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Fe-Si-Cr soft magnetic powder cores (SMCs), with high electrical resistivity, magnetic permeability, saturation magnetic induction, and good corrosion resistance, are widely applied to inductors, filters, choke coils, etc. However, with the development of electronic technology with high frequency and high power density, the relative decline in the magnetic properties limits the high-frequency application of SMCs. In this paper, the phosphating process and polyimide (PI) insulation coating is applied to Fe-Si-Cr SMCs to reduce the core loss, including hysteresis loss and eddy current loss. The microstructure and composition of Fe-Si-Cr powders were analyzed by SEM, XRD, and Fourier-transform infrared spectra, respectively. The structural characteristics of the Fe-Si-Cr @ phosphate layer @ PI layer core–shell double coating were studied, and the best process parameters were determined through experiments. For SMCs with 0.4 wt% content of PI, the relative permeability is greater than 68%, and the core loss is the lowest, 7086 mW/cm3; annealed at 500 °C, the relative permeability is greater than 57%, and the core loss is the lowest, 6222 mW/cm3. A 0.4 wt% content of PI, annealed at 500 °C, exhibits the ideal magnetic properties: μe = 47 H/m, P = 6222 mW/cm3. [ABSTRACT FROM AUTHOR]

Modern explosion protection equipment, protected by traditional explosion protection technology (as defined by the international electrotechnical commission (IEC) publication IEC60079-ff series standards) and electrical/electronic/programmable electronic (E/E/PE) safety-related systems, is becoming ever more complex in coal mine development and petrochemical industry; thus, the possibility of failures in their operation is also growing. It is well-known that E/E/PE safety-related systems can be used to actively control dangerous sources, with real and expected levels of reliability, if they have been qualified according to the IEC61508-ff series standards. To uniformly evaluate the safety integrity level (SIL) of the explosion protection function of traditional explosion protection technology and E/E/PE safety-related system technology, this study analyzed the ability of these types of protection to remove the ignition risk residual, evaluating the failure rates of safety devices. The key objective of this paper is the presentation of a new equipment protection level (EPL) assessment method for explosion protection equipment based on a functional safety assessment. The method is applied to a variable frequency drive (VFD) system, and the results show that the EPL of the explosion protection equipment evaluated by this method is consistent with the EPL corresponding to the traditional explosion protection type of the IEC60079-ff series standard. Meanwhile, the flexible configuration of explosion protection safety devices and E/E/PE safety-related systems enables explosion protection equipment of different EPL levels to be designed. [ABSTRACT FROM AUTHOR]

Studies on ESRRB-regulating porcine-induced pluripotent stem cells (piPSCs) converted to trophoblast-like stem cells (TLSCs) contribute to the understanding of early embryo development. However, the epigenetic modification regulation network during the conversion is poorly understood. Here, the global change in histone H3 Lysine 4, 9, 27, 36 methylation and Lysine 27 acetylation was investigated in piPSCs and TLSCs. We found a high modification profile of H3K36me2 in TLSCs compared to that of piPSCs, whereas the profiles of other modifications remained constant. KDM4C, a H3K36me3/2 demethylase, whose gene body region was combined with ESRRB, was upregulated in TLSCs. Moreover, KDM4 inhibitor supplementation rescued the AP-negative phenotype observed in TLSCs, confirming that KDM4C could regulate the pluripotency of TLSCs. Subsequently, KDM4C replenishment results show the significantly repressed proliferation and AP-positive staining of TLSCs. The expressions of CDX2 and KRT8 were also upregulated after KDM4C overexpression. In summary, these results show that KDM4C replaced the function of ESRRB. These findings reveal the unique and crucial role of KDM4C-mediated epigenetic chromatin modifications in determination of piPSCs' fate and expand the understanding of the connection between piPSCs and TSCs. [ABSTRACT FROM AUTHOR]

