16 results on '"Blanco, Beatriz"'
Search Results
2. Preserving the Great Mosque of Cordoba (Spain): A Preliminary Mechanical Characterization of Its Original Natural Stone
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Zapico Blanco, Beatriz, primary, Rodriguez Mariscal, José Daniel, additional, Zapata Rodriguez, Elena, additional, Romero Arroyo, José Antonio, additional, Fernandez Ancio, Fernando, additional, and Solís Muñiz, Mario, additional
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- 2023
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3. Physicochemical Characterisation of Seeds, Oil and Defatted Cake of Three Hempseed Varieties Cultivated in Spain.
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Mendoza-Pérez, Rito J., Náthia-Neves, Grazielle, Blanco, Beatriz, Vela, Antonio J., Caballero, Pedro A., and Ronda, Felicidad
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DENATURATION of proteins ,UNSATURATED fatty acids ,FLOUR ,SEED size ,CAKE ,RAW materials ,SCIENCE databases - Abstract
The increasing use of hempseed in food products highlights the need for a comprehensive database for scientific research and industrial applications. In food development, information about the techno-functional properties of raw materials plays a crucial role in determining the suitability of each product for specific applications. Thus, this study aims to characterise three hempseed varieties (Ferimon, Henola and Uso-31), comparing their physicochemical and nutritional compositions. Moreover, the study investigates the impact of hempseed varieties on the techno-functional, physical and thermal properties of the partially defatted hempseed flours (PDHFs) obtained from single screw pressing (SSP) oil extraction. The fatty acid and tocopherol profiles of the dehulled seeds and oil were also analysed. Significant variations in yield and physical properties were observed among hempseed varieties, influenced by genetics, adaptation to agro-climatic conditions and cultivation systems. Despite its lower yield (kg/ha), Uso-31 exhibited superior 1000-seed weight, dehulling yield and larger mean seed size (1.79 ± 0.02 mm). Hempseed oil was rich in unsaturated fatty acids, particularly linoleic (51.2–53.4 g/100 g oil) and α-linolenic (14.88–18.97 g/100 oil) acids, showing variations in γ- and α-tocopherols depending on the variety. The variety also influenced the least gelation concentration (LGC) and techno-functional properties such as water absorption capacity (WAC), emulsifying activity (EA) and emulsion stability (ES). SDS-PAGE and DSC measurements indicated the presence of 11S and 7S globulin proteins with denaturation temperatures above 87.8 °C. These findings confirm that the studied hempseed flours are valuable techno-functional and nutritional ingredients suitable for sustainable food formulations. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Preserving the Great Mosque of Córdoba (Spain): Characterization of Natural Stone Based on Rebound Hammer and Ultrasonic Tests †.
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Rodríguez-Mariscal, José Daniel, Zapico Blanco, Beatriz, Valverde Garrido, Natalia, García-Calabrés Ibáñez, Francisco Javier, González Pozo, Marta, and Solís Muñiz, Mario
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PRESERVATION of cultural property ,ULTRASONIC testing ,NONDESTRUCTIVE testing ,STONE - Abstract
The preservation of The Great Mosque of Córdoba (Spain) as a carrier of Andalusian collective memory requires innovative approaches to assess and maintain its structural health. This research centers on two non-destructive methods: direct ultrasound testing and rebound hammer. Laboratory tests were performed on natural stone provided by the primary material supplier for the Mosque's restoration and rehabilitation works. Non-destructive and destructive tests were carried out over 10 ashlars and 100 cubic and prismatic specimens, which were cut from the ashlars. Tests were conducted in multiple directions to investigate stone anisotropy. Destructive testing indicated isotropy, but ultrasound test results disagreed. Sensitivity analysis of specimen dimensions affected result dispersion, but not average properties. [ABSTRACT FROM AUTHOR]
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- 2023
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5. Preserving the Great Mosque of Cordoba (Spain): A Preliminary Mechanical Characterization of Its Original Natural Stone †.
