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Team score orienteering, a challenging and interesting sport, is gradually becoming known by the majority of sports enthusiasts. Integrating team score orienteering with the Internet can enhance the interactive experience for athletes. However, this integration increases the risk of the leakage of the athletes' information. In order to protect the privacy of athletes, it is necessary to employ encryption. Therefore, this paper proposes an efficient lattice-based revocable certificateless public key encryption (RCL-PKE) scheme with decryption key exposure resistance (DKER). The adoption of certificateless encryption not only avoids the complex certificate management required for traditional public key encryption, but also addresses the key escrow problem of identity-based encryption, thereby significantly ensuring data security and privacy. Furthermore, the revocable mechanism enables the organizing committee to flexibly manage the athletes' qualification for competitions, and DKER can effectively prevent the leakage of decryption keys, which further enhances data security. The constructed RCL-PKE scheme was proven to be IND-CPA secure under the learning with errors (LWE) assumption. Experiments indicated that the proposed RCL-PKE scheme had lower computation and communication costs, making it particularly suitable for team score orienteering. [ABSTRACT FROM AUTHOR]

In many universities, students' physical ability data are collected and stored in the cloud through various sensing devices to save computational and storage costs. Therefore, how to effectively access data while ensuring data security has become an urgent issue. Key-policy attribute-based encryption (KP-ABE) not only enables secure one-to-many communication and fine-grained access control but also adapts to data sharing in static scenarios, making it more suitable for the cloud sharing of physical ability data. In this paper, we construct an online/offline multi-authority key-policy attribute-based encryption with a cryptographic reverse firewall for physical ability data. This scheme uses multi-authority to avoid the single point of failure crisis of a single authority, and is combined with a cryptographic reverse firewall to resist backdoor attacks. In addition, the scheme uses outsourcing decryption to save users' computing costs, and utilizes offline/online technology to move a large amount of computing offline, reducing the online burden. Finally, the experiment shows the feasibility of the scheme. [ABSTRACT FROM AUTHOR]

Cross-interference is not only an important factor that affects the measuring accuracy of three-dimensional force sensors, but also a technical difficulty in three-dimensional force sensor design. In this paper, a cross-interference suppression method is proposed, based on the octagonal ring's structural symmetry as well as Wheatstone bridge's balance principle. Then, three-dimensional force sensors are developed and tested to verify the feasibility of the proposed method. Experimental results show that the proposed method is effective in cross-interference suppression, and the optimal cross-interference error of the developed sensors is 1.03%. By optimizing the positioning error, angle deviation, and bonding process of strain gauges, the cross-interference error of the sensor can be further reduced to −0.36%. [ABSTRACT FROM AUTHOR]

Urbanization has led to rapid growth in energy consumption and CO2 emissions in the building sector. Building operation emissions (BCEs) are a major part of emissions in the building life cycle. Existing studies have attempted to estimate fine-scale BCEs using remote sensing data. However, there is still a lack of research on estimating long-term BCEs by integrating multi-source remote sensing data and applications in different regions. We selected the Beijing–Tianjin–Hebei (BTH) urban agglomeration and the National Capital Region of Japan (NCRJ) as research areas for this study. We also built multiple linear regression (MLR) models between prefecture-level BCEs and multi-source remote sensing data. The prefecture-level BCEs were downscaled to grid scale at a 1 km2 resolution. The estimation results verify the method's difference and accuracy at different development stages. The multi-scale BCEs showed a continuous growth trend in the BTH urban agglomeration and a significant downward trend in the NCRJ. The decrease in energy intensity and population density were the main factors contributing to the negative growth of BCEs, whereas GDP per capita and urban expansion significantly promoted it. Through our methods and analyses, we contribute to the study of estimating greenhouse gas emissions with remote sensing and exploring the environmental impact of urban growth. [ABSTRACT FROM AUTHOR]

While Buddhist teachings deny the presence of a stable, unchanging self, they must still make sense of human agency. In this article, I look through metaphors of mechanical men in Buddhist literature, which inform us of attempts to tackle the problem by resorting to figurative speech. With a selection of examples, we shall see not only a basic rationale of these metaphors, as well as the dynamics of their usage in Buddhist texts against different doctrinal backgrounds, but also their meta-philosophical role in penetrating through the agent-oriented "universe of discourse". [ABSTRACT FROM AUTHOR]