The large mining height fully mechanized top-coal caving mining technique has developed rapidly and become the most extensively used mining method for ultra-thick coal seams. The arching of coal/gangue and the drawing out of gangue are peculiar phenomena in the process of fully mechanized top-coal caving mining, which not only affects the recovery of top-coal, but also affects the quality of the coal. This paper studies the arching phenomenon in top-coal caving mining process of ultra-thick coal seam. A series of laboratory granular material simulation experiments were performing and a top-coal arching model in the framework of mechanics was established to explore the formation characteristic of arches and their effects to top-coal loss. Then the countermeasures against the arches and technology path of intelligent mining based on improving top-coal recovery were put forward and performed in practice. The results show that the recovery ratio of top-coal has increased nearly 6%, and increased the production efficiency at the same time. The research on arching mechanism and removing strategies of dynamic random arches effectively improves the efficiency of fully mechanized top-coal caving mining in ultra-thick coal seams, and provides the foundation for the realization of intelligent top-coal caving mining technology. [ABSTRACT FROM AUTHOR]

The establishment of porcine pluripotent stem cells (piPSCs) is critical but remains challenging. All piPSCs are extremely sensitive to minor perturbations of culture conditions and signaling network. Inhibitors, such as CHIR99021 and XAV939 targeting the WNT signaling pathway, have been added in a culture medium to modify the cell regulatory network. However, potential side effects of inhibitors could confine the pluripotency and practicability of piPSCs. This study aimed to investigate the roles of AXIN, one component of the WNT pathway in piPSCs. Here, porcine AXIN1 and AXIN2 genes were knocked-down or overexpressed. Digital RNA-seq was performed to explore the mechanism of cell proliferation and apoptosis. We found that (1) overexpression of the porcine AXIN2 gene significantly reduced survival and negatively impacted the pluripotency of piPSCs, and (2) knockdown of AXIN2, a negative effector of the WNT signaling pathway, enhanced the expression of genes involved in cell cycle but reduced the expression of genes related to cell differentiation, death, and apoptosis. [ABSTRACT FROM AUTHOR]

Multi-level converters are widely used in various industrial applications. Among various space vector modulation (SVM) schemes, the multi-level SVM scheme based on two-level space vector pulse width modulation (SVPWM) is recognised as a simplified multi-level SVM scheme, which can reduce the computation complexity. However, this scheme is still complicated when the number of the voltage levels is large. This paper proposes a modified SVM scheme that can further simplify the multi-level SVM scheme based on two-level SVPWM. The proposed SVM scheme can directly determine the two-level hexagon where the reference voltage vector is located by calculating a simple formula. The whole modulation process can be completed by only three steps. Meanwhile, the proposed method is generic for any n-level converter without adding much calculation, which greatly simplifies the modulation process. Experimental results have been provided, which verify the effectiveness and generality of the proposed SVM scheme for two types of multi-level converters. [ABSTRACT FROM AUTHOR]

In this work, a two-phase system composed of hydrophobic ionic liquid (IL) and water phases was introduced to prepare copper sulfide (CuS) nanoparticles. It was found that CuS particles generated from the interfaces of carboxyl-functionalized IL and sodium sulfide (Na2S) aqueous solution were prone to aggregate into nanoplates and those produced from the interfaces of carboxyl-functionalized IL and thioacetamide (TAA) aqueous solution tended to aggregate into nanospheres. Both the CuS nanoplates and nanospheres exhibited a good absorption ability for ultraviolet and visible light. Furthermore, the CuS nanoplates and nanospheres showed highly efficient photocatalytic activity in degrading rhodamine B (RhB). Compared with the reported CuS nanostructures, the CuS nanoparticles prepared in this work could degrade RhB under natural sunlight irradiation. Finally, the production of CuS from the interfaces of hydrophobic IL and water phases had the advantages of mild reaction conditions and ease of operation. [ABSTRACT FROM AUTHOR]

In low and medium voltage power conversion systems, multilevel converters are becoming more and more attractive due to improved power density. However, the complexity of topology and control is a big challenge for the application of multilevel converters. In this paper, a four-level (4L) hybrid flying capacitor (FC) T-type converter has been researched in detail. The topological advantage of the converter is displayed in comparison to existing four-level converters. According to the feature of the topology, the operating status has been analyzed and the reason for the voltage jump is researched in detail during the dead-time period. A strategy to reduce voltage jump by adjusting the switching states has be presented. The FC voltages can be balanced by selecting the appropriate switching states. The relationships between the fluctuations of FC voltages and the modulation index and power factor (PF) have been analyzed by simulation results. The performance of the 4L converter has been investigated in MATLAB/Simulink as well as on a down-scaled laboratory prototype. [ABSTRACT FROM AUTHOR]