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For tailoring the mechanical and magnetic properties of dual-phase high-entropy alloys (HEAs), it is crucial to understand the effect of each phase on the overall properties. In this paper, the effects of individual FCC and BCC phases on the mechanical and magnetic properties of the FeCoNi(CuAl)0.8 HEA are investigated by nanoindentation and first-principles calculations. The nano-hardness of the BCC phase is 8.73 GPa, which is nearly double the 4.60 GPa of the FCC phase, which ascribes to spherical nanoprecipitates that are only observed in the BCC phase leading to precipitation hardening. First-principles calculations on the electronic structure show that calculated saturation magnetization (Ms) of the BCC phase is 0.81 T, higher than 0.77 T of the FCC phase. An approximate yield strength and Ms can be estimated by summing the volume-fraction-weighted contributions from each phase, and are in good agreement with experimental values. It indicates that the overall mechanical and magnetic properties of the dual-phase HEAs can be tailored by tuning the volume fraction of the individual phase. Our findings are helpful to design prospective dual-phase HEAs with both good mechanical properties and soft magnetic performance by adjusting the content of each phase. [ABSTRACT FROM AUTHOR]

miRNAs have emerged as promising markers for tumors. However, the underlying mechanism of specific miRNAs in bladder cancer (BC) remains largely unknown. Here, a comprehensive miRNA/mRNA expression profile was executed by microarray assay for four pairs of bladder carcinoma and para-carcinoma tissues from patients with grade 2 (G2) T2. A total of 99 miRNAs and 4416 mRNAs were discovered to be significantly differentially expressed in BC tissues compared with controls. Five microRNAs and two mRNAs were validated by qRT-PCR in 30 pairs of samples, including G1-G3/T1-T4. Subsequently, we constructed a network with the five miRNAs-target mRNAs; gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were utilized to recognize the functions and associated pathways. Moreover, we further found that miR-130b-3p was significantly up-regulated and negatively correlated with phosphatase and tensin homolog (PTEN) expression in bladder cancer tissues. Next, we demonstrated that miR-130b-3p might target PTEN through bioinformatics and dual-luciferase reporter assay. Finally, we showed that miR-130b-3p could down-regulate PTEN expression, which promoted proliferation, migration, invasion and rearranged cytoskeleton through the activation of the PI3K and integrin β1 signaling pathway in bladder cancer cells. Inversely, miR-130b-3p inhibitors induced apoptosis. Taken together, this research investigated, for the first time, miR-130b-3p by an incorporated analysis of microRNA/mRNA expressions of a genome-wide screen in BC. Our findings suggest that the miR-130b-3p/PTEN/integrin β1 axis could play a critical role in the progression and development of BC and that miR-130b-3p might be a valuable clinical marker and therapeutical target for BC patients., Competing Interests: The authors declare no conflict of interest.