1. Immune-Checkpoint Blockade Therapy in Lymphoma
- Author
-
Ayumi Kuzume, SungGi Chi, Nobuhiko Yamauchi, and Yosuke Minami
- Subjects
0301 basic medicine ,Lymphoma ,medicine.medical_treatment ,Programmed Cell Death 1 Receptor ,chemical and pharmacologic phenomena ,Review ,Catalysis ,B7-H1 Antigen ,lcsh:Chemistry ,Inorganic Chemistry ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,medicine ,Cytotoxic T cell ,Humans ,CTLA-4 Antigen ,Physical and Theoretical Chemistry ,Cytotoxicity ,lcsh:QH301-705.5 ,Molecular Biology ,Immune Checkpoint Inhibitors ,Spectroscopy ,business.industry ,Organic Chemistry ,Antibodies, Monoclonal ,General Medicine ,Immunotherapy ,biochemical phenomena, metabolism, and nutrition ,hematologic malignancies ,Ligand (biochemistry) ,medicine.disease ,Immune checkpoint ,Computer Science Applications ,Blockade ,030104 developmental biology ,lcsh:Biology (General) ,lcsh:QD1-999 ,030220 oncology & carcinogenesis ,Cancer research ,bacteria ,programmed cell-death protein 1 (PD-1) ,business - Abstract
Tumor cells use immune-checkpoint pathways to evade the host immune system and suppress immune cell function. These cells express programmed cell-death protein 1 ligand 1 (PD-L1)/PD-L2, which bind to the programmed cell-death protein 1 (PD-1) present on cytotoxic T cells, trigger inhibitory signaling, and reduce cytotoxicity and T-cell exhaustion. Immune-checkpoint blockade can inhibit this signal and may serve as an effective therapeutic strategy in patients with solid tumors. Several trials have been conducted on immune-checkpoint inhibitor therapy in patients with malignant lymphoma and their efficacy has been reported. For example, in Hodgkin lymphoma, immune-checkpoint blockade has resulted in response rates of 65% to 75%. However, in non-Hodgkin lymphoma, the response rate to immune-checkpoint blockade was lower. In this review, we evaluate the biology of immune-checkpoint inhibition and the current data on its efficacy in malignant lymphoma, and identify the cases in which the treatment was more effective.
- Published
- 2020