1. Complications of Autologous Stem Cell Transplantation in Multiple Myeloma: Results from the CALM Study.
- Author
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Waszczuk-Gajda, Anna, Penack, Olaf, Sbianchi, Giulia, Koster, Linda, Blaise, Didier, Reményi, Péter, Russell, Nigel, Ljungman, Per, Trneny, Marek, Mayer, Jiri, Iacobelli, Simona, Kobbe, Guido, Scheid, Christof, Apperley, Jane, Touzeau, Cyrille, Lenhoff, Stig, Jantunen, Esa, Anagnostopoulos, Achilles, Paris, Laura, and Browne, Paul
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STEM cell transplantation , *MULTIPLE myeloma , *AUTOGRAFTS , *MONOCLONAL gammopathies , *TREATMENT effectiveness , *BACTERIAL diseases - Abstract
Background: The main goal of this post hoc analysis of the Collaboration to Collect Autologous Transplant Outcomes in Lymphoma and Myeloma (CALM) study was to evaluate the rate of short- and long-term infectious and non-infectious complications occurring after ASCT in patients with multiple myeloma (MM). Methods: The analysis included all patients with MM from the CALM study who underwent ≥1 ASCT. The primary endpoint of the analysis was to determine the rate of infectious and non-infectious complications after ASCT and to compare them in three time periods: 0–100 days, 101 days–1 year, and >1 year after the first transplant. Results: The analysis included a total of 3552 patients followed up for a median of 56.7 months (range 0.4–108.1). Complication rates decreased with the time from ASCT with 24.85 cases per 100 patient-years from day 0 to 100 days after the transplant, and <2.31 cases per 100 patient-years from the 101st day. At 100 days after ASC T, 45.7% of patients had complications, with infectious events being twice as frequent as non-infectious complications. Bacterial infections (6.5 cases per 100 patient-years, 95% CI: 6.1–7.0) and gastrointestinal complications (4.7 cases per 100 patient-years, 95% CI: 4.3–5.1) were the most common early events. The pattern of complications changed with time from ASCT. The presence of complications after ASCT was not associated with overall survival. Conclusions: Our data provide a solid basis for comparing ASCT-related complications to those caused by emerging treatments in multiple myeloma, such as CAR T-cell therapy and other immunotherapies. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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