1. Associations of preconception exposure to air pollution and greenness with offspring asthma and hay fever
- Author
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Joachim Heinrich, Ingrid Nordeide Kuiper, Randi Jacobsen Bertelsen, Christer Janson, Kees de Hoogh, Thomas Halvorsen, Ole Hertel, Lennart Bråbäck, Jesper H. Christensen, Simone Accordini, Cecilie Svanes, Torben Sigsgaard, Alessandro Marcon, Bertil Forsberg, Gerard Hoek, Iana Markevych, Mathias Holm, Ane Johannessen, and A. Malinovschi
- Subjects
air pollution ,childhood asthma ,childhood hay fever ,greenness ,preconception exposure ,Male ,Allergy ,Health, Toxicology and Mutagenesis ,Respiratory Medicine and Allergy ,lcsh:Medicine ,010501 environmental sciences ,Logistic regression ,01 natural sciences ,0302 clinical medicine ,Pregnancy ,030212 general & internal medicine ,Child ,Lungmedicin och allergi ,Air Pollutants ,3. Good health ,Europe ,Child, Preschool ,Paternal Exposure ,Hay fever ,Female ,Maternal Inheritance ,Adolescent ,Offspring ,Nitrogen Dioxide ,Environment ,Article ,03 medical and health sciences ,Arbetsmedicin och miljömedicin ,medicine ,Humans ,0105 earth and related environmental sciences ,Asthma ,business.industry ,lcsh:R ,Public Health, Environmental and Occupational Health ,Australia ,Infant, Newborn ,Infant ,Rhinitis, Allergic, Seasonal ,Odds ratio ,Occupational Health and Environmental Health ,Environmental Exposure ,medicine.disease ,Preconception Injuries ,13. Climate action ,Spain ,Particulate Matter ,business ,Demography - Abstract
We investigated if greenness and air pollution exposure in parents&rsquo, childhood affect offspring asthma and hay fever, and if effects were mediated through parental asthma, pregnancy greenness/pollution exposure, and offspring exposure. We analysed 1106 parents with 1949 offspring (mean age 35 and 6) from the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) generation study. Mean particulate matter (PM2.5 and PM10), nitrogen dioxide (NO2), black carbon (BC), ozone (O3) (µ, g/m3) and greenness (normalized difference vegetation index (NDVI)) were calculated for parents 0&ndash, 18 years old and offspring 0&ndash, 10 years old, and were categorised in tertiles. We performed logistic regression and mediation analyses for two-pollutant models (clustered by family and centre, stratified by parental lines, and adjusted for grandparental asthma and education). Maternal medium PM2.5 and PM10 exposure was associated with higher offspring asthma risk (odds ratio (OR) 2.23, 95%CI 1.32&ndash, 3.78, OR 2.27, 95%CI 1.36&ndash, 3.80), and paternal high BC exposure with lower asthma risk (OR 0.31, 95%CI 0.11&ndash, 0.87). Hay fever risk increased for offspring of fathers with medium O3 exposure (OR 4.15, 95%CI 1.28&ndash, 13.50) and mothers with high PM10 exposure (OR 2.66, 95%CI 1.19&ndash, 5.91). The effect of maternal PM10 exposure on offspring asthma was direct, while for hay fever, it was mediated through exposures in pregnancy and offspring&rsquo, s own exposures. Paternal O3 exposure had a direct effect on offspring hay fever. To conclude, parental exposure to air pollution appears to influence the risk of asthma and allergies in future offspring.
- Published
- 2020
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