- Author
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Zapico Blanco, Beatriz, Rodriguez Mariscal, José Daniel, Zapata Rodriguez, Elena, Romero Arroyo, José Antonio, Fernandez Ancio, Fernando, and Solís Muñiz, Mario
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MOSQUES ,PRESERVATION of cultural property ,MECHANICAL behavior of materials ,STONE - Abstract
The Mosque of Cordoba (Spain) is an emblem of the rich cultural heritage of Western Andalusia. This research focuses on the mechanical characterization of the natural stone used in the building. Determining its properties is crucial to understanding the structural behaviour of the entire building. An experimental campaign with various mechanical tests, such as density, compression, indirect tensile, and bending tests, was conducted on more than 100 cubic and prismatic specimens obtained from the main quarry that supplies material for the mosque's restoration. The results indicated the stone's isotropic behaviour for the studied properties. Further analysis established correlations between compressive strength (averaging 6 MPa) and other mechanical properties. This preliminary characterization provides valuable information for future in situ testing and more sophisticated lab techniques. [ABSTRACT FROM AUTHOR]
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- 2023
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6. Three-Dimensional Volume Rendering in Computed Tomography for Evaluation of the Temporomandibular Joint in Dogs.
- Author
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Novales, Manuel, Lucena, Rosario, Hernández, Eduardo M., Ginel, Pedro J., Fernández, Jesús M., and Blanco, Beatriz
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COMPUTED tomography ,MULTIDETECTOR computed tomography ,DOGS ,TEMPOROMANDIBULAR joint ,JOINTS (Anatomy) ,DOG diseases - Abstract
Simple Summary: The temporomandibular joint (TMJ) of dogs is a bilateral joint mainly used for chewing, and subsequently, an area where pathologies are frequently seen. Computed tomography (CT) represents a very important imaging modality used to diagnose TMJ diseases in dogs. A three-dimensional representation of CT images created by a volume rendering method (3DVR) could improve our understanding of the alterations in this joint. In this study, we assessed 3DVR as an ancillary method for the description and diagnosis of TMJ pathologies in dogs. Based on computed tomography (CT) images, volume rendering was used to obtain a three-dimensional representation of data (3DVR). The aims of this study included: describing the bone anatomy of the temporomandibular joint (TMJ) of dogs; comparing the TMJs of each dog by skull type and age; comparing 3DVR images with three-standard-plane CTs; assessing soft tissues adjacent to the TMJ and assessing pathological cases. Multidetector computed tomography scans of bilateral TMJs of 410 dogs were observed. From a ventral view, slight displacements in the positions of the skulls were seen, whereas from a caudal view, differences in amplitude of the articular space were observed. Dolichocephalic and mesaticephalic dogs showed more similar TMJ features than brachycephalic dogs. The shape of the TMJ bones were irregular in dogs under 1 year old. The 3DVR images related to the three-standard-plane CT improved the overall comprehension of the changes in the articular space amplitude and condylar process morphology. The fovea pterygoidea, mandibular fossa and retroarticular process were perfectly shown. A better spatial situation of adjacent soft tissues was obtained. The 3DVR represents an ancillary method to the standard-plane CT that could help in the understanding of the anatomy and diagnoses of different pathologies of the TMJ in dogs. [ABSTRACT FROM AUTHOR]
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- 2023
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7. CBP and p300 Jointly Maintain Neural Progenitor Viability but Play Unique Roles in the Differentiation of Neural Lineages.
