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Simple Summary: Fascin is an actin-bundling protein that is highly expressed in mature dendritic cells and intratumoral dendritic cells. Dendritic cells are professional antigen-presenting cells of the immune system. Fascin is responsible for regulating dendritic cell migrations and tumor metastasis. The mechanism by which fascin regulates the functions of dendritic cells is currently being explored. In this review, we summarize fascin's involvement in the physiological processes of normal dendritic cells including dendritic cell maturation, migration, and antigen presentation. In cancer patients, there is a subset of dendritic cells with high levels of fascin; activation of this subset of dendritic cells has been shown to enhance antitumor immune response. Fascin inhibitors increase intratumoral dendritic cell accumulation and activation, and cooperate with immune checkpoint inhibitors. Dendritic cells (DCs) are professional antigen-presenting cells that play a crucial role in activating naive T cells through presenting antigen information, thereby influencing immunity and anti-cancer responses. Fascin, a 55-kDa actin-bundling protein, is highly expressed in mature DCs and serves as a marker protein for their identification. However, the precise role of fascin in intratumoral DCs remains poorly understood. In this review, we aim to summarize the role of fascin in both normal and intratumoral DCs. In normal DCs, fascin promotes immune effects through facilitating DC maturation and migration. Through targeting intratumoral DCs, fascin inhibitors enhance anti-tumor immune activity. These roles of fascin in different DC populations offer valuable insights for future research in immunotherapy and strategies aimed at improving cancer treatments. [ABSTRACT FROM AUTHOR]

This study aimed to investigate the association between serum iron (SI) and postoperative delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage (aSAH). We retrospectively analyzed 985 consecutive adult patients diagnosed with aSAH. Demographic, clinical, and laboratory data were recorded. Univariate and multivariate analyses were employed to assess the association between SI and DCI. Propensity-score matching (PSM) analysis was implemented to reduce confounding. Postoperative DCI developed in 14.38% of patients. Lower SI upon admission was detected in aSAH patients with severe clinical conditions and severe aSAH. SI was negatively correlated with WFNS grade (r = −0.3744, p < 0.001) and modified Fisher (mFisher) grade (r = −0.2520, p < 0.001). Multivariable analysis revealed lower SI was independently associated with DCI [odds ratios (OR) 0.281, 95% confidence interval (CI) 0.177–0.448, p < 0.001], while WFNS grade and mFisher grade were not. The receiver-operating characteristics (ROC) curve analysis of SI for DCI gave an area under the curve (AUC) of 0.7 and an optimal cut-off of 7.5 μmol/L (95% CI 0.665 to 0.733, p < 0.0001). PSM demonstrated the DCI group had a significantly lower SI than the non-DCI group (10.91 ± 6.86 vs. 20.34 ± 8.01 μmol/L, p < 0.001). Lower SI remained a significant independent predictor for DCI and an independent poor prognostic factor of aSAH in multivariate analysis (OR 0.363, 95% CI 0.209–0.630, p < 0.001). The predictive performance of SI for poor outcome had a corresponding AUC of 0.718 after PSM. Lower SI upon admission is significantly associated with WFNS grade, mFisher grade, and predicts postoperative DCI and poor outcome at 90 days following aSAH. [ABSTRACT FROM AUTHOR]

The correct sentence should be: The matched DCI group had a significantly lower SI level than the matched non-DCI group (9.00 ± 6.29 vs. 20.13 ± 8.45 mol/L, I p i < 0.001) (Table 1 and Figure 2D). Admission Serum Iron as an Independent Risk Factor for Postoperative Delayed Cerebral Ischemia Following Aneurysmal Subarachnoid Hemorrhage: A Propensity-Matched Analysis. In Table 1, the number of patients from admission to surgical treatment (<=72 h) in the Non-DCI group was 77 after PSM. [Extracted from the article]