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In order to ensure the security and stability of oilfield gathering and transportation stations and to improve the risk assessment method, this paper proposes an evaluation method that can fully and quantitatively calculate the impact range of process equipment and pipelines in the event of fire and explosion accidents based on API 581-2016 Quantitative Risk Assessment Technology. It mainly analyzes and calculates the leakage type, leakage rate and total leakage amount, combined with the occurrence probability of various failure situations, the casualty area and the fact that equipment damage could be finally determined. In addition, PHAST Software is used to verify this method. The average deviation of the calculation results is very small, which shows that the method is completely feasible and accurate. In order to further correct the error, specific correction methods and formulas are also proposed. This theoretical calculation method greatly improves the quantitative evaluation method of oil field gathering and transportation stations, and lays a solid foundation for the quantitative calculation of failure consequences in the future. [ABSTRACT FROM AUTHOR]

The general control of nucleotide synthesis 5 (GCN5), which is one kind of lysine acetyltransferases, regulates a number of cellular processes, such as cell proliferation, differentiation, cell cycle and DNA damage repair. However, its biological role in human glioma development remains elusive. In the present study, we firstly reported that GCN5 was frequently overexpressed in human glioma tissues and GCN5 was positively correlated with proliferation of cell nuclear antigen PCNA and matrix metallopeptidase MMP9. Meanwhile, down-regulation of GCN5 by siRNA interfering inhibited glioma cell proliferation and invasion. In addition, GCN5 knockdown reduced expression of p-STAT3, p-AKT, PCNA and MMP9 and increased the expression of p21 in glioma cells. In conclusion, GCN5 exhibited critical roles in glioma development by regulating cell proliferation and invasion, which suggested that GCN5 might be a potential molecular target for glioma treatment.