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Ferroptosis is an iron-dependent and lipid peroxidation-driven cell death cascade, occurring when there is an imbalance of redox homeostasis in the cell. Nuclear factor erythroid 2-related factor 2 (NFE2L2, also known as NRF2) is key for cellular antioxidant responses, which promotes downstream genes transcription by binding to their antioxidant response elements (AREs). Numerous studies suggest that NRF2 assumes an extremely important role in the regulation of ferroptosis, for its various functions in iron, lipid, and amino acid metabolism, and so on. Many pathological states are relevant to ferroptosis. Abnormal suppression of ferroptosis is found in many cases of cancer, promoting their progression and metastasis. While during tissue damages, ferroptosis is recurrently promoted, resulting in a large number of cell deaths and even dysfunctions of the corresponding organs. Therefore, targeting NRF2-related signaling pathways, to induce or inhibit ferroptosis, has become a great potential therapy for combating cancers, as well as preventing neurodegenerative and ischemic diseases. In this review, a brief overview of the research process of ferroptosis over the past decade will be presented. In particular, the mechanisms of ferroptosis and a focus on the regulation of ferroptosis by NRF2 will be discussed. Finally, the review will briefly list some clinical applications of targeting the NRF2 signaling pathway in the treatment of diseases. [ABSTRACT FROM AUTHOR]

Inspired by the difference in the friction radii of the pads from the high-speed train brake system, stick–slip experiments for a disc–block friction system with different friction radii were carried out via a test device. Based on the test results, the stick–slip vibration characteristics of the disc–block friction system with variation in the friction radius were analyzed, and the corresponding Stribeck model parameters in exponential and fractional forms were identified. The experimental results show that with an increase in the friction radius the vibration amplitude first increased and then decreased and the frequency of stick–slip vibration increased. The identified Stribeck model parameters show that the decay factors increased, the static friction coefficient decreased, and the dynamic friction coefficient decreased first and then increased as the friction radius increased. Moreover, the identified Stribeck model in an exponential form can more accurately reflect the stick–slip characteristics of a disc–block friction system than the model in a fractional form. It can be further applied in the investigation of the dynamic behaviors of high-speed train brake systems. [ABSTRACT FROM AUTHOR]