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Fire risk assessment is a crucial step in effective fire control, playing an important role in reducing fire losses. It has remained a significant topic in the field of fire safety. To explore the research hotspots and frontier trends in fire risk assessment and to understand its macroscopic development trajectory, a sample of 1596 papers from 1976 to 2023, extracted from the Web of Science (WoS) database, was utilized to create a knowledge map. The study employed bibliometric methods, visual analysis, and content analysis to uncover the research pulse and hotspots in the field, offering insights into its future development. The findings indicate that research in fire risk assessment has demonstrated continuous growth over the past 50 years. China and the United States are the dominant research forces in the field, while India and Australia show potential as new drivers for development. Expert groups have formed in this field, with intra-institutional cooperation being the primary focus, while inter-institutional collaboration remains limited. The research outcomes exhibit multidisciplinary crossovers, exerting a significant impact on various disciplinary domains. The research hotspots primarily revolve around investigating fire and explosion accidents, assessing the vulnerability of fire subjects, and identifying potential fire hazards. The application of artificial intelligence technology is identified as a pivotal tool for future development. However, to achieve substantial progress, it is important to enhance the importance accorded to fire risk assessment, foster multinational and cross-institutional cooperation, and prioritize research innovation. [ABSTRACT FROM AUTHOR]

Cydonia Oblonga Mill. is widely distributed in Turkey, Uzbekistan and China and commonly used by the food industry to produce jam, jelly and candies. The aim of this study was to investigate the in vitro antidiabetic activity and anti-diabetic mechanism of Cydonia Oblonga Mill. fruit (COMF). The chemical compositions were further characterized in COMF by UPLC-Q-Orbitrap/MS and 65 components including 22 flavonoids, 16 organic acids, 11 polyphenols, 5 amino acids, 3 pentacyclic triterpenoids and 8 other compounds were identified. The antioxidant activity by DPPH scavenging method and α-glucosidase inhibitory activity were tested. Furthermore, we detected the effects of COMF extract on the proliferation activity of HUVECs, cell viability of HUVECs under H2O2-induced oxidative stress, and NO production. Then, molecular docking activity and α-glucosidase inhibitory activity of seven key flavonoid components selected by bioinformatics analysis and literature in the COMF were studied. Among them, quercetin showed potent inhibitory activity, kaempferol, isorhamnetin, luteolin and apigenin demonstrated moderate inhibitory activity, while rutin and epicatechin exhibited poor inhibitory activity. Subsequently, the effects of quercetin, kaempferol, isorhamnetin, leteolin and apigenin on the gene expression levels of AKT1, IL-6 and VEGFA were verified by real-time fluorescence quantification (RT-qPCR). Molecular biology result showed that different active ingredients can significantly recover the levels of AKT1, IL-6 and VEGFA in HUVECs injured by high glucose. [ABSTRACT FROM AUTHOR]