1. Statistical Models for High-Risk Intestinal Metaplasia with DNA Methylation Profiling.
- Author
-
Wang, Tianmeng, Huang, Yifei, and Yang, Jie
- Subjects
DNA methylation ,STATISTICAL models ,METAPLASIA ,INTESTINES ,CELL division - Abstract
We consider the newly developed multinomial mixed-link models for a high-risk intestinal metaplasia (IM) study with DNA methylation data. Different from the traditional multinomial logistic models commonly used for categorical responses, the mixed-link models allow us to select the most appropriate link function for each category. We show that the selected multinomial mixed-link model (Model 1) using the total number of stem cell divisions (TNSC) based on DNA methylation data outperforms the traditional logistic models in terms of cross-entropy loss from ten-fold cross-validations with significant p-values 8.12 × 10 − 4 and 6.94 × 10 − 5 . Based on our selected model, the significance of TNSC's effect in predicting the risk of IM is justified with a p-value less than 10 − 6 . We also select the most appropriate mixed-link models (Models 2 and 3) when an additional covariate, the status of gastric atrophy, is available. When the status is negative, mild, or moderate, we recommend Model 2; otherwise, we prefer Model 3. Both Models 2 and 3 can predict the risk of IM significantly better than Model 1, which justifies that the status of gastric atrophy is informative in predicting the risk of IM. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF