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It is important to differentiate milk with different thermostabilities for diverse applications in food products and for the appropriate selection of processing and maintenance of manufacturing facilities. In this review, an overview of the chemical changes in milk subjected to high-temperature heating is given. An emphasis is given to the studies of traditional and state-of-the-art strategies for assessing the milk thermostability, as well as their influencing factors. Traditional subjective and objective techniques have been used extensively in many studies for evaluating thermostability, whereas recent research has been focused on novel approaches with greater objectivity and accuracy, including innovative physical, spectroscopic, and predictive tools. [ABSTRACT FROM AUTHOR]

Rubidium atomic clocks have been used extensively in various fields, with applications such as a core component of Global Navigation Satellite Systems (GNSS). However, they exhibit inherently poor long-term stability. This paper presents the development of a control system for rubidium atomic clocks. It introduces an adaptive Kalman filtering algorithm for the disciplining of a rubidium atomic clock, utilizing autocovariance least squares (ALS) to estimate the clock's noise parameters. The experimental results demonstrate that the proposed algorithm achieves a high estimation accuracy. The standard deviation of the clock error between the steered rubidium atomic clock 1 Pulse Per Second (1PPS) and Coordinated Universal Time (UTC) provided by the National Time Service Center (NTSC) is better than 2.568 nanoseconds(ns), with peak-to-peak values improving to within 11.358 ns. Notably, its frequency stability is reduced to 3.06 × 10−13 @100,000 s. The results for the rubidium atomic clock demonstrate that the adaptive Kalman filtering algorithm proposed herein constitutes an accurate and effective control strategy for the rubidium atomic clock discipline. [ABSTRACT FROM AUTHOR]

In the task of human behavior detection, video classification based on deep learning has become a prevalent technique. The existing models are limited due to an inadequate understanding of behavior characteristics, which restricts their ability to achieve more accurate recognition results. To address this issue, this paper proposes a new model, which is an improvement upon the existing PPTSM model. Specifically, our model employs a multi-scale dilated attention mechanism, which enables the model to integrate multi-scale semantic information and capture characteristic information of abnormal human behavior more effectively. Additionally, to enhance the characteristic information of human behavior, we propose a gradient flow feature information fusion module that integrates high-level semantic features with low-level detail features, enabling the network to extract more comprehensive features. Experiments conducted on an elevator passenger dataset containing four abnormal behaviors (door picking, jumping, kicking, and door blocking) show that the top-1 Acc of our model is improved by 10% compared to the PPTSM model, reaching 95%. Moreover, experiments with four publicly available datasets(UCF24, UCF101, HMDB51, and the Something-Something-v1 dataset) demonstrate that our method achieves results superior to PPTSM by 6.8%, 6.1%, 21.2%, and 3.96%, respectively. [ABSTRACT FROM AUTHOR]

A series of ZnO-doped nitrogen-carbon materials (xZnO-N-C) with ZnO contents of 5–40% are prepared by a vacuum curing–carbonization strategy using polyamide-imide as the N-C source and zinc nitrate as the metal source for propane dehydrogenation (PDH). 20ZnO-N-C exhibits outstanding initial activity (propane conversion of 35.2% and propene yield of 24.6%) and a relatively low deactivation rate (0.071 h−1) at 600 °C. The results of detailed characterization show that small ZnO nanoparticles (5.5 nm) with high dispersion on the catalyst can be obtained by adjusting the ZnO loading. Moreover, more nitrogen-based species, especially ZnNx species, are formed on 20ZnO-N-C in comparison with 20ZnO-N-C-air prepared via curing carbonization without vacuum, which may contribute to the higher product selectivity and catalytic stability of 20ZnO-N-C. The active sites for the PDH reaction on the catalyst system are proposed to be C=O species and Zn2+ species. Moreover, the carbon deposition and the aggregation of ZnO nanoparticles are the causes of activity loss on this catalyst system. [ABSTRACT FROM AUTHOR]

In this work, a flexible electrochemical sensor was developed for the detection of organophosphorus pesticides (OPs). To fabricate the sensor, graphene was generated in situ by laser-induced graphene (LIG) technology on a flexible substrate of polyimide (PI) film to form a three-electrode array, and pralidoxime (PAM) chloride was used as the probe molecule. CeO2 was used to modify the working electrode to improve the sensitivity of the sensor because of its electrocatalytic effect on the oxidation of PAM, and the Ag/AgCl reference electrode was prepared by the drop coating method. The effects of the laser power, laser scanning speed, and CeO2 modification on the electrochemical properties of the sensor were studied in detail. The results prove that the sensor has good repeatability, stability, and anti-interference ability, and it shows an excellent linear response in the chlorpyrifos concentration range from 1.4 × 10−8 M to 1.12 × 10−7 M with the detection limit of 7.01 × 10−10 M. [ABSTRACT FROM AUTHOR]

The spill pressure of the contaminant source is an important factor affecting the amount, location, form, and behavior of the dense non-aqueous phase liquids (DNAPLs) that plume in a contaminated subsurface environment. In this study, perchloroethylene (PCE) infiltration, distribution and, remediation via a surfactant-enhanced aquifer remediation (SEAR) technique for a PCE spill event are simulated to evaluate the effects of the spill pressure of the contaminant source on the DNAPLs' behavior in two-dimensional homogeneous and heterogeneous aquifers. Five scenarios with different spill pressures of contamination sources are considered to perform the simulations. The results indicate that the spill pressure of the contaminant source has an obvious influence on the distribution of DNAPLs and the associated efficiency of remediation in homogeneous and heterogeneous aquifers. As the spill pressure increases, more and more contaminants come into the aquifer and the spread range of contamination becomes wider and wider. Simultaneously, the remediation efficiency of contamination also decreases from 93.49% to 65.90% as the spill pressure increases from 33.0 kPa to 41.0 kPa for a heterogeneous aquifer with 200 realizations. The simulation results in both homogeneous and heterogeneous aquifers show the same influence of the spill pressure of the contaminant source on PCE behaviors in the two-dimensional model. This study indicates that the consideration of the spill pressure of the contaminant sources (such as underground petrol tanks, underground oil storage, underground pipeline, and landfill leakage) is essential for the disposal of contaminant leakage in the subsurface environment. Otherwise, it is impossible to accurately predict the migration and distribution of DNAPLs and determine the efficient scheme for the removal of contaminant spills in groundwater systems. [ABSTRACT FROM AUTHOR]

Aiming at the problems of low machining accuracy and more serious tool wear in the traditional diamond grinding machining (DGM) microstructure of hard and brittle materials, this paper proposes high-speed rotary ultrasonic machining (HRUM) technology and develops a HRUM machine tool. The hardware part of the machine tool mainly includes the spindle module, micro-motion system module, ultrasonic machining tank module, and data acquisition (DAQ) system module. The LabView-based controlled machining control system, including motion selection, initialization, coarse tool setting, constant force tool setting, control machining, and coordinate display module, is developed. Comparative experimental research of the HRUM and DGM of small holes in Al2O3 ceramics is carried out in the developed HRUM machine tool. The results demonstrate that HRUM effectively reduces axial cutting forces, reduces binder adhesion, and suppresses slippage while improving tool-cutting ability and extending tool life compared to DGM under the same machining parameters. This technology has essential research significance for the high-precision and efficient machining of microstructures in hard and brittle materials. [ABSTRACT FROM AUTHOR]

In view of the importance of neck strength training and the lack of adequate training equipment, this study designed a new oscillating hydraulic trainer (OHT) of neck based on oscillating hydraulic damper. We used surface electromyography (sEMG) and subjective ratings to evaluate the neck OHT and compared the results with a simple hat trainer (HATT) and traditional weight trainer (TWT) to verify the feasibility and validity of the OHT. Under similar exercise conditions, 12 subjects performed a set of neck flexion and extension exercise with these 3 trainers. The sEMG signals of targeted muscles were collected in real time, and subjects were asked to complete subjective evaluations of product usability after exercise. The results showed that the root mean square (RMS%) of sEMG indicated that the OHT could provide two-way resistance and train the flexors and extensors simultaneously. The overall degree of muscle activation with OHT was higher than that with the other two trainers in one movement cycle. In terms of resistance characteristics exhibited by the sEMG waveform, duration (D) with OHT was significantly longer than HATT and TWT when exercising at a high speed, while Peak Timing (PT) was later. The ratings of product usability and performing usability of OHT were remarkably higher than that of HATT and TWT. Based on the above results, the OHT was proved to be more suitable for strength training, such as neck muscles, which were getting more attention gradually, but lacked mature and special training equipment. [ABSTRACT FROM AUTHOR]

Background: We designed an exercise system in which the user is accompanied by a virtual partner (VP) and tested bodyweight squat performance with different interactive VP features to explore the comprehensive impact of these VP features on the individual's exercise level (EL) and exercise perception. Methods: This experiment used three interactive features of VP, including body movement (BM), eye gaze (EG), and sports performance (SP), as independent variables, and the exercise level (EL), subjective exercise enjoyment, attitude toward the team formed with the VP, and local muscle fatigue degree of the exerciser as observational indicators. We designed a 2 (with or without VP's BM) × 2 (with or without VP's EG) × 2 (with or without VP's SP) within-participants factorial experiment. A total of 40 college students were invited to complete 320 groups of experiments. Results: (1) Regarding EL, the main effects of BM and SP were significant (p < 0.001). The pairwise interaction effects of the three independent variables on EL were all significant (p < 0.05). (2) Regarding exercise perception, the main effects of BM (p < 0.001) and EG (p < 0.001) on subjective exercise enjoyment were significant. The main effect of BM on the attitude toward the sports team formed with the VP was significant (p < 0.001). The interaction effect of BM and SP on the attitude toward the sports team formed with the VP was significant (p < 0.001). (3) Regarding the degree of local muscle fatigue, the main effects of BM, EG, and SP and their interaction effects were not significant (p > 0.05). Conclusion: BM and EG from the VP elevate EL and exercise perception during squat exercises, while the VP with SP inhibited the EL and harmed exercise perception. The conclusions of this study can provide references to guide the interactive design of VP-accompanied exercise systems. [ABSTRACT FROM AUTHOR]

In this experiment, we investigated the effects of different reactions on the growth process and morphology of h-MoO3 and α-MoO3, and their optical properties and photocatalytic activities were also investigated. Orthogonal experiments were designed to investigate the effects of four influencing factors, namely the amount of ammonium molybdate tetrahydrate (AHM), the type of acid, the reaction temperature and the holding time, on the morphology of h-MoO3 by a microwave hydrothermal method. The phase and morphology were analyzed by using advanced physicochemical techniques. The XRD results showed that the samples produced by the microwave hydrothermal method had sharp diffraction peaks, high crystallinity and complete crystalline shape. AHM generates h-MoO3 in both hydrochloric and nitric acid environments. In particular, when the temperature rises to 200 °C, the generated h-MoO3 will be converted to α-MoO3 in a nitric acid environment, which will be generated in a sulfuric acid environment. Therefore, increasing the reaction temperature will result in the conversion of h-MoO3 to α-MoO3 in sulfuric acid solution. SEM results show that the sample prepared from hydrochloric acid solution has a complete hexagonal prism morphology, while the sample prepared from sulfuric acid solution presents a long fibrous morphology, and the sample prepared from nitric acid solution has many defects on the surface of the hexagonal prism morphology. Interestingly, sample A11 prepared in nitric acid solution showed a spherical structure. Since the generated A3, A6 and A9 samples are all stable phase α-MoO3, they have a wider band gap compared with other samples. Their particle size is up to the nanometer scale, so they have strong adsorption properties. The spherical sample A11 has excellent adsorption and photocatalytic activity. [ABSTRACT FROM AUTHOR]

Polyamide (PA) and bisphenol A (BPA) are selected as typical microplastic and endocrine-disrupting chemicals in this study. The adsorption of BPA on the surface of PA and the effect of PA on the transport behavior of BPA in groundwater are systematically investigated using a combination of batch experiments, column experiments and numerical models. The results of scanning electron microscope (SEM) and Fourier transform infrared spectra (FTIR) show that the surface of PA particles is changed significantly after adsorption of BPA. The isothermal adsorption process of BPA can be simulated by the Langmuir model and the Freundlich model. Kinetic adsorption, on the other hand, can be fitted by a quasi-first-order adsorption model, and the adsorption results indicate that the maximum adsorption of BPA on PA reaches 13 mg·g−1. The results of the column experiments suggest that the mass recovery rate of BPA decreases with PA content, and increases with flow velocity, while initial concentration has no apparent influence on BPA transport. In addition, due to the hydrolysis of BPA, the mass recovery rate of BPA does not change with pH under conditions of pH < 10.2 and increases substantially to 94% when pH > 10.2. Moreover, Ca2+ has a significant inhibitory effect on the transport of BPA, while Na+ has no apparent influence on the transport of BPA. The transport process of BPA in porous media is simulated using a single-point kinetic model, and the fitted mathematical relationships for the variation of kinetic parameters with environmental factors are obtained by regression analysis. [ABSTRACT FROM AUTHOR]

One advantage of a resistive sensor array (RSA) with shared rows (M) and shared columns (N) is the reduced number of wires from M × N + 1 to M + N which can greatly lessen the complexity and burden on wearable electronic systems. However, the drawback is the crosstalk current effect between adjacent elements, which will lead to high measurement error. Although several solutions have been reported, they mainly focus on RSAs with high resistance (≥100 Ω). There is a lack of research that addresses RSAs with resistor values below 100 Ω. Here, we introduce a new circuit design named the dynamic zero current method (DZCM) to further decrease the measurement error. From the low value RSA test with ideal resistors, the DZCM exhibits lower error than the zero potential method (ZPM). In the case of the error variation ratio of amplifier offset voltage, the DZCM has a 4%/mV (row) to 7%/mV (column) ratio, while the ZPM has an almost 25%/mV (row) to 45%/mV (column) ratio and it increases with array size. [ABSTRACT FROM AUTHOR]

The effect of graphene (GN) on the transport of CIP and NOR in porous media is investigated by a combination of batch experiments, column experiments and mathematical models. The results obtained by batch experiments show that GN has great adsorption capacity to two antibiotic contaminants, and the maximum adsorption amounts based on the Langmuir model calculation are 270.67 mg/g and 178.36 mg/g, respectively. The column experiments suggest the mobility of CIP and NOR decreases with the mass fraction of GN packed in porous media, and the mass recovery rates of CIP and NOR increase with flow velocity. As the concentration of Na+ increases, the mobility of CIP and NOR is enhanced. However, Ca2+ has a significant enhancement effect on the mobility of CIP and NOR. Moreover, the transport processes of CIP and NOR in the column are predicted by a BDST mathematical model, and the calculated results are in good agreement with the experimental results. The relationships between kinetic parameters related to QNs' mobility and GN content, flow velocity and ionic strength are obtained by a regression analysis, which can be used to predict the mobility of CIP and NOR in porous media. [ABSTRACT FROM AUTHOR]

With advances in information and communication technology and the rapid development of the mobile Internet, mobile health (m-health) management applications (apps) play a key role in modern health assistance programs. However, m-health management apps still face major dilemmas in ensuring user satisfaction and continuous use. Based on resolving the contradiction between the multiple complex and ambiguous demands of users and the limited development resources of companies, this study explores ways to improve user satisfaction and the willingness to sustain m-health management app usage to build efficient and clear m-health management app demand insights and development strategies. This study integrates the advantages of the Kano model and the decision-making trial and evaluation laboratory (DEMATEL) method. From the systematic level, an attribute acquisition-classification-key attribute extraction and influence relationship quantification-hierarchy analytic hierarchy model was built. The research results provide implications for further improvement efforts to consider not only technological capabilities but also effective insights into the attributes that are highly expected by users, thus improving the accuracy of app function positioning and, in turn, enhancing user satisfaction and continuous usage intention. Additionally, the results provide decision-makers in enterprises and relevant research and development (R&D) departments with clear and efficient app requirement relationships and development strategies. [ABSTRACT FROM AUTHOR]

