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As a new tumor therapeutic strategy, adaptive therapy involves utilizing the competition between cancer cells to suppress the growth of drug-resistant cells, maintaining a certain tumor burden. However, it is difficult to determine the appropriate time and drug dose. In this paper, we consider the competition model between drug-sensitive cells and drug-resistant cells, propose the problem of drug concentration, and provide two state constraints: the upper limit of the maximum allowable drug concentration and the tumor burden. Using relevant theories, we propose the best treatment strategy. Through a numerical simulation and quantitative analysis, the effects of drug concentrations and different tumor burdens on treatments are studied, and the effects of cell-to-cell competitive advantage on cell changes are taken into account. The clinical dose titration method is further simulated; the results show that our therapeutic regimen can better suppress the growth of drug-resistant cells, control the tumor burden, limit drug toxicity, and extend the effective treatment time. [ABSTRACT FROM AUTHOR]

Although differential evolution (DE) algorithms perform well on a large variety of complicated optimization problems, only a few theoretical studies are focused on the working principle of DE algorithms. To make the first attempt to reveal the function of binomial crossover, this paper aims to answer whether it can reduce the approximation error of evolutionary algorithms. By investigating the expected approximation error and the probability of not finding the optimum, we conduct a case study comparing two evolutionary algorithms with and without binomial crossover on two classical benchmark problems: OneMax and Deceptive. It is proven that using binomial crossover leads to the dominance of transition matrices. As a result, the algorithm with binomial crossover asymptotically outperforms that without crossover on both OneMax and Deceptive, and outperforms on OneMax, however, not on Deceptive. Furthermore, an adaptive parameter strategy is proposed which can strengthen the superiority of binomial crossover on Deceptive. [ABSTRACT FROM AUTHOR]