Pulmonary arterial hypertension (PAH) is a progressive and inevitably fatal disease characterized by the progressive increase of pulmonary vascular resistance and obliterative pulmonary vascular remodeling, which lead to right-sided heart failure and premature death. Many of the genetically modified mouse models do not develop severe PH and occlusive vascular remodeling. Egln1Tie2Cre mice with Tie2Cre-mediated deletion of Egln1, which encodes hypoxia-inducible factor (HIF) prolyl hydroxylase 2 (PHD2), is the only mouse model with severe PAH, progressive occlusive pulmonary vascular remodeling, and right-sided heart failure leading to 50–80% mortality from the age of 3–6 months, indicating that the Egln1Tie2Cre mice model is a long-sought-after murine PAH model. However, it is unknown if Egln1Tie2Cre mice respond to FDA-approved PAH drugs in a way similar to PAH patients. Here, we tested the therapeutic effects of the three vasodilators: sildenafil (targeting nitric oxide signaling), ambrisentan (endothelin receptor antagonist), and treprostinil (prostacyclin analog) on Egln1Tie2Cre mice. All of them attenuated right ventricular systolic pressure (RVSP) in Egln1Tie2Cre mice consistent with their role as vasodilators. However, these drugs have no beneficial effects on pulmonary arterial function. Cardiac output was also markedly improved in Egln1Tie2Cre mice by any of the drug treatments. They only partially improved RV function and reduced RV hypertrophy and pulmonary vascular remodeling as well as improving short-term survival in a drug-dependent manner. These data demonstrate that Egln1Tie2Cre mice exhibit similar responses to these drugs as PAH patients seen in clinical trials. Thus, our study provides further evidence that the Egln1Tie2Cre mouse model of severe PAH is an ideal model of PAH and is potentially useful for enabling identification of drug targets and preclinical testing of novel PAH drug candidates. [ABSTRACT FROM AUTHOR]

The pulmonary route has long been used for drug administration for both local and systemic treatment. It possesses several advantages, which can be categorized into physiological, i.e., large surface area, thin epithelial membrane, highly vascularized, limited enzymatic activity, and patient convenience, i.e., non-invasive, self-administration over oral and systemic routes of drug administration. However, the formulation of dry powder for pulmonary delivery is often challenging due to restrictions on aerodynamic size and the lung's lower tolerance capacity in comparison with an oral route of drug administration. Various physicochemical properties of dry powder play a major role in the aerosolization, deposition, and clearance along the respiratory tract. To prepare suitable particles with optimal physicochemical properties for inhalation, various manufacturing methods have been established. The most frequently used industrial methods are milling and spray-drying, while several other alternative methods such as spray-freeze-drying, supercritical fluid, non-wetting templates, inkjet-printing, thin-film freezing, and hot-melt extrusion methods are also utilized. The aim of this review is to provide an overview of the respiratory tract structure, particle deposition patterns, and possible drug-clearance mechanisms from the lungs. This review also includes the physicochemical properties of dry powder, various techniques used for the preparation of dry powders, and factors affecting the clinical efficacy, as well as various challenges that need to be addressed in the future. [ABSTRACT FROM AUTHOR]

There are currently no effective treatments for sepsis and acute respiratory distress syndrome (ARDS). The repositioning of existing drugs is one possible effective strategy for the treatment of sepsis and ARDS. We previously showed that vascular repair and the resolution of sepsis-induced inflammatory lung injury is dependent upon endothelial HIF-1α/FoxM1 signaling. The aim of this study was to identify a candidate inducer of HIF-1α/FoxM1 signaling for the treatment of sepsis and ARDS. Employing high throughput screening of a library of 1200 FDA-approved drugs by using hypoxia response element (HRE)-driven luciferase reporter assays, we identified Rabeprazole (also known as Aciphex) as a top HIF-α activator. In cultured human lung microvascular endothelial cells, Rabeprazole induced HIF1A mRNA expression in a dose-dependent manner. A dose-response study of Rabeprazole in a mouse model of endotoxemia-induced inflammatory lung injury identified a dose that was well tolerated and enhanced vascular repair and the resolution of inflammatory lung injury. Rabeprazole treatment resulted in reductions in lung vascular leakage, edema, and neutrophil sequestration and proinflammatory cytokine expression during the repair phrase. We next used Hif1a/Tie2Cre knockout mice and Foxm1/Tie2Cre knockout mice to show that Rabeprazole promoted vascular repair through HIF-1α/FoxM1 signaling. In conclusion, Rabeprazole is a potent inducer of HIF-1α that promotes vascular repair and the resolution of sepsis-induced inflammatory lung injury via endothelial HIF-1α/FoxM1 signaling. This drug therefore represents a promising candidate for repurposing to effectively treat severe sepsis and ARDS. [ABSTRACT FROM AUTHOR]