A dicompartmental Schiff base ligand was synthesized and used for the assembly of a lanthanide grid-like complex. Dinuclear Dy2 and tetranuclear Dy4 complexes were isolated from the reaction of the ligand with different dysprosium salt. Single crystal X-ray diffractions show that the two DyIII ions in Dy2 are adopted in the N3O coordination pockets of the ligand and further coordinated by water molecules, whereas, for Dy4, the four DyIII ions are clamped by four ligands through their terminal N3O coordination pockets, forming a grid-type assembly. Magnetic studies reveal that complex Dy2 shows field-induced single-molecule magnetic behavior under 1000 Oe dc field, complex Dy4 shows fast relaxation under zero field and field-induced single-molecule magnet (SMM) behavior under 500 Oe. The difference in the magnetic relaxation is related to the various deprotonation of the ligand and distinct topology of the assemblies. [ABSTRACT FROM AUTHOR]

Simple Summary: Colon cancer is a common malignant tumor that occurs in the digestive tract of the colon. At present, the treatment of colon cancer is unsatisfactory, and its recurrence and drug resistance are common. It is important to find an effective treatment for colon cancer. In this study, we found that coxsackievirus group B3 can induce pyroptosis in colon cancer cell lines, which shows its oncolytic activity. Based on these findings, we believe that CVB3 may play an important role in the treatment of colon cancer as an oncolytic virus. Colon cancer is the second leading cause of cancer-related death, and there are few effective therapies for colon cancer. This study explored the use of coxsackievirus group B3 (CVB3) as an oncolytic virus for the treatment of colon cancer. In this study, we verified that CVB3 induces death of colon cancer cell lines by directly observing cell morphology and Western blot results, and observed the oncolytic effects of CVB3 by constructing an immunodeficient nude mice model. Our data show that CVB3 induces pyroptosis in colon cancer cell lines. Mechanistically, we demonstrated that CVB3 causes cleavage of gasdermin E (GSDME), but not gasdermin D (GSDMD), by activating caspase-3. This leads to production of GSDME N-termini and the development of pores in the plasma membrane, inducing pyroptosis of colon cancer cell lines. We also demonstrate that CVB3-induced pyroptosis is promoted by reactive oxygen species (ROS). Finally, in vivo studies using immunodeficient nude mice revealed that intratumoral injection of CVB3 led to significant tumor regression. Our findings indicate that CVB3 has oncolytic activity in colon cancer cell lines via GSDME-mediated pyroptosis. [ABSTRACT FROM AUTHOR]

At present, there are few articles about the timekeeping performance of domestic atomic clocks in their moving state. In this paper, the frequency stability changes of hydrogen atomic and cesium atomic clocks in stationary and moving states are compared and analyzed; the frequency stability of the atomic clock at the beginning of its transition from moving state to stationary state is tested and analyzed; the influence of three main noises of atomic clocks on frequency stability is analyzed; and finally, the difference in the predictability of atomic clocks in moving and stationary states is analyzed. The results show that: (1) in the moving state, the frequency stability of a hydrogen clock decreases by 1–2 orders of magnitude, and the frequency stability of a cesium clock decreases by 0.5 orders of magnitude; (2) in the recovery stage, the frequency stability of hydrogen and cesium clocks is between that in static and moving stages, but the frequency stability fluctuates greatly in this stage; (3) in the moving state, the three main noises of the atomic clock all increase, of which the increase in the white noise of phase modulation is the largest, indicating that it is the most sensitive to vibration and has the greatest impact on the frequency stability of the atomic clock during the moving period; (4) in the mobile state, the RMS of the prediction data of the hydrogen clock and cesium clock greatly increases compared with that in the static state. [ABSTRACT FROM AUTHOR]

Multilayer graphene (MLG) prepared via ultrasonic exfoliation has many advantages such as its low-cost and defect-free nature, high electronic conductivity, and large specific surface area, which make it an apt conductive substrate for TiO2 composites. To synthesize graphene/TiO2 hybrids, traditional methods that greatly depend on the chemical bond of oxygen-containing functional groups on graphene with titanium cations are not applicable due to the absence of these functional groups on MLG. In this work, a facile chemical method is developed to directly deposit TiO2 on the MLG surface without the introduction of chemically active groups. With this method, four types of TiO2 materials, that is pure anatase TiO2 nanoparticles, a mixture of anatase TiO2 nanoparticles and rutile TiO2 nanoflowers, pure rutile TiO2 nanoflowers, and pure rutile TiO2 nanorods, are homogeneously anchored on the MLG surface by controlling the amount of HCl in the reactant. Interestingly, the rutile TiO2 nanorods in the TiO2/MLG composite are assembled by many TiO2 nanowires with an ultra-small diameter and ultra-long length, which provides a better synergetic effect for high performances as LIB anodes than other composites. A specific capacity of 631.4 mAh g−1 after 100 cycles at a current density of 100 mA g−1 is delivered, indicating it to be a valuable LIB anode material with low cost and high electrochemical performances. [ABSTRACT FROM AUTHOR]

