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Your search keyword '"Zhengzhong Xu"' showing total 2 results
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2 results on '"Zhengzhong Xu"'

1. Astaxanthin Protects Dendritic Cells from Lipopolysaccharide-Induced Immune Dysfunction

Author

Dongrui Sun, Chunmei Li, Jin Yang, Yinyan Yin, Nuo Xu, Bangyue Zhou, Zhengzhong Xu, Bixia Ma, and Yi Shi

Subjects
Lipopolysaccharides, Male, 0301 basic medicine, Lipopolysaccharide, QH301-705.5, T cell, Anti-Inflammatory Agents, Pharmaceutical Science, chemical and pharmacologic phenomena, Xanthophylls, Article, Proinflammatory cytokine, sepsis, Mice, 03 medical and health sciences, chemistry.chemical_compound, immune dysfunction, 0302 clinical medicine, Immune system, Cell Movement, Astaxanthin, Drug Discovery, medicine, Animals, dendritic cells, Biology (General), Pharmacology, Toxicology and Pharmaceutics (miscellaneous), CD86, CD40, integumentary system, biology, organic chemicals, lipopolysaccharide, food and beverages, hemic and immune systems, Endocytosis, Cell biology, Mice, Inbred C57BL, astaxanthin, 030104 developmental biology, medicine.anatomical_structure, chemistry, 030220 oncology & carcinogenesis, biology.protein, Cytokines, Biomarkers, Immunosuppressive Agents, CD80
Abstract

Astaxanthin, originating from seafood, is a naturally occurring red carotenoid pigment. Previous studies have focused on its antioxidant properties, however, whether astaxanthin possesses a desired anti-inflammatory characteristic to regulate the dendritic cells (DCs) for sepsis therapy remains unknown. Here, we explored the effects of astaxanthin on the immune functions of murine DCs. Our results showed that astaxanthin reduced the expressions of LPS-induced inflammatory cytokines (TNF-α, IL-6, and IL-10) and phenotypic markers (MHCII, CD40, CD80, and CD86) by DCs. Moreover, astaxanthin promoted the endocytosis levels in LPS-treated DCs, and hindered the LPS-induced migration of DCs via downregulating CCR7 expression, and then abrogated allogeneic T cell proliferation. Furthermore, we found that astaxanthin inhibited the immune dysfunction of DCs induced by LPS via the activation of the HO-1/Nrf2 axis. Finally, astaxanthin with oral administration remarkably enhanced the survival rate of LPS-challenged mice. These data showed a new approach of astaxanthin for potential sepsis treatment through avoiding the immune dysfunction of DCs.

Published
2021

2. Differential Effects of Mycobacterium bovis BCG on Macrophages and Dendritic Cells from Murine Spleen.

Author

Zhengzhong Xu, Chuang Meng, Bin Qiang, Hongyan Gu, Lin Sun, Yuelan Yin, Zhiming Pan, Xiang Chen, and Xinan Jiao

Subjects
*MYCOBACTERIUM bovis, *MACROPHAGES, *DENDRITIC cells, *MYCOBACTERIAL diseases, *BCG vaccines, *NITRIC-oxide synthases, *T cells
Abstract

Macrophages (MΦ) and dendritic cells (DCs) are both pivotal antigen presenting cells capable of inducing specific cellular responses to inhaled mycobacteria, and thus, they may be important in the initiation of early immune responses to mycobacterial infection. In this study, we evaluated and compared the roles of murine splenic DCs and MΦs in immunity against Mycobacterium bovis Bacillus Calmette-Guérin (M.bovis BCG). The number of internalized rBCG-GFP observed was obviously greater in murine splenic MΦs compared with DCs, and the intracellular reactive oxygen species (ROS), inducible nitric oxide synthase (iNOS) and nitric oxide (NO) levels in MΦs were all higher than in DCs. DCs have a stronger capacity for presenting Ag85A peptide to specific T hybridoma and when the murine splenic MΦs were infected with BCG and rBCG::Ag85A, low level of antigen presenting activity was detected. These data suggest that murine splenic MΦs participate in mycobacteria uptake, killing and inducing inflammatory response, whereas the murine splenic DCs are primarily involved in specific antigen presentation and T cell activation. [ABSTRACT FROM AUTHOR]

Published
2015
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