1. Cytokine and Cancer Biomarkers Detection: The Dawn of Electrochemical Paper-Based Biosensor
- Author
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Tze Sian Pui, Song Wei Loo, and School of Chemical and Biomedical Engineering
- Subjects
Bioengineering [Engineering] ,Paper ,Computer science ,cancer biomarkers ,02 engineering and technology ,Electrochemical detection ,Review ,Biosensing Techniques ,Electrochemistry ,biosensor ,lcsh:Chemical technology ,01 natural sciences ,Biochemistry ,Electrochemical Detection ,Analytical Chemistry ,Paper based biosensor ,Neoplasms ,Biomarkers, Tumor ,cytokine ,Humans ,lcsh:TP1-1185 ,Electrical and Electronic Engineering ,Paper-based Device ,Instrumentation ,point-of-care device ,010401 analytical chemistry ,technology, industry, and agriculture ,Electrochemical Techniques ,paper-based device ,021001 nanoscience & nanotechnology ,Point of care device ,Atomic and Molecular Physics, and Optics ,Quantitative determination ,0104 chemical sciences ,Point-of-Care Testing ,electrochemical detection ,Cytokines ,Cancer biomarkers ,Biochemical engineering ,0210 nano-technology ,Biosensor - Abstract
Although the established ELISA-based sensing platforms have many benefits, the importance of cytokine and cancer biomarkers detection for point-of-care diagnostics has propelled the search for more specific, sensitive, simple, accessible, yet economical sensor. Paper-based biosensor holds promise for future in-situ applications and can provide rapid analysis and data without the need to conduct in a laboratory. Electrochemical detection plays a vital role in interpreting results obtained from qualitative assessment to quantitative determination. In this review, various factors affecting the design of an electrochemical paper-based biosensor are highlighted and discussed in depth. Different detection methods, along with the latest development in utilizing them in cytokine and cancer biomarkers detection, are reviewed. Lastly, the fabrication of portable electrochemical paper-based biosensor is ideal in deliberating positive societal implications in developing countries with limited resources and accessibility to healthcare services. Ministry of Education (MOE) Published version The authors would like to acknowledge the financial support for this work funded by Singapore Ministry of Education Academic Research Fund Tier 1 (MOE-2018-T1-001-004).
- Published
- 2020