Brain tumors can be divided into several categories depending on the kind, place of origin, pace of development, and stage of progression; as a result, tumor classification is crucial for targeted therapy. Brain tumor segmentation aims to delineate accurately the areas of brain tumors. A specialist with a thorough understanding of brain illnesses is needed to manually identify the proper type of brain tumor. Additionally, processing many images takes time and is tiresome. Therefore, automatic segmentation and classification techniques are required to speed up and enhance the diagnosis of brain tumors. Tumors can be quickly and safely detected by brain scans using imaging modalities, including computed tomography (CT), magnetic resonance imaging (MRI), and others. Machine learning (ML) and artificial intelligence (AI) have shown promise in developing algorithms that aid in automatic classification and segmentation utilizing various imaging modalities. The right segmentation method must be used to precisely classify patients with brain tumors to enhance diagnosis and treatment. This review describes multiple types of brain tumors, publicly accessible datasets, enhancement methods, segmentation, feature extraction, classification, machine learning techniques, deep learning, and learning through a transfer to study brain tumors. In this study, we attempted to synthesize brain cancer imaging modalities with automatically computer-assisted methodologies for brain cancer characterization in ML and DL frameworks. Finding the current problems with the engineering methodologies currently in use and predicting a future paradigm are other goals of this article. [ABSTRACT FROM AUTHOR]

Cancer is a dangerous and sometimes life-threatening disease that can have several negative consequences for the body, is a leading cause of mortality, and is becoming increasingly difficult to detect. Each form of cancer has its own set of traits, symptoms, and therapies, and early identification and management are important for a positive prognosis. Doctors utilize a variety of approaches to detect cancer, depending on the kind and location of the tumor. Imaging tests such as X-rays, Computed Tomography scans, Magnetic Resonance Imaging scans, and Positron Emission Tomography (PET) scans, which may provide precise pictures of the body's interior structures to spot any abnormalities, are some of the tools that doctors use to diagnose cancer. This article evaluates computational-intelligence approaches and provides a means to impact future work by focusing on the relevance of machine learning and deep learning models such as K Nearest Neighbour (KNN), Support Vector Machine (SVM), Naïve Bayes, Decision Tree, Deep Neural Network, Deep Boltzmann machine, and so on. It evaluates information from 114 studies using Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). This article explores the advantages and disadvantages of each model and provides an outline of how they are used in cancer diagnosis. In conclusion, artificial intelligence shows significant potential to enhance cancer imaging and diagnosis, despite the fact that there are a number of clinical issues that need to be addressed. [ABSTRACT FROM AUTHOR]

Cancer is a problematic global health issue with an extremely high fatality rate throughout the world. The application of various machine learning techniques that have appeared in the field of cancer diagnosis in recent years has provided meaningful insights into efficient and precise treatment decision-making. Due to rapid advancements in sequencing technologies, the detection of cancer based on gene expression data has improved over the years. Different types of cancer affect different parts of the body in different ways. Cancer that affects the mouth, lip, and upper throat is known as oral cancer, which is the sixth most prevalent form of cancer worldwide. India, Bangladesh, China, the United States, and Pakistan are the top five countries with the highest rates of oral cavity disease and lip cancer. The major causes of oral cancer are excessive use of tobacco and cigarette smoking. Many people's lives can be saved if oral cancer (OC) can be detected early. Early identification and diagnosis could assist doctors in providing better patient care and effective treatment. OC screening may advance with the implementation of artificial intelligence (AI) techniques. AI can provide assistance to the oncology sector by accurately analyzing a large dataset from several imaging modalities. This review deals with the implementation of AI during the early stages of cancer for the proper detection and treatment of OC. Furthermore, performance evaluations of several DL and ML models have been carried out to show that the DL model can overcome the difficult challenges associated with early cancerous lesions in the mouth. For this review, we have followed the rules recommended for the extension of scoping reviews and meta-analyses (PRISMA-ScR). Examining the reference lists for the chosen articles helped us gather more details on the subject. Additionally, we discussed AI's drawbacks and its potential use in research on oral cancer. There are methods for reducing risk factors, such as reducing the use of tobacco and alcohol, as well as immunization against HPV infection to avoid oral cancer, or to lessen the burden of the disease. Additionally, officious methods for preventing oral diseases include training programs for doctors and patients as well as facilitating early diagnosis via screening high-risk populations for the disease. [ABSTRACT FROM AUTHOR]

Early detection and diagnosis of oral cancer are critical for a better prognosis, but accurate and automatic identification is difficult using the available technologies. Optical coherence tomography (OCT) can be used as diagnostic aid due to the advantages of high resolution and non-invasion. We aim to evaluate deep-learning-based algorithms for OCT images to assist clinicians in oral cancer screening and diagnosis. An OCT data set was first established, including normal mucosa, precancerous lesion, and oral squamous cell carcinoma. Then, three kinds of convolutional neural networks (CNNs) were trained and evaluated by using four metrics (accuracy, precision, sensitivity, and specificity). Moreover, the CNN-based methods were compared against machine learning approaches through the same dataset. The results show the performance of CNNs, with a classification accuracy of up to 96.76%, is better than the machine-learning-based method with an accuracy of 92.52%. Moreover, visualization of lesions in OCT images was performed and the rationality and interpretability of the model for distinguishing different oral tissues were evaluated. It is proved that the automatic identification algorithm of OCT images based on deep learning has the potential to provide decision support for the effective screening and diagnosis of oral cancer. [ABSTRACT FROM AUTHOR]

One of the most prevalent cancers in women is breast cancer. The mortality rate related to this disease can be decreased by early, accurate diagnosis to increase the chance of survival. Infrared thermal imaging is one of the breast imaging modalities in which the temperature of the breast tissue is measured using a screening tool. The previous studies did not use pre-trained deep learning (DL) with deep attention mechanisms (AMs) on thermographic images for breast cancer diagnosis. Using thermal images from the Database for Research Mastology with Infrared Image (DMR-IR), the study investigates the use of a pre-trained Visual Geometry Group with 16 layers (VGG16) with AMs that can produce good diagnosis performance utilizing the thermal images of breast cancer. The symmetry of the three models resulting from the combination of VGG16 with three types of AMs is evident in all its stages in methodology. The models were compared to state-of-art breast cancer diagnosis approaches and tested for accuracy, sensitivity, specificity, precision, F1-score, AUC score, and Cohen's kappa. The test accuracy rates for the AMs using the VGG16 model on the breast thermal dataset were encouraging, at 99.80%, 99.49%, and 99.32%. Test accuracy for VGG16 without AMs was 99.18%, whereas test accuracy for VGG16 with AMs improved by 0.62%. The proposed approaches also performed better than previous approaches examined in the related studies. [ABSTRACT FROM AUTHOR]

After cardiovascular diseases, cancer is responsible for the most deaths worldwide. Detecting a cancer disease early improves the chances for healing significantly. One group of technologies that is increasingly applied for detecting cancer is artificial intelligence. Artificial intelligence has great potential to support clinicians and medical practitioners as it allows for the early detection of carcinomas. During recent years, research on artificial intelligence for cancer detection grew a lot. Within this article, we conducted a bibliometric study of the existing research dealing with the application of artificial intelligence in cancer detection. We analyzed 6450 articles on that topic that were published between 1986 and 2022. By doing so, we were able to give an overview of this research field, including its key topics, relevant outlets, institutions, and articles. Based on our findings, we developed a future research agenda that can help to advance research on artificial intelligence for cancer detection. In summary, our study is intended to serve as a platform and foundation for researchers that are interested in the potential of artificial intelligence for detecting cancer. [ABSTRACT FROM AUTHOR]

A lung nodule is a tiny growth that develops in the lung. Non-cancerous nodules do not spread to other sections of the body. Malignant nodules can spread rapidly. One of the numerous dangerous kinds of cancer is lung cancer. It is responsible for taking the lives of millions of individuals each year. It is necessary to have a highly efficient technology capable of analyzing the nodule in the pre-cancerous phases of the disease. However, it is still difficult to detect nodules in CT scan data, which is an issue that has to be overcome if the following treatment is going to be effective. CT scans have been used for several years to diagnose nodules for future therapy. The radiologist can make a mistake while determining the nodule's presence and size. There is room for error in this process. Radiologists will compare and analyze the images obtained from the CT scan to ascertain the nodule's location and current status. It is necessary to have a dependable system that can locate the nodule in the CT scan images and provide radiologists with an automated report analysis that is easy to comprehend. In this study, we created and evaluated an algorithm that can identify a nodule by comparing multiple photos. This gives the radiologist additional data to work with in diagnosing cancer in its earliest stages in the nodule. In addition to accuracy, various characteristics were assessed during the performance assessment process. The final CNN algorithm has 84.8% accuracy, 90.47% precision, and 90.64% specificity. These numbers are all relatively close to one another. As a result, one may argue that CNN is capable of minimizing the number of false positives through in-depth training that is performed frequently. [ABSTRACT FROM AUTHOR]

Healthcare systems in recent times have witnessed timely diagnoses with a high level of accuracy. Internet of Medical Things (IoMT)-enabled deep learning (DL) models have been used to support medical diagnostics in real time, thus resolving the issue of late-stage diagnosis of various diseases and increasing performance accuracy. The current approach for the diagnosis of leukemia uses traditional procedures, and in most cases, fails in the initial period. Hence, several patients suffering from cancer have died prematurely due to the late discovery of cancerous cells in blood tissue. Therefore, this study proposes an IoMT-enabled convolutional neural network (CNN) model to detect malignant and benign cancer cells in the patient's blood tissue. In particular, the hyper-parameter optimization through radial basis function and dynamic coordinate search (HORD) optimization algorithm was used to search for optimal values of CNN hyper-parameters. Utilizing the HORD algorithm significantly increased the effectiveness of finding the best solution for the CNN model by searching multidimensional hyper-parameters. This implies that the HORD method successfully found the values of hyper-parameters for precise leukemia features. Additionally, the HORD method increased the performance of the model by optimizing and searching for the best set of hyper-parameters for the CNN model. Leukemia datasets were used to evaluate the performance of the proposed model using standard performance indicators. The proposed model revealed significant classification accuracy compared to other state-of-the-art models. [ABSTRACT FROM AUTHOR]

Simple Summary: The rapid development of technology has enabled numerous applications of artificial intelligence (AI), especially in medical science. Histopathological assessment of tissues remains the gold standard for diagnosis of gastrointestinal (GI) cancers for subsequent management. In a traditional anatomical pathology (AP) laboratory, histopathologists are required to manually assess, quantify and classify diseases under a microscope in a semiquantitative or qualitative manner. The conversion of analogue-to-digital pathology is on the rise, conforming with trends toward digitalization. The rapid adoption of digital pathology (DP) is driven by factors such as the worldwide shortage of pathologists and medical technologists, the increasing incidence of cancer and the critical need to improve laboratory efficiency. In this review, we aim to provide a comprehensive summary of algorithms for AI detection and classification of GI cancer. We will also provide critical insight into the application of algorithms for routine care in clinical practice. The implementation of DP will revolutionize current practice by providing pathologists with additional tools and algorithms to improve workflow. Furthermore, DP will open up opportunities for development of AI-based tools for more precise and reproducible diagnosis through computational pathology. One of the key features of AI is its capability to generate perceptions and recognize patterns beyond the human senses. Thus, the incorporation of AI into DP can reveal additional morphological features and information. At the current rate of AI development and adoption of DP, the interest in computational pathology is expected to rise in tandem. There have already been promising developments related to AI-based solutions in prostate cancer detection; however, in the GI tract, development of more sophisticated algorithms is required to facilitate histological assessment of GI specimens for early and accurate diagnosis. In this review, we aim to provide an overview of the current histological practices in AP laboratories with respect to challenges faced in image preprocessing, present the existing AI-based algorithms, discuss their limitations and present clinical insight with respect to the application of AI in early detection and diagnosis of GI cancer. [ABSTRACT FROM AUTHOR]

Management of brain tumors is based on clinical and radiological information with presumed grade dictating treatment. Hence, a non-invasive assessment of tumor grade is of paramount importance to choose the best treatment plan. Convolutional Neural Networks (CNNs) represent one of the effective Deep Learning (DL)-based techniques that have been used for brain tumor diagnosis. However, they are unable to handle input modifications effectively. Capsule neural networks (CapsNets) are a novel type of machine learning (ML) architecture that was recently developed to address the drawbacks of CNNs. CapsNets are resistant to rotations and affine translations, which is beneficial when processing medical imaging datasets. Moreover, Vision Transformers (ViT)-based solutions have been very recently proposed to address the issue of long-range dependency in CNNs. This survey provides a comprehensive overview of brain tumor classification and segmentation techniques, with a focus on ML-based, CNN-based, CapsNet-based, and ViT-based techniques. The survey highlights the fundamental contributions of recent studies and the performance of state-of-the-art techniques. Moreover, we present an in-depth discussion of crucial issues and open challenges. We also identify some key limitations and promising future research directions. We envisage that this survey shall serve as a good springboard for further study. [ABSTRACT FROM AUTHOR]

In recent years, artificial intelligence (AI) has shown great promise in medicine. However, explainability issues make AI applications in clinical usages difficult. Some research has been conducted into explainable artificial intelligence (XAI) to overcome the limitation of the black-box nature of AI methods. Compared with AI techniques such as deep learning, XAI can provide both decision-making and explanations of the model. In this review, we conducted a survey of the recent trends in medical diagnosis and surgical applications using XAI. We have searched articles published between 2019 and 2021 from PubMed, IEEE Xplore, Association for Computing Machinery, and Google Scholar. We included articles which met the selection criteria in the review and then extracted and analyzed relevant information from the studies. Additionally, we provide an experimental showcase on breast cancer diagnosis, and illustrate how XAI can be applied in medical XAI applications. Finally, we summarize the XAI methods utilized in the medical XAI applications, the challenges that the researchers have met, and discuss the future research directions. The survey result indicates that medical XAI is a promising research direction, and this study aims to serve as a reference to medical experts and AI scientists when designing medical XAI applications. [ABSTRACT FROM AUTHOR]

Differentiation between the various non-small-cell lung cancer subtypes is crucial for providing an effective treatment to the patient. For this purpose, machine learning techniques have been used in recent years over the available biological data from patients. However, in most cases this problem has been treated using a single-modality approach, not exploring the potential of the multi-scale and multi-omic nature of cancer data for the classification. In this work, we study the fusion of five multi-scale and multi-omic modalities (RNA-Seq, miRNA-Seq, whole-slide imaging, copy number variation, and DNA methylation) by using a late fusion strategy and machine learning techniques. We train an independent machine learning model for each modality and we explore the interactions and gains that can be obtained by fusing their outputs in an increasing manner, by using a novel optimization approach to compute the parameters of the late fusion. The final classification model, using all modalities, obtains an F1 score of 96.81 ± 1.07 , an AUC of 0.993 ± 0.004 , and an AUPRC of 0.980 ± 0.016 , improving those results that each independent model obtains and those presented in the literature for this problem. These obtained results show that leveraging the multi-scale and multi-omic nature of cancer data can enhance the performance of single-modality clinical decision support systems in personalized medicine, consequently improving the diagnosis of the patient. [ABSTRACT FROM AUTHOR]

Deep learning (DL) is a subfield of machine learning (ML), which has recently demonstrated its potency to significantly improve the quantification and classification workflows in biomedical and clinical applications. Among the end applications profoundly benefitting from DL, cellular morphology quantification is one of the pioneers. Here, we first briefly explain fundamental concepts in DL and then we review some of the emerging DL-enabled applications in cell morphology quantification in the fields of embryology, point-of-care ovulation testing, as a predictive tool for fetal heart pregnancy, cancer diagnostics via classification of cancer histology images, autosomal polycystic kidney disease, and chronic kidney diseases. [ABSTRACT FROM AUTHOR]

Machine learning models have been successfully applied for analysis of skin images. However, due to the black box nature of such deep learning models, it is difficult to understand their underlying reasoning. This prevents a human from validating whether the model is right for the right reasons. Spurious correlations and other biases in data can cause a model to base its predictions on such artefacts rather than on the true relevant information. These learned shortcuts can in turn cause incorrect performance estimates and can result in unexpected outcomes when the model is applied in clinical practice. This study presents a method to detect and quantify this shortcut learning in trained classifiers for skin cancer diagnosis, since it is known that dermoscopy images can contain artefacts. Specifically, we train a standard VGG16-based skin cancer classifier on the public ISIC dataset, for which colour calibration charts (elliptical, coloured patches) occur only in benign images and not in malignant ones. Our methodology artificially inserts those patches and uses inpainting to automatically remove patches from images to assess the changes in predictions. We find that our standard classifier partly bases its predictions of benign images on the presence of such a coloured patch. More importantly, by artificially inserting coloured patches into malignant images, we show that shortcut learning results in a significant increase in misdiagnoses, making the classifier unreliable when used in clinical practice. With our results, we, therefore, want to increase awareness of the risks of using black box machine learning models trained on potentially biased datasets. Finally, we present a model-agnostic method to neutralise shortcut learning by removing the bias in the training dataset by exchanging coloured patches with benign skin tissue using image inpainting and re-training the classifier on this de-biased dataset. [ABSTRACT FROM AUTHOR]

Simple Summary: Cancer is a deadly disease that needs to be diagnose at early stage to increase patient survival rate. Multi-organ (such as breast, brain, lung, and skin) cancer detection, segmentation and classification manually using medical imaging is time consuming and required high expertise. In this study, we summarize existing deep learning segmentation and classification methods for multi-organ cancer diagnosis and provide future challenges with possible solutions. This review may benefit researchers to design new robust approaches that could be useful for the medical specialists as a second view. Thus far, the most common cause of death in the world is cancer. It consists of abnormally expanding areas that are threatening to human survival. Hence, the timely detection of cancer is important to expanding the survival rate of patients. In this survey, we analyze the state-of-the-art approaches for multi-organ cancer detection, segmentation, and classification. This article promptly reviews the present-day works in the breast, brain, lung, and skin cancer domain. Afterwards, we analytically compared the existing approaches to provide insight into the ongoing trends and future challenges. This review also provides an objective description of widely employed imaging techniques, imaging modality, gold standard database, and related literature on each cancer in 2016–2021. The main goal is to systematically examine the cancer diagnosis systems for multi-organs of the human body as mentioned. Our critical survey analysis reveals that greater than 70% of deep learning researchers attain promising results with CNN-based approaches for the early diagnosis of multi-organ cancer. This survey includes the extensive discussion part along with current research challenges, possible solutions, and prospects. This research will endow novice researchers with valuable information to deepen their knowledge and also provide the room to develop new robust computer-aid diagnosis systems, which assist health professionals in bridging the gap between rapid diagnosis and treatment planning for cancer patients. [ABSTRACT FROM AUTHOR]

Breast cancer is one of the main causes of death among women worldwide. Early detection of this disease helps reduce the number of premature deaths. This research aims to design a method for identifying and diagnosing breast tumors based on ultrasound images. For this purpose, six techniques have been performed to detect and segment ultrasound images. Features of images are extracted using the fractal method. Moreover, k-nearest neighbor, support vector machine, decision tree, and Naïve Bayes classification techniques are used to classify images. Then, the convolutional neural network (CNN) architecture is designed to classify breast cancer based on ultrasound images directly. The presented model obtains the accuracy of the training set to 99.8%. Regarding the test results, this diagnosis validation is associated with 88.5% sensitivity. Based on the findings of this study, it can be concluded that the proposed high-potential CNN algorithm can be used to diagnose breast cancer from ultrasound images. The second presented CNN model can identify the original location of the tumor. The results show 92% of the images in the high-performance region with an AUC above 0.6. The proposed model can identify the tumor's location and volume by morphological operations as a post-processing algorithm. These findings can also be used to monitor patients and prevent the growth of the infected area. [ABSTRACT FROM AUTHOR]