1. Transcatheter Mitral Repair for Functional Mitral Regurgitation According to Left Ventricular Function: A Real-Life Propensity-Score Matched Study
- Author
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Ignacio J. Amat-Santos, Isaac Pascual, Alberto Berenguer-Jofresa, Eduardo Molina Navarro, Estafanía Fernández Peregrina, Rodrigo Estévez-Loureiro, Víctor Manuel Becerra-Muñoz, Daniel Hernández-Vaquero, Blanca Trejo-Velasco, Ángel Sánchez-Recalde, Jose Alberto de Agustin, Juan F Oteo Dominguez, Valeriano Ruiz-Quevedo, Ana Belen Cid Alvarez, Gabriela Tirado-Conte, Ramiro Trillo-Nouche, Javier Gualis, Rebeca Lorca, Luisa Salido Tahoces, Luis Asmarats Serra, Leire Andraka Ikazuriaga, José R. López-Mínguez, Rosa Ana Hernández-Antolín, Lara Ruiz Gómez, Chi Hion Li, J H Alonso-Briales, Carmen Garrote-Coloma, Fernando Carrasco-Chinchilla, Pilar Jiménez-Quevedo, Jose Luís Diez, Pablo Avanzas, César Morís, Manel Sabaté, Tomás Benito-González, Felipe Fernández-Vázquez, Juan Sanchis, Miguel Romero, Ander Regueiro, Amparo Martinez Monzonís, Xavier Freixa, Maria del Rosario Ortas-Nadal, Cristóbal Urbano-Carrillo, Dabit Arzamendi, Tania Rodriguez-Gabella, Ignacio Cruz-González, J M Hernandez-Garcia, Manuel Pan, Ana María Serrador Frutos, Luis Nombela-Franco, Dolores Mesa, and Xavier Carrillo
- Subjects
medicine.medical_specialty ,lcsh:Medicine ,030204 cardiovascular system & hematology ,Mitraclip ,Article ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,In patient ,030212 general & internal medicine ,cardiovascular diseases ,Functional mitral regurgitation ,Ejection fraction ,Ventricular function ,business.industry ,MitraClip ,lcsh:R ,General Medicine ,transcatheter ,left ventricular ejection Fraction ,Propensity score matching ,Cardiology ,cardiovascular system ,Observational study ,Transcatheter mitral valve repair ,business ,circulatory and respiratory physiology ,functional mitral regurgitation - Abstract
Background: Transcatheter mitral valve repair (TMVR) could improve survival in functional mitral regurgitation (FMR), but it is necessary to consider the influence of left ventricular ejection fraction (LVEF). Therefore, we compare the outcomes after TMVR with Mitraclip®, between two groups according to LVEF. Methods: In an observational registry study, we compared the outcomes in patients with FMR who underwent TMVR with and without LVEF <, 30%. The primary endpoint was the combined one-year all-cause mortality and unplanned hospital readmissions due to HF. The secondary end-points were New York Heart Association (NYHA) functional class and mitral regurgitation (MR) severity. Propensity-score matching was used to create two groups with the same baseline characteristics, except for baseline LVEF. Results: Among 535 FMR eligible patients, 144 patients with LVEF <, 30% (group 1) and 144 with LVEF >, 30% (group 2) had similar propensity scores and were included in the analyses. The primary study endpoint was significantlly higher in group 1 (33.3% vs. 9.4%, p = 0.002). There was a maintained improvement in secondary endpoints without significant differences among groups. Conclusion: FMR patients with LVEF <, 30% treated with MitraClip®, had higher mortality and readmissions than patients with LVEF &ge, 30% treated with the same device. However, both groups improved the NYHA functional class and MR severity.
- Published
- 2020