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2. Salicylanilide acetates: synthesis and antibacterial evaluation.

Author

Vinsova J, Imramovsky A, Buchta V, Ceckova M, Dolezal M, Staud F, Jampilek J, and Kaustova J

Subjects
Anti-Bacterial Agents chemistry, Antifungal Agents chemical synthesis, Antifungal Agents chemistry, Antifungal Agents pharmacology, Candida albicans drug effects, Cell Line, Cell Survival drug effects, Fluconazole pharmacology, Humans, Microbial Sensitivity Tests, Microbial Viability drug effects, Molecular Structure, Mycobacterium drug effects, Salicylanilides chemistry, Structure-Activity Relationship, Anti-Bacterial Agents chemical synthesis, Anti-Bacterial Agents pharmacology, Salicylanilides chemical synthesis, Salicylanilides pharmacology
Abstract

A new series of salicylanilide acetates was synthesized and evaluated for their in vitro antifungal and antituberculotic activity. Some of the evaluated compounds possessed comparable or better antifungal activity than a fluconazole standard. All these compounds exhibited very good potential and their in vitro activity against drug resistant and sensitive clinical isolates of Mycobacteria were found to be equivalent or better than a standard of isoniazide, a well-known first-line drug for tuberculosis treatment.

Published
2007
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