1. N1-{4-[2-(Methylthio)-1H-imidazol-5-yl]pyridin-2-yl}benzene-1,4-diamine.
- Author
-
El-Gokha, Ahmed, Ansideri, Francesco, Andreev, Stanislav, Schollmeyer, Dieter, Laufer, Stefan, and Koch, Pierre
- Subjects
- *
MITOGEN-activated protein kinases , *SINGLE crystals , *PHENYLENEDIAMINES , *X-ray diffraction - Abstract
The title compound N1-{4-[2-(methylthio)-1H-imidazol-5-yl]pyridin-2-yl}benzene-1,4-diamine (2) was synthesized via nucleophilic aromatic substitution of 2-chloro-4-[2-(methylthio)-1H-imidazol-5-yl]pyridine (3) and p-phenylenediamine under acidic conditions. The synthesized compound 2 was characterized by 1H-NMR, 13C-NMR, MS HPLC, IR and UV-VIS. Additionally, the structure of 2 was confirmed by single crystal X-ray diffraction. Pyridinylimidazole 2 displays moderate affinity towards the c-Jun N-terminal kinase 3 and shows selectivity versus the closely related p38α mitogen-activated protein kinase. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF