1. Astragaloside IV Suppresses Hepatic Proliferation in Regenerating Rat Liver after 70% Partial Hepatectomy via Down-Regulation of Cell Cycle Pathway and DNA Replication.
- Author
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Lee GS, Jeong HY, Yang HG, Seo YR, Jung EG, Lee YS, Nam KW, and Kim WJ
- Subjects
- Animals, Cell Proliferation drug effects, Cyclin D1 metabolism, Gene Expression Regulation drug effects, Gene Regulatory Networks drug effects, Hepatocyte Growth Factor metabolism, Liver drug effects, Liver surgery, Male, Molecular Sequence Annotation, RNA, Messenger genetics, RNA, Messenger metabolism, Rats, Sprague-Dawley, Saponins chemistry, Sequence Analysis, RNA, Transforming Growth Factor beta1 metabolism, Triterpenes chemistry, Rats, Cell Cycle drug effects, DNA Replication drug effects, Down-Regulation drug effects, Hepatectomy, Liver cytology, Liver Regeneration drug effects, Saponins pharmacology, Triterpenes pharmacology
- Abstract
Astragaloside IV (AS-IV) is one of the major bio-active ingredients of huang qi which is the dried root of Astragalus membranaceus (a traditional Chinese medicinal plant). The pharmacological effects of AS-IV, including anti-oxidative, anti-cancer, and anti-diabetic effects have been actively studied, however, the effects of AS-IV on liver regeneration have not yet been fully described. Thus, the aim of this study was to explore the effects of AS-IV on regenerating liver after 70% partial hepatectomy (PHx) in rats. Differentially expressed mRNAs, proliferative marker and growth factors were analyzed. AS-IV (10 mg/kg) was administrated orally 2 h before surgery. We found 20 core genes showed effects of AS-IV, many of which were involved with functions related to DNA replication during cell division. AS-IV down-regulates MAPK signaling, PI3/Akt signaling, and cell cycle pathway. Hepatocyte growth factor (HGF) and cyclin D1 expression were also decreased by AS-IV administration. Transforming growth factor β1 (TGFβ1, growth regulation signal) was slightly increased. In short, AS-IV down-regulated proliferative signals and genes related to DNA replication. In conclusion, AS-IV showed anti-proliferative activity in regenerating liver tissue after 70% PHx.
- Published
- 2021
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