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Bacterial resistance to antibiotics and host defense systems is primarily due to bacterial biofilm formation in antibiotic therapy. In the present study, two complexes, bis (biphenyl acetate) bipyridine Cu (II) (1) and bis (biphenyl acetate) bipyridine Zn (II) (2), were tested for their ability to prevent biofilm formation. The minimum inhibitory concentration and minimum bactericidal concentration of complexes 1 and 2 were 46.87 ± 1.822 and 93.75 ± 1.345 and 47.87 ± 1.345 and 94.85 ± 1.466 μg/mL, respectively. The significant activity of both complexes was attributed to the damage caused at the membrane level and was confirmed using an imaging technique. The biofilm inhibitory potential levels of complexes 1 and 2 were 95% and 71%, respectively, while the biofilm eradication potential levels were 95% and 35%, respectively, for both complexes. Both the complexes showed good interactions with the E. coli DNA. Thus, complexes 1 and 2 are good antibiofilm agents that exert their bactericidal actions possibly by disrupting the bacterial membrane and interacting with the bacterial DNA, which can act as a powerful agent to restrain the development of bacterial biofilm on therapeutic implants. [ABSTRACT FROM AUTHOR]

Featured Application: The current study deals with the growing challenge of droughts in a changing climate. The analysis of drought trends in one of the most vulnerable regions in Pakistan and Balochistan reveals insights into the evolving characteristics of droughts in different parts of the region. The findings will prove useful for water resource managers. Drought is a severe threat, especially in the arid regions of Pakistan, such as the Balochistan Province. The aim of this study is to analyze drought trends in Balochistan using Standard Precipitation Index (SPI) at the 3-month accumulation timescale. The monthly rainfall data of 10 stations were collected from the Pakistan Meteorological Department (PMD) for 37 years (1980–2017). Drought trends were analyzed at each station using the Mann-Kendall test. The SPI identified extreme drought events in 1996, 2001, 2002, 2004, 2009, and 2014. Barkhan was the station that most frequently experienced extreme to severe drought events, as defined using SPI. A statistically significant decreasing precipitation trend was found in four stations (Dalbandin, Jiwani, Quetta, and Zhob). The analysis of drought characteristics showed Barkhan faced the most prolonged drought, of 22 months from 1999 to 2001. The findings from the present study can give guidance on how strategies of water management should be adjusted based on the changing patterns of droughts in the Balochistan Province. [ABSTRACT FROM AUTHOR]