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Periodontitis is significantly associated with the risk of cancers in the lung and the digestive system. Emerging evidence shows a plausible link between periodontitis and several types of brain diseases. However, the association between periodontal infection and glioma remains unclear. In the cultured GL261 glioma cells, P. gingivalis lipopolysaccharide (LPS) significantly promoted cell proliferation at concentrations ranging from 10 to 1000 ng/mL. It promoted cell migration at a higher concentration (100 and 1000 ng/mL). Additionally, exposure to 100 ng/mL P. gingivalis LPS induced a significant increase in the expression of TNF-α, TGF-β, MMP2, and MMP9, as well as the phosphorylation level of Akt at Ser473. These changes induced by P. gingivalis LPS were significantly antagonized by the Akt inhibitor. Furthermore, a total of 48 patients with brain tumors were enrolled to investigate their periodontal status before receiving tumor management. Poor periodontal status [probing depth (PD) ≥ 6 mm and attachment loss (AL) >5 mm] was found in 42.9% (9/21) of patients with glioma, which was significantly higher than that in patients with benign tumors and the relevant data in the 4th National Oral Health Survey in China. The glioma patients with both AL > 5 mm and PD ≥ 6 mm had a higher ki-67 labeling index than those with AL ≤ 5 mm or PD < 6 mm. These findings support the association between periodontal infection and glioma progression. [ABSTRACT FROM AUTHOR]

The recently proposed restricted phase space thermodynamics is shown to be applicable to a large class of higher dimensional higher curvature gravity models coupled to Maxwell field, which are known as black hole scan models and are labeled by the spacetime dimension d and the highest order k of the Lanczos-Lovelock densities appearing in the action. Three typical example cases with (d , k) = (5 , 1) , (5 , 2) and (6 , 2) are chosen as example cases and studied in some detail. These cases are representatives of Einstein-Hilbert, Chern-Simons and Born-Infield like gravity models. Our study indicates that the Einstein-Hilbert and Born-Infield like gravity models have similar thermodynamic behaviors, e.g., the existence of isocharge T − S phase transitions with the same critical exponents, the existence of isovoltage T − S transitions and the Hawking-Page like transitions, and the similar high temperature asymptotic behaviors for the isocharge heat capacities, etc. However, the Chern-Simons like (5 , 2) -model behaves quite differently. Neither isocharge nor isovoltage T − S transitions could occur and no Hawking-Page like transition is allowed. This seems to indicate that the Einstein-Hilbert and Born-Infield like models belong to the same universality class while the Chern-Simons like models do not. [ABSTRACT FROM AUTHOR]