In the context of the global Sustainable Development Goals, the study of tourism eco-efficiency (TE) becomes particularly important for the balance between environmental protection and economic development in tourist destinations. This paper improves the measurement method of tourism carbon emissions, uses the Super-SBM model of undesired output to measure China's TE, and then explores the impact of new urbanization (NU) on TE. The results show that TE in China is in dynamic equilibrium in general, the agglomeration characteristics of efficiency changed from high in the east and low in the west to low in the south and high in the north, and developmental differences first increased and then decreased. NU development has a significant one-way positive impact on TE at the national level and in the eastern region. As far as impact, economic urbanization plays a great role, and ecological factors become more and more important. NU has a rapid and long-term impact on TE, and its contribution rate to developed economic regions can reach 35%. This study will provide an important reference for sustainable development of tourism under the trend of urbanization. [ABSTRACT FROM AUTHOR]

The Kleier model and Carrier-mediated theory are effective for molecularly designing pesticides with phloem mobility. However, the single Kleier model or Carrier-mediated theory cannot achieve a reliable explanation of the phloem mobility of all exogenous substances. A detailed investigation of the two models and the scope of their applications can provide a more accurate and highly efficient basis for the guidance of the design and development of phloem-mobile pesticides. In the present paper, a strategy using active ingredient-amino acid conjugates as mode compounds is developed based on Carrier-mediated theory. An N-alkylated amino acid is used to improve the pesticide's physicochemical properties following the Kleier model, thus allowing the conjugates to fall on the predicted and more accessible transportation region of phloem. Moreover, the influence of this movement on phloem is inspected by the Kleier model and Carrier-mediated theory. To verify this strategy, a series of N-alkylated phenazine-1-carboxylic acid-glycine compounds (PCA-Gly) were designed and synthesized. The results related to the castor bean seeds (R. communis L.) indicated that all the target compounds (4a–4f) had phloem mobility. The capacity for phloem mobility shows that N-alkylated glycine containing small substituents can significantly improve PCA phloem mobility, such as 4c(i-C3H7-N) > 4a(CH3-N) ≈ 4b(C2H5-N) > 4d (t-C4H9-N) > PCA-Gly > 4e(C6H5-N) > 4f(CH2COOH-N), with an oil–water partition coefficient between 1.2~2.5. In particular, compounds 4a(CH3-N), 4b(C2H5-N), and 4c(i-C3H7-N) present better phloem mobility, with the average concentrations in phloem sap of 14.62 μΜ, 13.98 μΜ, and 17.63 μΜ in the first 5 h, which are 8 to 10 times higher than PCA-Gly (1.71 μΜ). The results reveal that the Kleier model and Carrier-mediated theory play a guiding role in the design of phloem-mobile pesticides. However, the single Kleier model or Carrier-mediated theory are not entirely accurate. Still, there is a synergism between Carrier-mediated theory and the Kleier model for promoting the phloem transport of exogenous compounds. Therefore, we suggest the introduction of endogenous plant compounds as a promoiety to improve the phloem mobility of pesticides through Carrier-mediated theory. It is necessary to consider the improvement of physicochemical properties according to the Kleier model, which can contribute to a scientific theory for developing phloem-mobile pesticides. [ABSTRACT FROM AUTHOR]

Simple Summary: Viral mutations at the preS region of hepatitis B virus (HBV) significantly increase the risk of developing hepatocellular carcinoma (HCC). Compared to HBV preS deletion, the oncogenic effect of preS combo mutation has rarely been investigated. With a cohort including 2114 subjects, we demonstrated that preS combo mutations G2950A/G2951A/A2962G/C2964A and C3116T/T31C significantly increased the risk of HCC in patients without antiviral treatment, whereas preS2 deletion significantly increased the risk of HCC in patients with antiviral treatment. The prevalence of C3116T/T31C (43.61%) was higher than preS2 deletion (7.16%). By using Sleeping Beauty mouse models and in vitro experiments, we found G2950A/G2951A/A2962G/C2964A, C3116T/T31C, and preS2 deletion promoted hepatocarcinogenesis by increasing levels of inflammatory cytokines, activating STAT3 pathway, enhancing endoplasmic reticulum stress, and altering gene expression profiles in inflammation- and metabolism-related pathways. These results suggest that preS combo mutations G2950A/G2951A/A2962G/C2964A and C3116T/T31C had similar oncogenic effects of preS2 deletion and should also be monitored. This study aimed to elucidate the effects and underlying mechanisms of hepatitis B virus (HBV) preS mutations on hepatocarcinogenesis. The effect of the preS mutations on hepatocellular carcinoma (HCC) occurrence was evaluated using a prospective cohort study with 2114 HBV-infected patients, of whom 612 received antiviral treatments. The oncogenic functions of HBV preS mutations were investigated using cancer cell lines and Sleeping Beauty (SB) mouse models. RNA-sequencing and microarray were applied to identify key molecules involved in the mutant-induced carcinogenesis. Combo mutations G2950A/G2951A/A2962G/C2964A and C3116T/T31C significantly increased HCC risk in patients without antiviral treatment, whereas the preS2 deletion significantly increased HCC risk in patients with antiviral treatment. In SB mice, the preS1/preS2/S mutants induced a higher rate of tumor and higher serum levels of inflammatory cytokines than did wild-type counterpart. The preS1/preS2/S mutants induced altered gene expression profiles in the inflammation- and metabolism-related pathways, activated pathways of endoplasmic reticulum (ER) stress, affected the response to hypoxia, and upregulated the protein level of STAT3. Inhibiting the STAT3 pathway attenuated the effects of the preS1/preS2/S mutants on cell proliferation. G2950A/G2951A/A2962G/C2964A, C3116T/T31C, and preS2 deletion promote hepatocarcinogenesis via inducing ER stress, metabolism alteration, and STAT3 pathways, which might be translated into HCC prophylaxis. [ABSTRACT FROM AUTHOR]

