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The rectangular pipe jacking method is an efficient, green, trenchless technology for constructing urban underground space. However, some problems, including the high jacking resistance, the instability of the tunneling face, and excessive ground settlement during the large-section rectangular pipe jacking for the underpass of national highways, seriously affect construction safety and traffic. Based on the engineering background of the large-section rectangular pipe jacking in constructing the subway entrance tunnel of Guangzhou Metro Line 7, this work adopts the methods of theoretical calculation, numerical simulation, and engineering application. Five kinds of mechanical models for pipe soil slurry interactions in rectangular pipe jacking are analyzed. An evaluation of the applicability of the jacking force prediction of the different models is conducted. Moreover, the ground settlement law for the large-section rectangular pipe jacking for the underpass of national highways under different influencing factors, including slurry sleeve thickness, grouting pressure, and earth chamber pressure, is revealed. The control countermeasures of the ground settlements, such as installing a waterproof rubber curtain for the tunnel portal, pipe jacking machine receiving techniques, thixotropic slurry for reducing friction resistance, and soil stability at the tunneling face, are carried out. The results show that there is no need to install an intermediate jacking station in the large-section rectangular pipe jacking project with a jacking distance of 63 m. The most reasonable thickness of the thixotropic slurry sleeve is about 150 mm. The most reasonable grouting pressure range is 600–700 kPa. An earth chamber pressure of about 153 kPa is more reasonable to control the soil stability of the tunneling face. The engineering practice shows that the maximum ground settlement of the national highway during jacking is 10 mm. The maintenance effect is excellent, and the traffic operates normally. [ABSTRACT FROM AUTHOR]

Double-roadway tunneling could mitigate the contradiction between mining production needs and tunneling speed, which is pivotal to the sustainable development of underground mines. However, it is very difficult to control the stability of a mining roadway on an adjacent working face suffering from strong mining disturbance due to double-roadway tunneling, especially at a large mining height working face. In order to control the stability of the return air roadway (RAR) 23205 of a strong mining roadway at working face 23205 in the Zhuanlongwan Coal Mine in Inner Mongolia, we carried out field monitoring, theoretical analysis, numerical simulations, and engineering practice to identify the main factors influencing the deformations and the stress distribution law of the surrounding rock in order to propose countermeasures for strong mining roadways. The results show the factors influencing the large deformation of strong mining roadways include large mining height, repeated mining, stress concentration due to the large coal pillar, and a small thickness of the anchorage layer in the roof. The stress peak in the central coal pillar caused by the first and second mining is 23.19 MPa and 27.49 MPa, respectively, and the stress concentration coefficients are 4.538 and 5.379, respectively. Countermeasures (pressure relief via large-diameter boreholes in the large coal pillar and long anchorage for roof reinforcement) were created to control the stability of a strong mining roadway, i.e., RAR 23205. Field measurements indicated that deformations in RAR 23205 could be efficiently controlled. The maximum deformation of the surrounding rock was 50 mm, which meets the safety and efficient production requirements of the coal mine. In addition, new roadway layout optimization and control countermeasures are put forward to control the stability of mining roadways. [ABSTRACT FROM AUTHOR]

Echinacea purpurea (L.) Moench (EP) is a well-known botanical supplement with antioxidant characteristics. However, the effects of EP on oxidative stress induced by hyperthyroidism have not yet been studied. This study was designed to evaluate the antioxidative effect of ethanolic Echinacea Purpurea (EEP) on hyperthyroidism-induced oxidative stress mice using an integrated strategy combining transcriptomics with network pharmacology analysis. Firstly, a hyperthyroidism mice model was induced via thyroxine (160 mg/kg) and EEP (1, 2, or 4 g/kg) once daily for 2 weeks. Body weight, thyroid-stimulating hormones, and oxidative stress markers were tested. Secondly, EEP regulating the potential genes at transcript level were analyzed. Thirdly, a network pharmacology based on the constituents of EEP identified using UPLC-Q-TOF-MS analysis was adopted. Finally, a joint analysis was performed to identify the key pathway. The results showed that EEP significantly changed the thyroid-stimulating hormones and oxidative stress markers. Meanwhile, RT-qPCR and Western Blotting demonstrated that the mechanism of the antioxidant effect of EEP reversed the mRNA expression of EHHADH, HMGCR and SLC27A2 and the protein expression of FABP and HMGCR in AMPK and PPAR signaling pathways. This study integrates transcriptomics with network pharmacology to reveal the mechanism of ameliorative effect of EEP on hyperthyroidism-induced oxidative stress. [ABSTRACT FROM AUTHOR]

