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This study aimed to investigate the effect of the transverse sinus (TS) stenosis (TSS) position caused by arachnoid granulation on patients with venous pulsatile tinnitus (VPT) and to further identify the types of TSS that are of therapeutic significance for patients. Multiphysics interaction models of six patients with moderate TSS caused by arachnoid granulation and virtual stent placement in TSS were reconstructed, including three patients with TSS located in the middle segment of the TS (group 1) and three patients with TTS in the middle and proximal involvement segment of the TS (group 2). The transient multiphysics interaction simulation method was applied to elucidate the differences in biomechanical and acoustic parameters between the two groups. The results revealed that the blood flow pattern at the TS and sigmoid sinus junction was significantly changed depending on the stenosis position. Preoperative patients had increased blood flow in the TSS region and TSS downstream where the blood flow impacted the vessel wall. In group 1, the postoperative blood flow pattern, average wall pressure, vessel wall vibration, and sound pressure level of the three patients were comparable to the preoperative state. However, the postoperative blood flow velocity decreased in group 2. The postoperative average wall pressure, vessel wall vibration, and sound pressure level of the three patients were significantly improved compared with the preoperative state. Intravascular intervention therapy should be considered for patients with moderate TSS caused by arachnoid granulations in the middle and proximal involvement segment of the TS. TSS might not be considered the cause of VPT symptoms in patients with moderate TSS caused by arachnoid granulation in the middle segment of the TS. [ABSTRACT FROM AUTHOR]

Sigmoid sinus wall dehiscence (SSWD) is an important etiology of venous pulsatile tinnitus (VPT) and is treated by sigmoid sinus wall reconstruction (SSWR). This study aimed to investigate the therapeutic effects of the different degrees of SSWR and the prognostic effect in patients with VPT. Personalized models of three patients with SSWD (control), 3/4SSWD, 1/2SSWD, 1/4SSWD, and 0SSWD were reconstructed. A multiphysics interaction approach was applied to elucidate the biomechanical and acoustic changes. Results revealed that after SSWR, the average pressure of venous vessel on the SSWD region reduced by 33.70 ± 12.53%, 35.86 ± 12.39%, and 39.70 ± 12.45% (mean ± SD) in three patients with 3/4SSWD, 1/2SSWD, and 1/4SSWD. The maximum displacement of the SSWR region reduced by 25.91 ± 30.20%, 37.20 ± 31.47%, 52.60 ± 34.66%, and 79.35 ± 18.13% (mean ± SD) in three patients with 3/4SSWD, 1/2SSWD, 1/4SSWD, and 0SSWD, with a magnitude approximately 10−3 times that of the venous vessel in the SSWD region. The sound pressure level at the tympanum reduced by 23.72 ± 1.91%, 31.03 ± 14.40%, 45.62 ± 19.11%, and 128.46 ± 15.46% (mean ± SD). The SSWR region was still loaded with high stress in comparison to the surrounding region. The SSWR region of the temporal bone effectively shielded the high wall pressure and blocked the transmission of venous vessel vibration to the inner ear. Patients with inadequate SSWR still had residual VPT symptoms despite the remission of VPT symptoms. Complete SSWR could completely solve VPT issues. High-stress distribution of the SSWR region may be the cause of the recurrence of VPT symptoms. [ABSTRACT FROM AUTHOR]