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González-Martínez, Rocío, Márquez-Galera, Angel, Del Blanco, Beatriz, López-Atalaya, Jose P., Barco, Angel, and Herrera, Eloísa
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NERVE tissue proteins ,NEURAL stem cells ,NEURAL development ,NEURONAL differentiation ,CELL division ,CELL culture - Abstract
The paralogous lysine acetyltransferases 3 (KAT3), CBP and P300, play critical roles during neurodevelopment, but their specific roles in neural precursors maintenance and differentiation remain obscure. In fact, it is still unclear whether these proteins are individually or jointly essential in processes such as proliferation of neural precursors, differentiation to specific neural cell types, or both. Here, we use subventricular zone-derived neurospheres as a potential ex vivo developmental model to analyze the proliferation and differentiation of neural stem cells (NSCs) lacking CBP, p300, or both proteins. The results showed that CBP and p300 are not individually essential for maintenance and proliferation of NSCs, although their combined ablation seriously compromised cell division. In turn, the absence of either of the two proteins compromised the differentiation of NSC into the neuronal and astrocytic lineages. Single-nucleus RNA sequencing analysis of neural cell cultures derived from CBP or p300 mutant neurospheres revealed divergent trajectories of neural differentiation upon CBP or p300 ablation, confirming unique functions and nonredundant roles in neural development. These findings contribute to a better understanding of the shared and individual roles of KAT3 proteins in neural differentiation and the etiology of neurodevelopmental disorders caused by their deficiency. [ABSTRACT FROM AUTHOR]
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- 2022
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8. Improving the Earthquake Resilience of Primary Schools in the Border Regions of Neighbouring Countries.
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Estêvão, João M. C., Morales-Esteban, Antonio, Sá, Luis F., Ferreira, Mónica A., Tomás, Bruno, Esteves, Carlos, Barreto, Vítor, Carreira, Ana, Braga, Alfredo, Requena-Garcia-Cruz, Maria-Victoria, Romero-Sanchez, Emilio, de-Miguel-Rodriguez, Jaime, Segovia-Verjel, Maria-Luisa, Blanco, Beatriz Zapico, and Oliveira, Carlos Sousa
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This work summarises the strategy adopted in the European research project PERSISTAH. It aims to increase the resilience of the population, focusing on the existing primary schools in the Algarve (Portugal) and Huelva (Spain) regions. Software was developed to assess the seismic safety of these schools, considering different earthquake scenarios. Seismic retrofitting measures were studied and numerically tested. Some of them were also implemented in the retrofitting activities of two case study schools (one in each country). It was found that the adopted ground motion prediction equations (GMPEs) considerably affect the results obtained with the software, especially for offshore earthquake scenarios. Furthermore, the results show that the masonry buildings would be the most damaged school typologies for all the scenarios considered. Additionally, a set of guidelines was created to support the school community and the technicians related to the construction industry. The goal of these documents is to increase the seismic resilience of the population. Different activities were carried out to train schoolteachers in seismic safety based on the guidelines produced, obtaining positive feedback from them. [ABSTRACT FROM AUTHOR]
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- 2022
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9. Fast Seismic Assessment of Built Urban Areas with the Accuracy of Mechanical Methods Using a Feedforward Neural Network.
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de-Miguel-Rodríguez, Jaime, Morales-Esteban, Antonio, Requena-García-Cruz, María-Victoria, Zapico-Blanco, Beatriz, Segovia-Verjel, María-Luisa, Romero-Sánchez, Emilio, and Carvalho-Estêvão, João Manuel