Using the navigation signal transmitted by GNSS (global navigation satellite system), satellites for tide level monitoring comprise one of the important research fields of GNSS marine remote sensing. Regarding the problem that GNSS-MR (multipath reflectometry) technology only uses carrier SNR (signal noise ratio) data, resulting in the lack of SNR data for early CORS (continuously operating reference stations) stations, it is impossible to carry out tide level inversion. In this paper, a method of tide level inversion based on triple-frequency geometric ionospheric free combined-phase observations instead of SNR is proposed. The simultaneous interpretation of GNSS satellite observations from the sc02 station in Friday Harbor in the US is carried out and compared with the traditional GNSS-IR (interference and reflectometry) tide-inversion method. The experimental results show that the tide level inversion method proposed in this paper has the same tide level trend as the measured tide level trend. The accuracy evaluation shows that the RMSE value of tide level inversion is 15 cm and the correlation coefficient r is 0.984, which verifies the effectiveness of this method for tide level monitoring and expands the method of GNSS tide-level monitoring. [ABSTRACT FROM AUTHOR]

In the context of distributed defense, multi-sensor networks are required to be able to carry out reasonable planning and scheduling to achieve the purpose of continuous, accurate and rapid target detection. In this paper, a multi-sensor cooperative scheduling model based on the partially observable Markov decision process is proposed. By studying the partially observable Markov decision process and the posterior Cramer–Rao lower bound, a multi-sensor cooperative scheduling model and optimization objective function were established. The improvement of the particle filter algorithm by the beetle swarm optimization algorithm was studied to improve the tracking accuracy of the particle filter. Finally, the improved elephant herding optimization algorithm was used as the solution algorithm of the scheduling scheme, which further improved the algorithm performance of the solution model. The simulation results showed that the model could solve the distributed multi-sensor cooperative scheduling problem well, had higher solution performance than other algorithms, and met the real-time requirements. [ABSTRACT FROM AUTHOR]

With the rapid development of the Chinese marine economy, the anti-corrosion of ships and marine engineering facilities has become urgent to be solved. In this paper, a stable zinc-hydroxyapatite (ZnO-HAP) nanocomposite anti-corrosive pigment was prepared by using the hydrothermal in situ synthesis technique, which supported nano-ZnO onto the hydroxyapatite (HAP) surface. The phase composition, microstructure, and performance of the ZnO-HAP nanocomposite were investigated by X-ray diffraction (XRD), Fourier transform infrared (FT-IR), electron probe microanalysis (EPMA), and electrochemical impedance spectroscopy (EIS), and the anti-corrosion mechanism of the ZnO-HAP nanocomposite was discussed. The results show that the corrosion resistance of the ZnO-HAP/epoxy is better than that of the pure epoxy resin coating. The optimum condition to fabricate ZnO-HAP/epoxy with suitable corrosion resistance was found to be a ZnO/HAP ratio of 0.65/0.35. The synergistic complementation mechanism of ZnO and HAP enriches the metallic anti-corrosion theory and provides a new idea for the synthesis of novel and promising anti-corrosive pigments. [ABSTRACT FROM AUTHOR]

This paper presents a new deep neural network (DNN)-based speech enhancement algorithm by integrating the distilled knowledge from the traditional statistical-based method. Unlike the other DNN-based methods, which usually train many different models on the same data and then average their predictions, or use a large number of noise types to enlarge the simulated noisy speech, the proposed method does not train a whole ensemble of models and does not require a mass of simulated noisy speech. It first trains a discriminator network and a generator network simultaneously using the adversarial learning method. Then, the discriminator network and generator network are re-trained by distilling knowledge from the statistical method, which is inspired by the knowledge distillation in a neural network. Finally, the generator network is fine-tuned using real noisy speech. Experiments on CHiME4 data sets demonstrate that the proposed method achieves a more robust performance than the compared DNN-based method in terms of perceptual speech quality. [ABSTRACT FROM AUTHOR]

In the context of people's gradually rising consumption levels and the urgent need to upgrade the tourism market, the continuous homogenization of tourism souvenirs is beginning to seriously affect the shopping experience of tourism tourists. This study aims to explore how tourists perceive the phenomenon of the homogenization of tourism souvenirs and how this phenomenon affects tourists' continuous purchase intention. This study constructs a hypothesis model of the relationship among perceived homogeneity, perceived value, and continuous purchase intention based on a perceived value perspective and validates the model using structural equations. These findings are as follows: (1) Tourists' perceived product homogeneity and perceived service homogeneity have significant negative effects on perceived product value and continuous purchase intention. (2) Perceived service homogeneity has a significant negative effect on tourists' perceived emotional value. (3) Perceived product value and perceived emotional value have significant positive effects on continuous purchase intention. The study also explores how to enhance tourists' perceived value through innovative product design and service system construction. The findings can provide valuable insights for promoting the sustainable development of the tourism market and tourists' continuous purchase intention. [ABSTRACT FROM AUTHOR]