This study aimed to investigate the topological characteristics of the resting-state functional network and the underlying pathological mechanism in nondialysis patients with stage 5 chronic kidney disease (CKD5 ND). Eighty-five subjects (21 patients with CKD5 ND, 32 patients with CKD on maintenance hemodialysis (HD), and 32 healthy controls (HCs)) underwent laboratory examinations, neuropsychological tests, and brain magnetic resonance imaging. The topological characteristics of networks were compared with a graph–theoretical approach, and correlations between neuropsychological scores and network properties were analyzed. All participants exhibited networks with small-world attributes, and global topological attributes were impaired in both groups of patients with CKD 5 (ND and HD) compared with HCs (p < 0.05); these impairments were more severe in the CKD5 ND group than in the HD group (p < 0.05). Compared with the HC group, the degree centrality of the CKD5 ND group decreased mainly in the basal ganglia and increased in the bilateral orbitofrontal gyrus, bilateral precuneus, and right cuneus. Correlation analysis showed that the degree of small-worldness, normalized clustering coefficients, and Montreal Cognitive Assessment (MoCA) scores were positively correlated and that characteristic path length was negatively correlated with these variables in patients with CKD5 ND. The nodal efficiency of the bilateral putamen (r = 0.53, p < 0.001 and r = 0.47, p < 0.001), left thalamus (r = 0.37, p < 0.001), and right caudate nucleus (r = 0.28, p = 0.01) was positively correlated with MoCA scores. In conclusion, all CKD5 ND patients exhibited changes in functional network topological properties and were closely associated with mild cognitive impairment. More interestingly, the topological property changes in CKD5 ND patients were dominated by basal ganglia areas, which may be more helpful to understand and possibly reveal the underlying pathological mechanisms of cognitive impairment in CKD5 ND. [ABSTRACT FROM AUTHOR]

A two-year field experiment was executed to investigate the impact of different controlled irrigation and drainage regimes on the morphological and mechanical traits related to the lodging resistance of rice in Jiangsu province, China. Three irrigation regimes were comprised of conventional flooding practices (CK), controlled irrigation and drainage mode I (CID-1), and controlled irrigation and drainage mode II (CID-2). Results indicated that there was no significant difference in the heights of rice plants under the three irrigation regimes, but the average diameter of CK treatment was 21% higher than that of CID-2 in the 2013 season. Similarly, the value of the section modulus of CK was significantly higher than that of CID-2 (p < 0.05). On the contrary, the length of basal internodes of CK and CID-1 was significantly lower than that of CID-2 in 2013 (p < 0.05). For both seasons, the safety factor against stem breakage (SFs) of CID-2 always had the lowest value under different irrigation regimes, which might be related to the significantly lower values of bending strength of culm at breaking (S) and the bending stress (BS) as well as lower ash content and cellulose content in CID-2 compared with CK and CID-1. Collectively, properly increasing the depth of water levels after heavy rain under the current water-saving mode (CID-1) would not increase the risk of lodging for rice plants, whereas if the water depth after heavy rain was kept higher than 20 cm (CID-2), the SFs would be significantly lower than that of CK, and the rice plants would be much more likely to undergo lodging. [ABSTRACT FROM AUTHOR]

The application of voxel-mirrored homotopic connectivity (VMHC) analysis to study the central mechanism of migraine has been limited. Furthermore, little is known about inter-hemispheric functional connectivity (FC) alterations during resting state in female patients with migraine. This study aimed to investigate potential interictal VMHC impairments in migraine without aura (MwoA) patients and the relationship between connectivity alterations and clinical parameters. Resting-state functional magnetic resonance imaging data and clinical information were acquired from 43 female MwoA patients and 43 matched healthy controls. VMHC analysis was used to compare differences between these two groups, and brain regions showing significant differences were chosen as a mask to perform a seed-based FC group comparison. Subsequent correlation analysis was conducted to explore the relationship between abnormal inter-hemispheric FC and clinical data. Compared with healthy controls, female MwoA patients revealed significantly decreased VMHC in the bilateral cerebellum; cuneus; and lingual, middle occipital, precentral and postcentral gyri. Seed-based FC analysis indicated disrupted intrinsic connectivity in the cerebellum, and default mode, visual and sensorimotor network. These VMHC and FC abnormalities were negatively correlated with clinical indexes including duration of disease, migraine days and visual analogue scale. These inter-hemispheric FC impairments and correlations between abnormal VMHC and FC and clinical scores may improve our understanding of the central mechanism of female-specific migraine. [ABSTRACT FROM AUTHOR]