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Capacity curves obtained from nonlinear static analyses are widely used to perform seismic assessments of structures as an alternative to dynamic analysis. This paper presents a novel 'en masse' method to assess the seismic vulnerability of urban areas swiftly and with the accuracy of mechanical methods. At the core of this methodology is the calculation of the capacity curves of low-rise reinforced concrete buildings using neural networks, where no modeling of the building is required. The curves are predicted with minimal error, needing only basic geometric and material parameters of the structures to be specified. As a first implementation, a typology of prismatic buildings is defined and a training set of more than 7000 structures generated. The capacity curves are calculated through push-over analysis using SAP2000. The results feature the prediction of 100-point curves in a single run of the network while maintaining a very low mean absolute error. This paper proposes a method that improves current seismic assessment tools by providing a fast and accurate calculation of the vulnerability of large sets of buildings in urban environments. [ABSTRACT FROM AUTHOR]
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- 2022
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10. Updating the Food-Based Dietary Guidelines for the Spanish Population: The Spanish Society of Community Nutrition (SENC) Proposal
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Aranceta-Bartrina, Javier, Partearroyo, Teresa, Lopez-Sobaler, Ana M., Ortega, Rosa M., Varela-Moreiras, Gregorio, Serra-Majem, Lluis, Perez-Rodrigo, Carmen, Arija, Victoria, Manuel Avila-Torres, Jose, Blay-Cortes, Guadalupe, de Diego-Blanco, Beatriz, Manuel Fernandez-Garcia, Jose, Garaulet, Marta, Garriga-Garcia, Maria, Gianzo-Citores, Maria, Gil, Angel, Martinez, Venancio, Martinez de Victoria, Emilio, Nissensohn, Mariela, Ortiz-Andreluchi, Adriana, Quiles-Izquierdo, Joan, Ribas-Barba, Lourdes, Rodriguez-Martin, Amelia, Ruiz-Moreno, Emma, Ruperto-Lopez, Mar, Salvador-Castell, Gemma, Santiago-Neri, Susana, Tur, Josep A., Valero-Gaspar, Teresa, Vidal-Ibanez, Merce, and Collaborative Grp Dietary Guidelin
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0301 basic medicine ,Mediterranean diet ,humanos ,Primary health care ,cardiovascular-disease ,physical activity ,ejercicio físico ,systematic analysis ,Nutrition Policy ,0302 clinical medicine ,030212 general & internal medicine ,risk-factors ,Intersectoral Collaboration ,community health ,Nutrition and Dietetics ,dieta ,health ,sustainability ,Dietary guidelines ,Sustainability ,Health ,Community health ,Public Health ,Diet, Healthy ,lcsh:Nutrition. Foods and food supply ,medicine.medical_specialty ,Food habits ,whole-grain intake ,scientific statement ,Dietética y nutrición ,lcsh:TX341-641 ,Context (language use) ,Health Promotion ,Ciencias de la Salud::Nutrición y dietética [Materias Investigacion] ,food habits ,primary healthcare ,03 medical and health sciences ,salud pública ,sustainable diets ,Political science ,medicine ,Humans ,Product (category theory) ,Exercise ,dietary guidelines ,cognitive impairment ,Medical education ,030109 nutrition & dietetics ,Primary Health Care ,Physical activity ,Public health ,global burden ,mediterranean diet ,heart-disease ,Diet ,Spanish population ,Spain ,política nutricional ,Commentary ,Societies ,Primary healthcare ,Food Science - Abstract
This article belongs to the Special Issue Selected Papers from NUTRIMAD 2018. Diet-related risk factors and physical inactivity are among the leading risk factors for disability and are responsible for a large proportion of the burden of chronic non-communicable diseases. Food-based dietary guidelines (FBDGs) are useful tools for nutrition policies and public health strategies to promote healthier eating and physical activity. In this paper, we discuss the process followed in developing the dietary guidelines for the Spanish population by the Spanish Society of Community Nutrition (SENC) and further explain the collaboration with primary healthcare practitioners as presented in the context of the NUTRIMAD 2018 international congress of SENC. From a health in all policies approach, SENC convened a group of experts in nutrition and public health to review the evidence on diet-health, nutrient intake and food consumption in the Spanish population, as well as food preparation, determinants and impact of diet on environmental sustainability. The collaborative group drafted the document and designed the graphic icon, which was then subject to a consultation process, discussion, and qualitative evaluation. Next, a collaborative group was established to plan a dissemination strategy, involving delegates from all the primary healthcare scientific societies in Spain. A product of this collaboration was the release of an attractive, easy-to-understand publication.
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- 2019
11. New Applications of Photodynamic Therapy in the Management of Candidiasis.
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Rodríguez-Cerdeira, Carmen, Martínez-Herrera, Erick, Fabbrocini, Gabriella, Sanchez-Blanco, Beatriz, López-Barcenas, Adriana, EL-Samahy, May, Juárez-Durán, Eder R., and González-Cespón, José Luís
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PHOTODYNAMIC therapy ,WAVELENGTHS ,ANTIFUNGAL agents ,GENES ,REACTIVE oxygen species - Abstract
The most important aetiological agent of opportunistic mycoses worldwide is Candida spp. These yeasts can cause severe infections in the host, which may be fatal. Isolates of Candida albicans occur with greater frequency and variable resistance patterns. Photodynamic therapy (PDT) has been recognised as an alternative treatment to kill pathogenic microorganisms. PDT utilises a photosensitizer, which is activated at a specific wavelength and oxygen concentration. Their reaction yields reactive oxygen species that kill the infectious microorganism. A systematic review of new applications of PDT in the management of candidiasis was performed. Of the 222 studies selected for in-depth screening, 84 were included in this study. All the studies reported the antifungal effectiveness, toxicity and dosimetry of treatment with antimicrobial PDT (aPDT) with different photosensitizers against Candida spp. The manuscripts that are discussed reveal the breadth of the new applications of aPDT against Candida spp., which are resistant to common antifungals. aPDT has superior performance compared to conventional antifungal therapies. With further studies, aPDT should prove valuable in daily clinical practice. [ABSTRACT FROM AUTHOR]
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- 2021
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12. Modeling Interactions among Migration, Growth and Pressure in Tumor Dynamics.
- Author
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Blanco, Beatriz, Campos, Juan, Melchor, Juan, and Soler, Juan
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TUMOR growth , *PARTIAL differential equations , *POROUS materials , *PSYCHOLOGICAL feedback , *METASTASIS , *ELASTICITY - Abstract
What are the biomechanical implications in the dynamics and evolution of a growing solid tumor? Although the analysis of some of the biochemical aspects related to the signaling pathways involved in the spread of tumors has advanced notably in recent times, their feedback with the mechanical aspects is a crucial challenge for a global understanding of the problem. The aim of this paper is to try to illustrate the role and the interaction between some evolutionary processes (growth, pressure, homeostasis, elasticity, or dispersion by flux-saturated and porous media) that lead to collective cell dynamics and defines a propagation front that is in agreement with the experimental data. The treatment of these topics is approached mainly from the point of view of the modeling and the numerical approach of the resulting system of partial differential equations, which can be placed in the context of the Hele-Shaw-type models. This study proves that local growth terms related to homeostatic pressure give rise to retrograde diffusion phenomena, which compete against migration through flux-saturated dispersion terms. [ABSTRACT FROM AUTHOR]
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- 2021
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13. Subcritical Water Extraction of Phenolic Compounds from Onion Skin Wastes (Allium cepa cv. Horcal): Effect of Temperature and Solvent Properties.
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Benito-Román, Óscar, Blanco, Beatriz, Sanz, María Teresa, and Beltrán, Sagrario
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ONIONS ,PHENOLS ,TEMPERATURE effect ,QUERCETIN ,AGRICULTURAL wastes ,WATER temperature ,FLAVONOIDS - Abstract
The valorization of onion skin wastes (OSW) through the extraction, identification, and quantification of phenolic compounds was studied in this work, using subcritical water in a semicontinuous extractor (2.5 mL/min; 105–180 °C; 5 MPa). The extraction of flavonoids resulted to be fast (<30 min) and temperature sensitive (maximum at 145 °C; total flavonoids, 27.4 ± 0.9 mg/g dry OSW (DOSW)). The experimental results were fitted to the Weibull model. The influence of the solvent properties on the flavonoids quantification was found to be critical. A precipitate was formed once the extracts cooled down. If removed, a significant fraction of the high temperature extracted flavonoids (as much as 71%, at 180 °C) was lost. Such a condition affected especially those compounds that show extremely low solubility in water at room temperature, whereas quercetin glycosylated derivatives were less affected by the polarity change of the medium induced by the temperature change. It was demonstrated that it is necessary to re-dissolve the subcritical water extracts by the addition of ethanol, which led to a medium with a polarity equivalent to that obtained with water at high temperature. At 145 °C, quercetin (15.4 ± 0.4 mg/g DOSW) and quercetin-4′-glucoside (8.4 ± 0.1 mg/g DOSW) accounted for the 90% of the total flavonoids identified. By recovering high added value bioactive compounds from OSW the principles of circular economy were fulfilled, providing a new use for this agricultural waste. [ABSTRACT FROM AUTHOR]
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- 2020
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14. Scoping Review of Kaizen and Green Practices: State of the Art and Future Directions.