In order to reduce the sintering temperature and improve the mechanical properties of B4C ceramics, ZrB2 was formed in situ using the SPS sintering method with ZrO2 and B4C as raw materials. Thermodynamic calculations revealed that CO pressure affected the formation of ZrB2 at temperatures from 814 °C to 1100 °C. The experimental results showed that the ZrB2 grain size was <5 µm and that the grains were uniformly distributed within the B4C ceramics. With an increase in ZrO2 content, the Vickers hardness and flexural strength of the B4C ceramics first increased and then decreased, while the fracture toughness continuously increased. When the content of ZrO2 was 15 wt%, the Vickers hardness, fracture toughness and flexural strength of B4C ceramics were 35.5 ± 0.63 GPa, 3.6 ± 0.24 MPa·m1/2 and 403 ± 10 MPa, respectively. These results suggest that ZrB2 inhibits B4C grain growth, eliminates crack tip stress, and provides fine grain to strengthen and toughen B4C ceramics. [ABSTRACT FROM AUTHOR]

Lepidium meyenii Walp. (Maca), as a natural food supplement, has strong antioxidant and energy metabolism-improving characteristics, and Maca polysaccharide (MP) is its effective component. MP has been shown to mitigate liver damage in previous research, and Cyclophosphamide (CYP)-induced hepatotoxicity is also a major concern in clinical practice. We investigated the possible cytoprotective effect of MP on CYP-induced liver injury, and explored its underlying mechanism by analyzing the resulting liver metabolic profiles. MP significantly inhibited increases in serum transaminase, improved pathological changes, reduced oxidative stress, and increased the levels of energy metabolism-related enzymes. Metabolomic analysis showed that MP corrected lipid metabolic problems and regulated the pentose phosphate pathway and acid metabolism, thereby protecting against apoptosis of hepatocytes. The Pearson correlation analysis indicated that antioxidant enzymes and energy metabolism-related enzymes are closely correlated with these differential metabolites. In addition, the upstream Keap1-Nrf2 antioxidant signal transduction pathway was explored to validate the possible mechanism of the cytoprotective effect of MP. In conclusion, MP plays a protective role in CYP-induced hepatotoxicity through these potential metabolic means, where it ameliorates oxidative stress, improves energy metabolism, and restores mitochondrial respiration by regulating the Keap1-Nrf2 signaling pathway, thereby preventing liver damage. [ABSTRACT FROM AUTHOR]

In order to solve the problem that bolts in traditional packaged direct methanol fuel cells (DMFCs) take up a large area and reduce the specific energy (energy per unit weight) and power density (power per unit area), a new button-type micro direct methanol fuel cell (B-μDMFC) is designed, assembled, and packaged. The cell with four different structures was tested before and after packaging. The results indicate that the button cell with three-dimensional graphene and springs has the best performance. The equivalent circuit and methanol diffusion model was applied to explain the experimental results. The peak volumetric specific power density of the cell is 11.85 mW cm−3. This is much higher than traditional packaged DMFC, because the novel B-μDMFC eliminates bolts in the structure and improves the effective area ratio of the cell. [ABSTRACT FROM AUTHOR]

Echinacea purpurea (L.) Moench (EP) is a well-known botanical supplement with antioxidant characteristics. However, the effects of EP on oxidative stress induced by hyperthyroidism have not yet been studied. This study was designed to evaluate the antioxidative effect of ethanolic Echinacea Purpurea (EEP) on hyperthyroidism-induced oxidative stress mice using an integrated strategy combining transcriptomics with network pharmacology analysis. Firstly, a hyperthyroidism mice model was induced via thyroxine (160 mg/kg) and EEP (1, 2, or 4 g/kg) once daily for 2 weeks. Body weight, thyroid-stimulating hormones, and oxidative stress markers were tested. Secondly, EEP regulating the potential genes at transcript level were analyzed. Thirdly, a network pharmacology based on the constituents of EEP identified using UPLC-Q-TOF-MS analysis was adopted. Finally, a joint analysis was performed to identify the key pathway. The results showed that EEP significantly changed the thyroid-stimulating hormones and oxidative stress markers. Meanwhile, RT-qPCR and Western Blotting demonstrated that the mechanism of the antioxidant effect of EEP reversed the mRNA expression of EHHADH, HMGCR and SLC27A2 and the protein expression of FABP and HMGCR in AMPK and PPAR signaling pathways. This study integrates transcriptomics with network pharmacology to reveal the mechanism of ameliorative effect of EEP on hyperthyroidism-induced oxidative stress.