1. Lipid Nanoparticles for the Posterior Eye Segment
- Author
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Lorena Bonilla, Marta Espina, Patricia Severino, Amanda Cano, Miren Ettcheto, Antoni Camins, Maria Luisa García, Eliana B. Souto, Elena Sánchez-López, and Universidade do Minho
- Subjects
drug transport ,Ocular pharmacology ,genetic structures ,Pharmaceutical Science ,SLN ,02 engineering and technology ,Review ,lipid nanoparticles ,posterior segment ,030226 pharmacology & pharmacy ,ocular drug delivery ,03 medical and health sciences ,0302 clinical medicine ,Pharmacy and materia medica ,Administration of drugs ,Science & Technology ,Nanopartícules ,021001 nanoscience & nanotechnology ,eye diseases ,3. Good health ,Drug delivery systems ,RS1-441 ,Farmacologia ocular ,Sistemes d'alliberament de medicaments ,ocular barriers ,Nanoparticles ,NLC ,lipids (amino acids, peptides, and proteins) ,Administració de medicaments ,sense organs ,0210 nano-technology - Abstract
This review highlights the application of lipid nanoparticles (Solid Lipid Nanoparticles, Nanostructured Lipid Carriers, or Lipid Drug Conjugates) as effective drug carriers for pathologies affecting the posterior ocular segment. Eye anatomy and the most relevant diseases affecting the posterior segment will be summarized. Moreover, preparation methods and different types and subtypes of lipid nanoparticles will also be reviewed. Lipid nanoparticles used as carriers to deliver drugs to the posterior eye segment as well as their administration routes, pharmaceutical forms and ocular distribution will be discussed emphasizing the different targeting strategies most recently employed for ocular drug delivery., This research was funded by the Portuguese Science and Technology Foundation (FCT/MCT) and European Funds (PRODER/COMPETE), under the project reference UIDB/04469/2020 (strategic fund), co-financed by FEDER, under the Partnership Agreement PT2020., info:eu-repo/semantics/publishedVersion more...
- Published
- 2021