1. Antibacterial and Antitumor Activities of Biscoumarin and Dihydropyran Derivatives.
- Author
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Yun-Peng Sui, Hai-Ru Huo, Jia-Jia Xin, Jing Li, Xiao-Jun Li, Xin-Liang Du, Hai Ma, Hai-Yu Zhou, Hong-Dan Zhan, Zhu-Ju Wang, Chun Li, Feng Sui, and Ming-Kai Li
- Subjects
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ANTIBACTERIAL agents , *TUMOR treatment , *CONDENSATION reactions , *CRYSTAL structure , *X-ray crystallography , *DENSITY functional theory , *HYDROGEN bonding - Abstract
A novel series of biscoumarin (1-4) and dihydropyran (5-13) derivatives were synthesized via a one-pot multicomponent condensation reaction and evaluated for antibacterial and antitumor activity in vitro. The X-ray crystal structure analysis of four representative compounds, 3, 7, 9 and 11, confirmed the structures of these compounds. Compounds 1-4 showed the most potent antitumor activity among the total 13 derivatives; especially for compounds 1 and 2, they also emerged as promising antibacterial members with better antibacterial activity. In addition, the results of density functional theory (DFT) showed that compared with compounds 3 and 4, biscoumarins 1 and 2 had lower intramolecular hydrogen bonds (HB) energy in their structures. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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