1. The Serum Metabolome of Moderate and Severe COVID-19 Patients Reflects Possible Liver Alterations Involving Carbon and Nitrogen Metabolism
- Author
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Anna Annunziata, Francesco Maria Fusco, Alessandro Di Minno, Margherita Ruoppolo, Giuseppe Castaldo, Chiara Dell’Isola, Roberta Russo, Armando Cevenini, Immacolata Andolfo, Mario Capasso, Giuseppe Fiorentino, Roberta Fedele, Gabriella Fabbrocini, Cecilia Calabrese, Marianna Caterino, Michele Costanzo, Ivan Gentile, Monica Gelzo, Roberto Parrella, Maurizio D’Abbraccio, Caterino, Marianna, Costanzo, Michele, Fedele, Roberta, Cevenini, Armando, Gelzo, Monica, DI MINNO, Alessandro, Andolfo, Immacolata, Capasso, Mario, Russo, Roberta, Annunziata, Anna, Calabrese, Cecilia, Fiorentino, Giuseppe, D’Abbraccio, Maurizio, Dell’Isola, Chiara, Maria Fusco, Francesco, Parrella, Roberto, Fabbrocini, Gabriella, Gentile, Ivan, Castaldo, Giuseppe, Ruoppolo, Margherita, Caterino, M., Costanzo, M., Fedele, R., Cevenini, A., Gelzo, M., Di Minno, A., Andolfo, I., Capasso, M., Russo, R., Annunziata, A., Calabrese, C., Fiorentino, G., D'Abbraccio, M., Dell'Isola, C., Fusco, F. M., Parrella, R., Fabbrocini, G., Gentile, I., Castaldo, G., and Ruoppolo, M.
- Subjects
coronavirus ,Physiology ,Disease ,medicine.disease_cause ,Severity of Illness Index ,Medicine ,Biology (General) ,Amino Acids ,Spectroscopy ,Coronavirus ,mass spectrometry ,Discriminant Analysis ,General Medicine ,metabolomics ,Pathophysiology ,Computer Science Applications ,Amino Acid ,Chemistry ,Liver ,Metabolome ,Cytokines ,Discriminant Analysi ,Metabolic Networks and Pathways ,Human ,QH301-705.5 ,Nitrogen ,Coronaviru ,Context (language use) ,Metabolomic ,serum cytokines ,Catalysis ,Article ,Inorganic Chemistry ,Metabolomics ,Severity of illness ,Humans ,Physical and Theoretical Chemistry ,Least-Squares Analysis ,Serum cy-tokine ,Cytokine ,Molecular Biology ,QD1-999 ,Least-Squares Analysi ,business.industry ,SARS-CoV-2 ,Organic Chemistry ,lactic acid ,Metabolic Networks and Pathway ,COVID-19 ,Biomarker ,Metabolism ,Carbon ,business ,Biomarkers - Abstract
COVID-19 is a global threat that has spread since the end of 2019, causing severe clinical sequelae and deaths, in the context of a world pandemic. The infection of the highly pathogenetic and infectious SARS-CoV-2 coronavirus has been proven to exert systemic effects impacting the metabolism. Yet, the metabolic pathways involved in the pathophysiology and progression of COVID-19 are still unclear. Here, we present the results of a mass spectrometry-based targeted metabolomic analysis on a cohort of 52 hospitalized COVID-19 patients, classified according to disease severity as mild, moderate, and severe. Our analysis defines a clear signature of COVID-19 that includes increased serum levels of lactic acid in all the forms of the disease. Pathway analysis revealed dysregulation of energy production and amino acid metabolism. Globally, the variations found in the serum metabolome of COVID-19 patients may reflect a more complex systemic perturbation induced by SARS-CoV-2, possibly affecting carbon and nitrogen liver metabolism.
- Published
- 2021