1. High Mobility Group A (HMGA): Chromatin Nodes Controlled by a Knotty miRNA Network
- Author
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Rossella Zanin, Riccardo Sgarra, Gloria Ros, Daniela D'Angelo, Michela Sgubin, Sabrina Battista, Guidalberto Manfioletti, Silvia Pegoraro, Sara Petrosino, Sgarra, R, Pegoraro, S, D'Angelo, D, Ros, G, Zanin, R, Sgubin, M, Petrosino, S, Battista, S, and Manfioletti, G
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0301 basic medicine ,High mobility group A ,miRNA ,post-transcriptional regulation ,cancer ,[object Object] ,Computational biology ,Review ,Biology ,Catalysis ,lcsh:Chemistry ,Inorganic Chemistry ,03 medical and health sciences ,0302 clinical medicine ,Neoplasms ,microRNA ,Gene expression ,Animals ,Humans ,Physical and Theoretical Chemistry ,lcsh:QH301-705.5 ,Molecular Biology ,Post-transcriptional regulation ,Gene ,Spectroscopy ,HMGA Proteins ,Organic Chemistry ,HMGA ,General Medicine ,Chromatin ,Computer Science Applications ,Gene Expression Regulation, Neoplastic ,MicroRNAs ,030104 developmental biology ,High-mobility group ,lcsh:Biology (General) ,lcsh:QD1-999 ,030220 oncology & carcinogenesis ,Cancer cell - Abstract
High mobility group A (HMGA) proteins are oncofoetal chromatin architectural factors that are widely involved in regulating gene expression. These proteins are unique, because they are highly expressed in embryonic and cancer cells, where they play a relevant role in cell proliferation, stemness, and the acquisition of aggressive tumour traits, i.e., motility, invasiveness, and metastatic properties. The HMGA protein expression levels and activities are controlled by a connected set of events at the transcriptional, post-transcriptional, and post-translational levels. In fact, microRNA (miRNA)-mediated RNA stability is the most-studied mechanism of HMGA protein expression modulation. In this review, we contribute to a comprehensive overview of HMGA-targeting miRNAs; we provide detailed information regarding HMGA gene structural organization and a comprehensive evaluation and description of HMGA-targeting miRNAs, while focusing on those that are widely involved in HMGA regulation; and, we aim to offer insights into HMGA-miRNA mutual cross-talk from a functional and cancer-related perspective, highlighting possible clinical implications.
- Published
- 2020
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