1. Multifunctional Nanoparticles with Superparamagnetic Mn(II) Ferrite and Luminescent Gold Nanoclusters for Multimodal Imaging.
- Author
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Casteleiro, Bárbara, Rocha, Mariana, Sousa, Ana R., Pereira, André M., Martinho, José M. G., Pereira, Clara, and Farinha, José P. S.
- Subjects
GOLD clusters ,SUPERPARAMAGNETIC materials ,SILICA nanoparticles ,STOKES shift ,NANOPARTICLES ,ELECTRONIC excitation ,MESOPOROUS silica ,FERRITES - Abstract
Gold nanoclusters (AuNCs) with fluorescence in the Near Infrared (NIR) by both one- and two-photon electronic excitation were incorporated in mesoporous silica nanoparticles (MSNs) using a novel one-pot synthesis procedure where the condensation polymerization of alkoxysilane monomers in the presence of the AuNCs and a surfactant produced hybrid MSNs of 49 nm diameter. This method was further developed to prepare 30 nm diameter nanocomposite particles with simultaneous NIR fluorescence and superparamagnetic properties, with a core composed of superparamagnetic manganese (II) ferrite nanoparticles (MnFe
2 O4 ) coated with a thin silica layer, and a shell of mesoporous silica decorated with AuNCs. The nanocomposite particles feature NIR-photoluminescence with 0.6% quantum yield and large Stokes shift (290 nm), and superparamagnetic response at 300 K, with a saturation magnetization of 13.4 emu g−1 . The conjugation of NIR photoluminescence and superparamagnetic properties in the biocompatible nanocomposite has high potential for application in multimodal bioimaging. [ABSTRACT FROM AUTHOR]- Published
- 2023
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