1. Ocellatuperoxides A–F, Uncommon Anti-Tumoral γ -Pyrone Peroxides from a Photosynthetic Mollusk Placobranchus ocellatus.
- Author
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Li, Song-Wei, Wu, Qihao, Xu, Heng, Yao, Li-Gong, Luo, Cheng, Wang, Hong, Zhang, Hao, Li, Xu-Wen, and Guo, Yue-Wei
- Abstract
Six new pairs of γ-pyrone polypropionate enantiomers with an unusual peroxyl bridge at the side chain, namely (±)-ocellatuperoxides A–F (1–6), were isolated and characterized from the South China Sea photosynthetic mollusk Placobranchus ocellatus. Extensive spectroscopic analysis, single crystal X-ray diffraction analysis, ECD- (electronic circular dichroism) comparison, and TDDFT (time-dependent density functional theory) ECD computation were used to determine the structures and absolute configurations of new compounds. In a cell viability assay, several compounds showed considerable anti-tumoral effects on human non-small cell lung cancer cells A549 with Gefitinib (7.4 μM) and Erlotinib (2.1 μM) as positive controls. Further RNA-sequencing analysis and gene expression evaluation indicated that the anti-tumoral activity of the most effective compound 3 was associated with the regulation of several important genes, such as FGFR1 and HDAC5. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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