Emotionally sustainable design helps users to develop an emotional attachment to a product and motivates them to continue using it, thus extending the product lifecycle, minimizing the need for new products and achieving product sustainability. However, the existing relevant design principles are still very scattered, and they could not effectively guide the emotionally sustainable design practice in a systematic way. We proposed an emotionally sustainable design (ESD) toolbox for product design based on the literature review and expert argumentation. The toolbox consists of seven themes and 20 principles under the three levels of emotional design. The usability of the ESD toolbox was then validated through design practice for the teapot product. The result shows that the ESD toolbox improved the efficiency of the sustainable design process and was helpful to the product's sustainability. [ABSTRACT FROM AUTHOR]

(1) Objective: Sleep problems have become one of the current serious public health issues. The purpose of this research was to construct an ideal pressure distribution model for head and neck support through research on the partitioned support surface of a pillow in order to guide the development of ergonomic pillows. (2) Methods: Seven typical memory foam pillows were selected as samples, and six subjects were recruited to carry out a body pressure distribution experiment. The average value of the first 10% of the samples in the comfort evaluation was calculated to obtain the relative ideal body pressure distribution matrix. Fuzzy clustering was performed on the ideal matrix to obtain the support surface partition. The ideal body pressure index of each partition was calculated, and a hierarchical analysis of each partition was then performed to determine the pressure sensitivity weight of each partition. Using these approaches, the key ergonomic node coordinates of the partitions of four different groups of people were extracted. The ergonomic node coordinates and the physical characteristics of the material were used to design a pillow prototype. Five subjects were recruited for each of the four groups to repeat the body pressure distribution experiment to evaluate the pillow prototype. (3) Results: An ideal support model with seven partitions, including three partitions in the supine position and four partitions in the lateral position, was constructed. The ideal body pressure distribution matrix and ideal body pressure indicators and pressure sensitivity weights for each partition were provided. The pillow that was designed and manufactured based on this model reproduced the ideal pressure distribution matrix evaluated by various groups of people. (4) Conclusion: The seven-partition ideal support model can effectively describe the head and neck support requirements of supine and lateral positions, which can provide strong support for the development of related products. [ABSTRACT FROM AUTHOR]

Global navigation satellite system (GNSS) precise point positioning (PPP) has been widely used for high-precision time and frequency transfer. However, the day-boundary discontinuities at the boundary epochs of adjacent days or batches are the most significant obstacle preventing PPP from continuous time transfer. The day-boundary discontinuities in station estimates and time comparisons are mainly caused by the code-pseudorange noise during the analysis of observation data in daily batches, where the absolute clock offset is determined by the average code measurements. However, some discontinuities with amplitudes even more than 0.15 ns may still appear in station clock estimates and time comparisons, although several methods had been proposed to remove such discontinuities. The residual small amplitude of the day-boundary discontinuities in some PPP station clock estimates and time comparisons through new GNSSs like Galileo seems larger, especially using precise clock products with large discontinuities. To further understand the origin of the day-boundary discontinuities, the influence of GNSS precise products on the day-boundary discontinuities in PPP station clock estimates and time comparisons is investigated in this paper. Ten whole days of Multi-GNSS Experiment (MGEX) from modified Julian date (MJD) 59028 to 59037 are used as the observation data. For a comparative analysis, the station clock estimates are compared with global positioning system (GPS) and Galileo observations through PPP and network solutions, separately. The experimental results show that the daily discontinuities in current combined GPS final and rapid clock products are less than 0.1 ns, and their influence on the origin of day-boundary discontinuities in PPP station clock estimates and time comparison are statistically negligible. However, the daily discontinuities in individual Analysis Centers (ACs) GPS products are more extensive, and their influence on the origin of the day-boundary discontinuities in GPS PPP station clock estimates cannot be ignored. The day-boundary discontinuities demonstrate random walk noise characteristics and deteriorate the station clocks' long-term frequency stability, especially at an average time of more than one day. Although Galileo clock daily discontinuities are different from those of GPS, their influence on the day-boundary discontinuities in station clock estimates is nearly similar to the GPS PPP. The influence of daily discontinuities of Galileo clocks on PPP time comparison is similar to GPS and is not particularly critical to time comparison. However, combined and weighted MGEX products should be developed or Galileo IPPP should be used for remote comparison of high-stability clocks. [ABSTRACT FROM AUTHOR]

