1. Synthesis and Structural Characterization of Silver Nanoparticles Stabilized with 3-Mercapto-1-Propansulfonate and 1-Thioglucose Mixed Thiols for Antibacterial Applications
- Author
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Wojciech Olszewski, Carlo Meneghini, Laura Simonelli, Carlo Marini, Igor Luisetto, Chiara Battocchio, Nitya Ramanan, Iole Venditti, Daniela Visaggio, Andrea Ugolini, Laura Carlini, Ilaria Fratoddi, Francesco Porcaro, Paolo Visca, Porcaro, Francesco, Carlini, Laura, Ugolini, Andrea, Visaggio, Daniela, Visca, Paolo, Fratoddi, Ilaria, Venditti, Iole, Meneghini, Carlo, Simonelli, Laura, Marini, Carlo, Olszewski, Wojciech, Ramanan, Nitya, Luisetto, Igor, and Battocchio, Chiara
- Subjects
silver nanoparticles ,Materials science ,Absorption spectroscopy ,Silver nanoparticle ,antibacterial activity ,hydrophilic ligands ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,lcsh:Technology ,materials science (all) ,Article ,Hydrophilic ligand ,Metal ,Dynamic light scattering ,X-ray photoelectron spectroscopy ,Nanobiotechnology ,Organic chemistry ,General Materials Science ,lcsh:Microscopy ,lcsh:QC120-168.85 ,X-ray absorption spectroscopy ,lcsh:QH201-278.5 ,lcsh:T ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,lcsh:TA1-2040 ,visual_art ,visual_art.visual_art_medium ,lcsh:Descriptive and experimental mechanics ,lcsh:Electrical engineering. Electronics. Nuclear engineering ,Antibacterial activity ,Materials Science (all) ,0210 nano-technology ,lcsh:Engineering (General). Civil engineering (General) ,lcsh:TK1-9971 ,Nuclear chemistry - Abstract
The synthesis, characterization and assessment of the antibacterial properties of hydrophilic silver nanoparticles (AgNPs) were investigated with the aim to probe their suitability for innovative applications in the field of nanobiotechnology. First, silver nanoparticles were synthetized and functionalized with two capping agents, namely 3-mercapto-1-propansulfonate (3MPS) and 1-β-thio-d-glucose (TG). The investigation of the structural and electronic properties of the nano-systems was carried out by means of X-ray Photoelectron Spectroscopy (XPS) and X-ray Absorption Spectroscopy (XAS). XPS data provided information about the system stability and the interactions between the metallic surface and the organic ligands. In addition, XPS data allowed us to achieve a deep understanding of the influence of the thiols stoichiometric ratio on the electronic properties and stability of AgNPs. In order to shed light on the structural and electronic local properties at Ag atoms sites, XAS at Ag K-Edge was successfully applied; furthermore, the combination of Dynamic Light Scattering (DLS) and XAS results allowed determining AgNPs sizes, ranging between 3 and 13 nm. Finally, preliminary studies on the antibacterial properties of AgNPs showed promising results on four of six multidrug-resistant bacteria belonging to the ESKAPE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter sp.).
- Published
- 2016