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Sanchez-Ruiz, Lidia, Blanco, Beatriz, Marin-Garcia, Juan A., and Diez-Busto, Elsa
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- 2020
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15. Water Ultrasound-Assisted Extraction of Polyphenol Compounds from Brewer's Spent Grain: Kinetic Study, Extract Characterization, and Concentration.
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Alonso-Riaño, Patricia, Sanz Diez, María Teresa, Blanco, Beatriz, Beltrán, Sagrario, Trigueros, Ester, and Benito-Román, Oscar
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GRAIN ,PHENOLS ,CARBOHYDRATES ,MONOSACCHARIDES ,PHENOLIC acids ,EXTRACTS - Abstract
Brewer's spent grain (BSG) was chemically characterized obtaining 52.1% of carbohydrates, 17.8% protein, 5.9% lipids, 13.5% insoluble lignin and 24.3% of water-soluble extractives. This work has been focused on the study of polyphenol extraction of the extractive fraction by water ultrasound-assisted extraction. Selected extraction conditions were 47 °C and 21.7 mL water/g
dry-BSG . The effect of solvent polarity on polyphenol extraction was studied by using ethanol aqueous mixtures, from 20% to 100% ethanol. The kinetics of polyphenol extraction have been fitted to the power law and the Weibull models yielding mean values of the root mean square deviation lower than 7.5%. Extracts have been characterized in terms of quantification of individual phenolic compounds by HPLC-DAD and protein and sugar soluble fractions (glucose, xylose, and arabinose). Polyphenol profile has been compared with other hydrolytic techniques, such as acid, basic and enzymatic hydrolysis, showing that ultrasound was not as effective as basic hydrolysis to release the phenolic acids esterified to the cell wall. A further centrifuge ultrafiltration concentration step was able to yield a retentate enriched in the protein fraction while individual phenolic compounds where mainly transferred to the permeate. [ABSTRACT FROM AUTHOR]- Published
- 2020
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16. Modeling Interactions among Migration, Growth and Pressure in Tumor Dynamics
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Juan Campos, Juan José Soler, Juan Melchor, Beatriz Blanco, [Blanco, Beatriz] Univ Granada, Dept Struct Mech, Granada 18071, Spain, [Blanco, Beatriz] Ibs GRANADA, Inst Invest Biosanitaria, Granada 18012, Spain, [Melchor, Juan] Ibs GRANADA, Inst Invest Biosanitaria, Granada 18012, Spain, [Campos, Juan] Univ Granada, Fac Ciencias, Dept Matemat Aplicada, Granada 18071, Spain, [Soler, Juan] Univ Granada, Fac Ciencias, Dept Matemat Aplicada, Granada 18071, Spain, [Campos, Juan] Univ Granada, Res Unit Modelling Nat MNat, Granada 18071, Spain, [Melchor, Juan] Univ Granada, Res Unit Modelling Nat MNat, Granada 18071, Spain, [Soler, Juan] Univ Granada, Res Unit Modelling Nat MNat, Granada 18071, Spain, [Melchor, Juan] Univ Granada, Dept Stat & Operat Res, Granada 18071, Spain, MINECO-Feder (Spain), Junta de Andalucia (Spain), Instituto de Salud Carlos III, Ministry of Science, Innovation and Universities of Spain, Consejeria de Economia, Conocimiento, Empresas y Universidad, European Regional Development Fund (ERDF), [Blanco,B] Department of Structural Mechanics, University of Granada, Granada, Spain. [Blanco,B, Melchor,J] Instituto de Investigación Biosanitaria, ibs.GRANADA, Granada, Spain. [Campos,J, Soler,J] Departamento de Matemática Aplicada, Facultad de Ciencias, Universidad de Granada, Granada, Spain. [Campos,J, Melchor,J, Soler,J] Research Unit 'Modelling Nature' (MNat), Universidad de Granada, Granada, Spain., and This paper has been partially supported by the MINECO-Feder (Spain) research grant num bers RTI2018-098850-B-I00 (J.C., J.S.) & EQC2018-004508-P (B.B., J.M.), the Junta de Andalucía (Spain) Projects PY18-RT-2422 (J.C., J.S.), A-FQM-311-UGR18 (J.C., J.S.) & IE2017-5537 (B.B., J.M.), and by the Instituto de Salud Carlos III, project number DTS17/00087 (J.M., J.S.). This study was also funded by Ministry of Science, Innovation and Universities of Spain, project numbers DPI2017-85359-R (B.B., J.M.) & PID2019-106947RA-C22 (B.B., J.M.) and by Consejería de Economía, Conocimiento, Empresas y Universidad and European Regional Development Fund (ERDF), ref. SOMM17/6109/UGR (J.C., J.M., J.S.). Lastly, B.B. research was granted by Ministry of Science, Innovation and Universities of Spain, FPU2017/01415.
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Computer science ,01 natural sciences ,Forces ,Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Movement [Medical Subject Headings] ,Diffusion ,porous media ,Qualitative behavior ,Computer Science (miscellaneous) ,Numerical simulations ,Homeostasis ,Statistical physics ,Diffusion (business) ,Solid tumor ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Mortality::Cause of Death [Medical Subject Headings] ,Cancer ,0303 health sciences ,Partial differential equation ,Mathematical modelling ,Dynamics (mechanics) ,Traveling-waves ,mathematical modeling ,tumor dynamics ,Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Signal Transduction [Medical Subject Headings] ,Diseases::Neoplasms [Medical Subject Headings] ,flux-saturated ,Modelos teóricos ,General Mathematics ,Phenomena and Processes::Physical Phenomena::Mechanical Phenomena::Porosity [Medical Subject Headings] ,Context (language use) ,Information Science::Information Science::Communication::Cybernetics::Feedback [Medical Subject Headings] ,cell motility ,Stress ,Mechanics ,03 medical and health sciences ,QA1-939 ,Hele-Shaw model ,Movimiento celular ,Phenomena and Processes::Physical Phenomena::Mechanical Phenomena::Elasticity [Medical Subject Headings] ,0101 mathematics ,Engineering (miscellaneous) ,030304 developmental biology ,Computer simulation ,010102 general mathematics ,Porous-media equations ,Mass ,numerical simulation ,Floculadores ,Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Transdifferentiation::Epithelial-Mesenchymal Transition [Medical Subject Headings] ,mechanical feedback ,Phenomena and Processes::Physiological Phenomena::Physiological Processes::Homeostasis [Medical Subject Headings] ,Mathematics - Abstract
What are the biomechanical implications in the dynamics and evolution of a growing solid tumor? Although the analysis of some of the biochemical aspects related to the signaling pathways involved in the spread of tumors has advanced notably in recent times, their feedback with the mechanical aspects is a crucial challenge for a global understanding of the problem. The aim of this paper is to try to illustrate the role and the interaction between some evolutionary processes (growth, pressure, homeostasis, elasticity, or dispersion by flux-saturated and porous media) that lead to collective cell dynamics and defines a propagation front that is in agreement with the experimental data. The treatment of these topics is approached mainly from the point of view of the modeling and the numerical approach of the resulting system of partial differential equations, which can be placed in the context of the Hele-Shaw-type models. This study proves that local growth terms related to homeostatic pressure give rise to retrograde diffusion phenomena, which compete against migration through flux-saturated dispersion terms., MINECO-Feder (Spain) research grant numbers RTI2018-098850-B-I00 (J.C., J.S.) & EQC2018-004508-P (B.B., J.M.), Junta de Andalucía (Spain) Projects PY18-RT-2422 (J.C., J.S.), A-FQM-311-UGR18 (J.C., J.S.) & IE2017-5537 (B.B., J.M.), Instituto de Salud Carlos III, project number DTS17/00087 (J.M., J.S.), Ministry of Science, Innovation and Universities of Spain, project numbers DPI2017-85359-R (B.B., J.M.) & PID2019-106947RA-C22 (B.B., J.M.), Consejería de Economía, Conocimiento, Empresas y Universidad and European Regional Development Fund (ERDF), ref. SOMM17/6109/UGR (J.C., J.M., J.S.), Ministry of Science, Innovation and Universities of Spain, FPU2017/01415
- Published
- 2021
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