In order to provide a convenient way to strengthen the rotator cuff muscles and prevent rotator cuff injury, this study designed an innovative strength trainer specifically for shoulder rotator cuff based on oscillating hydraulic damping. We carried out a myoelectric testing experiment to evaluate the shoulder rotation training effect and compared the results with traditional training equipment to verify the feasibility and validity of the new rotator cuff trainer (RCT). Then, we further explored the influence of different training postures and motion speeds on shoulder rotation training. In the experiment, subjects used three types of equipment (RCT, dumbbells and elastic bands) to perform shoulder rotation training under two movement speeds and two motion postures. The surface electromyography (sEMG) signals of targeted muscles were collected in real time and then further analyzed. The experimental results showed that when using the RCT, the muscle force generation sequence was more aligned with the biomechanical principles of shoulder rotation than using the other two training methods, and the target training muscles had the higher percentage of muscle work. During RCT training, a higher speed of movement (120°/s) led to a higher degree of muscle activation; coronal axis rotation was better for the infraspinatus training, and sagittal axis rotation was better for teres minor training. Based on these results, the RCT was proved to be more effective than traditional training methods. In order to exercise the different muscles of rotator cuff more comprehensively and extensively, different postures should be selected. Furthermore, the movement speed can be appropriately increased within the safe range to improve muscle activation. [ABSTRACT FROM AUTHOR]

A running exhaustion experiment was used to explore the correlations between the time-frequency domain indexes extracted from the surface electromyography (EMG) signals of targeted muscles, heart rate and exercise intensity, and subjective fatigue. The study made further inquiry into the feasibility of reflecting and evaluating the exercise intensity and fatigue effectively during running using physiological indexes, thus providing individualized guidance for running fitness. Twelve healthy men participated in a running exhaustion experiment with an incremental and constant load. The percentage of heart rate reserve (%HRR), mean power frequency (MPF) and root mean square (RMS) from surface EMG (sEMG) signals of the rectus femoris (RF), biceps femoris (BF), tibialis anterior muscle (TA), and the lateral head of gastrocnemius (GAL) were obtained in real-time. The data were processed and analyzed with the rating of perceived exertion (RPE) scale. The experimental results show that the MPF on all the muscles increased with time, but there was no significant correlation between MPF and RPE in both experiments. Additionally, there was no significant correlation between RMS and RPE of GAL and BF, but there was a negative correlation between RMS and RPE of RF. The correlation coefficient was lower in the constant load mode, with the value of only −0.301. The correlation between RMS and RPE of TA was opposite in both experiments. There was a significant linear correlation between %HRR and exercise intensity (r = 0.943). In the experiment, %HRR was significantly correlated with subjective exercise fatigue (r = 0.954). Based on the above results, the MPF and RMS indicators on the four targeted muscles could not conclusively identify fatigue of lower extremities during running. The %HRR could be used to identify exercise intensity and human fatigue during running and could be used as an indicator of recognizing fatigue and exercise intensity in runners. [ABSTRACT FROM AUTHOR]

This study examines the effect of a target firm's corporate social responsibility (CSR) on its cross-border acquisition premium. Building upon the resource-based view and the institutional theory, we argue that the target firm's CSR positively affect the cross-border acquisition premium, while institutional distance, cultural distance, and the number of fellow acquisitions moderate the above relationship. Hypotheses are tested in a sample of 252 cross-border acquisitions between 1991 and 2016. Empirical findings show that an acquirer is more likely to pay a higher acquisition premium when acquiring a socially responsible target firm; furthermore, such an effect weakens as institutional distance, cultural distance, and the number of fellow acquisitions increase. This study extends existing research on the importance of CSR as a strategic asset and sheds new light on the role of CSR played in the setting of cross-border acquisitions. [ABSTRACT FROM AUTHOR]

For suppressing the crosstalk problem due to wire resistances and contacted resistances of the long flexible cables in tactile sensing systems, we present a novel two-wire fast readout approach for the two-dimensional resistive sensor array in shared row-column fashion. In the approach, two wires are used for every driving electrode and every sampling electrode in the resistive sensor array. The approach with a high readout rate, though it requires a large number of wires and many sampling channels, solves the cable crosstalk problem. We also verified the approach's performance with Multisim simulations and actual experiments.

Using a long, flexible test cable connected with a one-wire voltage feedback circuit, a resistive tactile sensor in a shared row-column fashion exhibited flexibility in robotic operations but suffered from crosstalk caused by the connected cable due to its wire resistances and its contacted resistances. Firstly, we designed a new non-scanned driving-electrode (VF-NSDE) circuit using two wires for every row line and every column line to reduce the crosstalk caused by the connected cables in the circuit. Then, an equivalent resistance expression of the element being tested (EBT) for the two-wire VF-NSDE circuit was analytically derived. Following this, the one-wire VF-NSDE circuit and the two-wire VF-NSDE circuit were evaluated by simulation experiments. Finally, positive features of the proposed method were verified with the experiments of a two-wire VF-NSDE prototype circuit. The experiment results show that the two-wire VF-NSDE circuit can greatly reduce the crosstalk error caused by the cables in the 2-D networked resistive sensor array.

The 2-D resistive sensor array in the row-column fashion suffered from the crosstalk problem for parasitic parallel paths. Firstly, we proposed an Improved Isolated Drive Feedback Circuit with Compensation (IIDFCC) based on the voltage feedback method to suppress the crosstalk. In this method, a compensated resistor was specially used to reduce the crosstalk caused by the column multiplexer resistors and the adjacent row elements. Then, a mathematical equivalent resistance expression of the element being tested (EBT) of this circuit was analytically derived and verified by the circuit simulations. The simulation results show that the measurement method can greatly reduce the influence on the EBT caused by parasitic parallel paths for the multiplexers' channel resistor and the adjacent elements.