Porcine epidemic diarrhea virus (PEDV) is the major pathogen that causes diarrhea and high mortality in newborn piglets, with devastating impact on the pig industry. To further understand the molecular epidemiology and genetic diversity of PEDV field strains, in this study the complete genomes of four PEDV variants (HN2021, CH-HNYY-2018, CH-SXWS-2018, and CH-HNKF-2016) obtained from immunized pig farms in central China between 2016 to 2021 were characterized and analyzed. Phylogenetic analysis of the genome and S gene showed that the four strains identified in the present study had evolved into the subgroup G2a, but were distant from the vaccine strain CV777. Additionally, it was noteworthy that a new PEDV strain (named HN2021) belonging to the G2a PEDV subgroup was successfully isolated in vitro and it was further confirmed by RT-PCR that this isolate had a large natural deletion at 207–373 nt of the ORF3 gene, which has never been reported before. Particularly, in terms of pathogenicity evaluation, colostrum deprivation piglets challenged with PEDV HN2021 showed severe diarrhea and high mortality, confirming that PEDV HN2021 was a virulent strain. Hence, PEDV strain HN2021 of subgroup G2a presents a promising vaccine candidate for the control of recurring porcine epidemic diarrhea (PED) in China. This study lays the foundation for better understanding of the genetic evolution and molecular pathogenesis of PEDV. [ABSTRACT FROM AUTHOR]

The metabolites of the genus Marasmius are diverse, showing good research prospects for finding new bioactive molecules. In order to explore the active metabolites of the fungi Marasmius berteroi, the deep chemical investigation on the bioactive compounds from its cultures was undertaken, which led to the isolation of three new naphthalene compounds dipolynaphthalenes A–B (1,2) and naphthone C (3), as well as 12 known compounds (4–15). Compounds 1, 2, and 4 are dimeric naphthalene compounds. Their structures were elucidated by MS, 1D and 2D NMR spectroscopic data, as well as ECD calculations. Compounds 2–4 and 7 exhibited acetylcholinesterase (AChE) inhibitory activities at the concentration of 50 μg/mL with inhibition ratios of 42.74%, 44.63%, 39.50% and 51.49%, respectively. Compounds 5 and 7,8 showed weak inhibitory activities towards two tumor cell lines, with IC50 of 0.10, 0.076 and 0.058 mM (K562) and 0.13, 0.18, and 0.15 mM (SGC-7901), respectively. [ABSTRACT FROM AUTHOR]

Six new phragmalin limonoids, named moluccensin Z1 (1), moluccensin Z2 (2), carapanolide Y (3), tabulalin N (4), chukvelutilide A1 (5), and velutinasin J (6), as well as two known compounds, chukvelutilide A (7) and velutinasin D (8) were isolated from the stems of Chukrasia tabularis A. Juss. The structures of the new compounds 1–6 were confirmed by spectroscopic methods, including IR and HRESIMS, as well as 1D and 2D NMR, and by comparisons with the data of known analogues. All compounds were tested for α-glucosidase and acetylcholinesterase inhibitory activities. However, none of the compounds was active against α-glucosidase and acetylcholinesterase in vitro. [ABSTRACT FROM AUTHOR]

Daphnauranins C–E (compounds 1–3), two sesquiterpenoids and one monoterpenoid were isolated from the roots of Daphne aurantiaca Diels. Daphnauranin C is a 9-O-13 etherified and hydroperoxy-substituted guaiane sesquiterpenoid, daphnauranin D is a guaiane sesquiterpenoid ketal, and daphnauranin E is a monoterpenoid lactone. Their structures were elucidated by comprehensive analyses of MS, 1D NMR, and 2D NMR spectroscopic data. In an anti-feeding activities test, daphnauranins C–E showed activity against male fruit fly with anti-feeding indexes (AI) up to 39.1, 39.2, and 27.8% respectively, at 1 mM. [ABSTRACT FROM AUTHOR]