1. Bibliometric Overview on T-Cell Intracellular Antigens and Their Pathological Implications.
- Author
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Ramos-Velasco, Beatriz, Naranjo, Rocío, and Izquierdo, José M.
- Subjects
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RNA metabolism , *RNA splicing , *RNA-binding proteins , *MOLECULAR pathology , *MOLECULAR biology , *RNA polymerase II , *T cells , *CYTOLOGY - Abstract
Simple Summary: T-cell intracellular antigen 1 (TIA1/TIA-1) and its paralog TIA1-related/like protein (TIAL1/TIAR) have been implicated in the regulation and/or modulation of gene expression through aspects of RNA metabolism, such as (1) transcription, through their interaction with DNA and RNA polymerase II; (2) alternative processing of messenger pre-mRNAs, through selection of canonical and atypical 5′ and 3′ splice sites; (3) localization, stability and/or translation of eukaryotic messenger RNAs, through interaction with 5′ and 3′ untranslatable regions; and (4) control of biological programs fundamental to cell viability (i.e., development, inflammation, proliferation/differentiation, apoptosis, autophagy, responses to stress or viral infections). It is therefore essential to understand the role played by these multifunctional regulators in the establishment and adaptation of the diversity of the transcriptome, translatome, proteome and interactome, which represents a key step in understanding the differences in functional heterogeneity between cells, tissues and organisms with similar genetic complexities. In other words, it is necessary to highlight the importance of identifying the early and late cellular processes and molecular mechanisms where TIA proteins participate and how they contribute to maintain homeostasis, preventing the development and/or progression of deleterious phenotypes. Knowledge of the regulatory dynamics associated with these intracellular antigens will serve as a basis for the identification of future therapeutic strategies. T-cell intracellular antigen 1 (TIA1) and TIA1-like/related protein (TIAL1/TIAR) are two members of the classical family of RNA binding proteins. Through their selective interactions with distinct RNAs and proteins, these multifunctional regulators are involved in chromatin remodeling, RNA splicing and processing and translation regulation, linking them to a wide range of diseases including neuronal disorders, cancer and other pathologies. From their discovery to the present day, many studies have focused on the behavior of these proteins in order to understand their impact on molecular and cellular processes and to understand their relationship to human pathologies. The volume of research on these proteins in various fields, including molecular biology, biochemistry, cell biology, immunology and cancer, has steadily increased, indicating a growing interest in these gene expression regulators among researchers. This information can be used to know the most productive institutions working in the field, understand the focus of research, identify key areas of involvement, delve deeper into their relationship and impact on different diseases, and to establish the level of study associated with them. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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