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2 results on '"Sabbadin, M"'

1. FFPE-Based NGS Approaches into Clinical Practice: The Limits of Glory from a Pathologist Viewpoint

Author

Filippo Cappello, Valentina Angerilli, Giada Munari, Carlotta Ceccon, Marianna Sabbadin, Fabio Pagni, Nicola Fusco, Umberto Malapelle, Matteo Fassan, Cappello, F., Angerilli, V., Munari, G., Ceccon, C., Sabbadin, M., Pagni, F., Fusco, N., Malapelle, U., Fassan, M., Cappello, F, Angerilli, V, Munari, G, Ceccon, C, Sabbadin, M, Pagni, F, Fusco, N, Malapelle, U, and Fassan, M

Subjects
NGS, precision medicine, diagnostics, Medicine (miscellaneous), biomarker, diagnostic, biomarkers
Abstract

The introduction of next-generation sequencing (NGS) in the molecular diagnostic armamentarium is deeply changing pathology practice and laboratory frameworks. NGS allows for the comprehensive molecular characterization of neoplasms, in order to provide the best treatment to oncologic patients. On the other hand, NGS raises technical issues and poses several challenges in terms of education, infrastructures and costs. The aim of this review is to give an overview of the main NGS sequencing platforms that can be used in current molecular diagnostics and gain insights into the clinical applications of NGS in precision oncology. Hence, we also focus on the preanalytical, analytical and interpretative issues raised by the incorporation of NGS in routine pathology diagnostics.

Published
2022

2. miRNAs Involved in Esophageal Carcinogenesis and miRNA-Related Therapeutic Perspectives in Esophageal Carcinoma.

Author

Zarrilli G, Galuppini F, Angerilli V, Munari G, Sabbadin M, Lazzarin V, Nicolè L, Biancotti R, and Fassan M

Subjects
Adenocarcinoma, Biomarkers, Tumor genetics, Biomarkers, Tumor metabolism, Disease Progression, Esophageal Neoplasms metabolism, Esophageal Neoplasms pathology, Esophageal Squamous Cell Carcinoma metabolism, Esophagus pathology, Gene Expression, Gene Expression Profiling, Humans, MicroRNAs metabolism, Precancerous Conditions genetics, Precancerous Conditions metabolism, Precancerous Conditions pathology, Prognosis, Esophageal Neoplasms genetics, MicroRNAs genetics, MicroRNAs therapeutic use
Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that play a pivotal role in many aspects of cell biology, including cancer development. Within esophageal cancer, miRNAs have been proved to be involved in all phases of carcinogenesis, from initiation to metastatic spread. Several miRNAs have been found to be dysregulated in esophageal premalignant lesions, namely Barrett's esophagus, Barrett's dysplasia, and squamous dysplasia. Furthermore, numerous studies have investigated the alteration in the expression levels of many oncomiRNAs and tumor suppressor miRNAs in esophageal squamous cell carcinoma and esophageal adenocarcinoma, thus proving how miRNAs are able modulate crucial regulatory pathways of cancer development. Considering these findings, miRNAs may have a role not only as a diagnostic and prognostic tool, but also as predictive biomarker of response to anti-cancer therapies and as potential therapeutic targets. This review aims to summarize several studies on the matter, focusing on the possible diagnostic-therapeutic implications.

Published
2021
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