1. Untargeted Metabolomics Used to Describe the Chemical Composition, Antioxidant and Antimicrobial Effects of Extracts from Pleurotus spp. Mycelium Grown in Different Culture Media
- Author
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Giancarlo Angeles Flores, Carolina Elena Girometta, Gaia Cusumano, Paola Angelini, Bruno Tirillini, Federica Ianni, Francesca Blasi, Lina Cossignani, Roberto Maria Pellegrino, Carla Emiliani, Roberto Venanzoni, Giuseppe Venturella, Pasqualina Colasuonno, Fortunato Cirlincione, Maria Letizia Gargano, Gokhan Zengin, Alessandra Acquaviva, Simonetta Cristina Di Simone, Giustino Orlando, Luigi Menghini, Claudio Ferrante, Flores, GA, Girometta, CE, Cusumano, G, Angelini, P, Tirillini, B, Ianni, F, Blasi, F, Cossignani, L, Pellegrino, RM, Emiliani, C, Venanzoni, R, Venturella, G, Colasuonno, P, Cirlincione, F, Gargano, ML, Zengin, G, Acquaviva, A, Di Simone, SC, Orlando, G, Menghini, L, and Ferrante, C
- Subjects
Microbiology (medical) ,Pleurotus specie ,Pleurotus species ,phenolic compounds ,metabolomics ,Biochemistry ,Microbiology ,Infectious Diseases ,antimicrobial effect ,Settore BIO/03 - Botanica Ambientale E Applicata ,Pharmacology (medical) ,General Pharmacology, Toxicology and Pharmaceutics ,metabolomic - Abstract
Pleurotus species isolated in vitro were studied to determine the effect of different media on their production of secondary metabolites, antimicrobial, and antioxidant activity. The different metabolites among Pleurotus samples covered a total of 58 pathways. Comparisons were made between the metabolic profiles of Pleurotus spp. mycelia grown in two substrates: Potato-dextrose-agar-PDA, used as control (S1), and PDA enriched with 0.5 % of wheat straw (S2). The main finding was that the metabolic pathways are strongly influenced by the chemical composition of the growth substrate. The antibacterial effects were particularly evident against Escherichia coli, whereas Arthroderma curreyi (CCF 5207) and Trichophyton rubrum (CCF 4933) were the dermatophytes more sensitive to the mushroom extracts. The present study supports more in-depth investigations, aimed at evaluating the influence of growth substrate on Pleurotus spp. antimicrobial and antioxidant properties.
- Published
- 2022