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Start Over Author "Yuan, Rongxin" Publisher mdpi
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1. An Efficient, One-Pot Transamidation of 8-Aminoquinoline Amides Activated by Tertiary-Butyloxycarbonyl.

Author

Wu, Wengang, Yi, Jun, Xu, Huipeng, Li, Shuangjun, Yuan, Rongxin, and Orru, Romano V. A.

Subjects
CHEMICAL reactions, HETEROCYCLIC compounds, NANOPARTICLES, CATALYSIS, PALLADIUM, ARYLATION
Abstract

The efficient, one-pot access to the transamidation of 8-aminoquinoline (8-AQ), notorious for its harsh removal conditions, has been widely employed as an auxiliary in C–H functionalization reactions due to its strong directing ability. In this study, the facile and mild Boc protection of the corresponding 8-AQ amide was critical to activate the amide C(acyl)–N bond by twisting its geometry to lower the amidic resonance energy. Both aryl and alkyl amines proceeded transamidation in one-pot, user-friendly conditions with excellent yields. [ABSTRACT FROM AUTHOR]

Published
2019
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