Aquaculture wastewater contains considerable quantities of organic matter, nitrogen, and phosphorus. Irrigation of paddy rice with aquaculture wastewater can make full use of water and fertilizer, which has practical significance for alleviating water-use conflicts in the coastal areas of Jiangsu Province and promoting soil desalinization. Our objective in this study was to evaluate the effects of water quality indexes of surface discharge in paddy fields, total nitrogen (TN) and total phosphorus (TP) losses of discharge in paddy fields, growing indexes of plants, grain yield, as well as soil salinity affected by the different irrigation treatments. To achieve this objective, experiments were conducted from May to October in 2017. There were four treatment combinations: I1W1 (shallow–frequent irrigation and aquaculture wastewater), I2W1 (shallow–wet irrigation and aquaculture wastewater), I3W1 (flooding irrigation and aquaculture wastewater), and I1W2 (shallow–frequent irrigation and fresh water). The results revealed that there was no significant difference in grain yield among the three wastewater irrigation treatments. Meanwhile, the values of water quality indexes were optimal in I3W1; the total losses of TN and TP of the I3W1 treatment were the lowest over the three important growth stages; the desalinization rate of I3W1 was the largest due to its long hydraulic retention time and large irrigation depth. The overall results suggested that the I3W1 treatment was the optimal treatment. [ABSTRACT FROM AUTHOR]

Understanding the effects of irrigation regime and soil texture on potassium-use efficiency (KUE) of rice (Oryza sativa. L) is essential for improving rice productivity. In this regard, experiments were conducted from July to October in 2016 and 2017 by using a randomized complete block design in a factorial arrangement with four replications. The rice plants were grown in three soils, with clay contents of 40%, 50%, and 60%, which were marked as S (40%), S (50%), and S (60%), respectively. For each soil type, irrigation regimes, namely, R (F, S100%), R (F, S90%), and R (F, S70%), were established by setting the lower limit of irrigation to 100%, 90%, and 70% of saturated soil water content, respectively, and the upper limit of irrigation with 30 mm of flooding water above the soil surface for all irrigation regimes. Results showed that the responses of the roots and shoots and the potassium accumulation (KA) and KUE of rice were significantly affected by the water regime and soil texture. In the same irrigation regime, increasing the soil clay content improved the K utilization of rice. Under the same soil type, R (F, S100%) was the optimal water management practice for growing rice. The R (F, S100%) S (60%) treatment presented the highest KUE, which was 56.4% in 2016 and 68.1% in 2017. The R (F, S70%) S (40%) treatment showed the lowest KUE, which was 13.8% in 2016 and 14.9% in 2017. These results enrich knowledge regarding the relationship among soil, water, and rice, and provide valuable insights on the effect of irrigation regime and soil texture on the KA and KUE of rice. [ABSTRACT FROM AUTHOR]

In the middle and lower reaches of the Yangtze River, the rainfall is greater in summer. The technology of rain catching and controlled irrigation of rice help to save water by raising the water depth of the field after rain while the soil water content during the rest period is maintained at 70–100% of field capacity. The objectives of this study were to evaluate rice growth, canopy light utilization, and yield of rice under different rain-catching and controlled irrigation modes (T1: light drought and low storage, T2: light drought and high storage), and to find the optimal storage depth after rain for rice. Measurements included the rice plant height, tiller number, high tiller growth, leaf angle, canopy interception rate, and yield shape. The plot experiment was conducted in 2012 and 2013 using Nanjing 44 (Oryza sativa L.) as the test material. The results showed that T1 treatment improved the height of rice plants and the number of effective tillers in the late growth stage. The number of high tillers had a great influence on the total leaf dry quality; compared with conventional irrigation (CK), the number of high tillers increased by 11.36% and 7.87% in T1 and T2, respectively; the canopy interception rate of T1 above 0 cm was higher than that in T2 and CK; and the leaf area index (LAI) was closely related to the 0–40 cm of canopy light distribution. The number of grains per panicle in T1 was lower than in CK and T2; however, the number of grains in T1 was less, and the 1000 grain weight was higher. On the 63 days and 83 days after transplanting in 2012 and 78 days after transplanting in 2013, the first, second, and third leaf angles of T1 were larger. Rain-catching and controlled irrigation can increase the dry weight and shoot dry weight of rice, and light drought and low storage (T1) conditions are good for maintaining a high yield because of more tiller number, more grains per panicle and reasonable light distribution. [ABSTRACT FROM AUTHOR]