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19 results on '"Amato, Felice"'

2. The Immune Response to SARS-CoV-2 Vaccine in a Cohort of Family Pediatricians from Southern Italy

Author

Cortese, Paolo, primary, Amato, Felice, additional, Davino, Antonio, additional, De Franchis, Raffaella, additional, Esposito, Speranza, additional, Zollo, Immacolata, additional, Di Domenico, Marina, additional, Solito, Egle, additional, Zarrilli, Federica, additional, Gentile, Laura, additional, Cernera, Gustavo, additional, and Castaldo, Giuseppe, additional

Published
2023
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6. Effectiveness of Elexacaftor/Tezacaftor/Ivacaftor Therapy in Three Subjects with the Cystic Fibrosis Genotype Phe508del/Unknown and Advanced Lung Disease

Author

Terlizzi, Vito, primary, Colangelo, Carmela, additional, Marsicovetere, Giovanni, additional, D’Andria, Michele, additional, Francalanci, Michela, additional, Innocenti, Diletta, additional, Masi, Eleonora, additional, Avarello, Angelo, additional, Taccetti, Giovanni, additional, Amato, Felice, additional, Comegna, Marika, additional, Castaldo, Giuseppe, additional, and Salvatore, Donatello, additional

Published
2021
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9. SARS-CoV-2: One Year in the Pandemic. What Have We Learned, the New Vaccine Era and the Threat of SARS-CoV-2 Variants

Author

Scialo, Filippo, primary, Vitale, Maria, additional, Daniele, Aurora, additional, Nigro, Ersilia, additional, Perrotta, Fabio, additional, Gelzo, Monica, additional, Iadevaia, Carlo, additional, Cerqua, Francesco Saverio, additional, Costigliola, Adriano, additional, Allocca, Valentino, additional, Amato, Felice, additional, Pastore, Lucio, additional, Castaldo, Giuseppe, additional, and Bianco, Andrea, additional

Published
2021
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10. SARS-CoV-2 Subgenomic N (sgN) Transcripts in Oro-Nasopharyngeal Swabs Correlate with the Highest Viral Load, as Evaluated by Five Different Molecular Methods

Author

Zollo, Massimo, primary, Ferrucci, Veronica, additional, Izzo, Barbara, additional, Quarantelli, Fabrizio, additional, Domenico, Carmela Di, additional, Comegna, Marika, additional, Paolillo, Carmela, additional, Amato, Felice, additional, Siciliano, Roberto, additional, Castaldo, Giuseppe, additional, and Capoluongo, Ettore, additional

Published
2021
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11. Lung Microbiome in Cystic Fibrosis

Author

Scialo, Filippo, primary, Amato, Felice, additional, Cernera, Gustavo, additional, Gelzo, Monica, additional, Zarrilli, Federica, additional, Comegna, Marika, additional, Pastore, Lucio, additional, Bianco, Andrea, additional, and Castaldo, Giuseppe, additional

Published
2021
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15. Cystic Fibrosis Patients with F508del/Minimal Function Genotype: Laboratory and Nutritional Evaluations after One Year of Elexacaftor/Tezacaftor/Ivacaftor Treatment

Author

Vincenzo Carnovale, Filippo Scialò, Monica Gelzo, Paola Iacotucci, Felice Amato, Federica Zarrilli, Assunta Celardo, Giuseppe Castaldo, Gaetano Corso, Carnovale, Vincenzo, Scialò, Filippo, Gelzo, Monica, Iacotucci, Paola, Amato, Felice, Zarrilli, Federica, Celardo, Assunta, Castaldo, Giuseppe, Corso, Gaetano, Carnovale, V., Scialo, F., Gelzo, M., Iacotucci, P., Amato, F., Zarrilli, F., Celardo, A., Castaldo, G., and Corso, G.

Subjects
lipid profile, inflammation, protein metabolism, General Medicine, cystic fibrosis, CFTR modulators, cystic fibrosi, CFTR modulator
Abstract

The last ten years have been characterized by an enormous step forward in the therapy and management of patients with Cystic Fibrosis (CF), thanks to the development and combination of Cystic Fibrosis Transmembrane Receptor (CFTR) correctors and potentiators. Specifically, the last approved triple combination elexacaftor/tezacaftor/ivacaftor has been demonstrated to improve lung function in CF patients with both homozygous Phe508del and Phe508del/minimal function genotypes. Here we have assessed the effect of elexacaftor/tezacaftor/ivacaftor in patients carrying the Phe508del/minimal function genotype (n = 20) after one year of treatments on liver function and nutrient absorption with a focus on lipid metabolism. We show that weight, BMI, and albumin significantly increase, suggesting a positive impact of the treatment on nutrient absorption. Furthermore, cholesterol levels as a biomarker of lipid metabolism increased significantly after one year of treatment. Most importantly, we suggest that these results were not dependent on the diet composition, possibly indicating that the drug improves the hepatic synthesis and secretion of proteins and cholesterol.

Published
2022
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16. SARS-CoV-2: One Year in the Pandemic. What Have We Learned, the New Vaccine Era and the Threat of SARS-CoV-2 Variants

Author

Maria Vitale, Aurora Daniele, Lucio Pastore, Felice Amato, Francesco Saverio Cerqua, Fabio Massimo Perrotta, Ersilia Nigro, Adriano Costigliola, Giuseppe Castaldo, Monica Gelzo, Valentino Allocca, Filippo Scialò, Andrea Bianco, Carlo Iadevaia, Scialo, F., Vitale, M., Daniele, A., Nigro, E., Perrotta, F., Gelzo, M., Iadevaia, C., Cerqua, F. S., Costigliola, A., Allocca, V., Amato, F., Pastore, L., Castaldo, G., Bianco, A., Scialo, Filippo, Vitale, Maria, Daniele, Aurora, Nigro, Ersilia, Perrotta, Fabio, Gelzo, Monica, Iadevaia, Carlo, Cerqua, Francesco Saverio, Costigliola, Adriano, Allocca, Valentino, Amato, Felice, Pastore, Lucio, Castaldo, Giuseppe, and Bianco, Andrea

Subjects
0301 basic medicine, medicine.medical_specialty, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), COVID19, QH301-705.5, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Coronaviru, Population, coronavirus, Medicine (miscellaneous), ACE2, Review, Disease, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, renin angiotensin aldosterone system, Pandemic, medicine, 030212 general & internal medicine, Biology (General), Intensive care medicine, education, education.field_of_study, business.industry, SARS-CoV-2, kinin-kallikrein system, 030104 developmental biology, business
Abstract

Since the beginning of 2020, the new pandemic caused by SARS-CoV-2 and named coronavirus disease 19 (COVID 19) has changed our socio-economic life. In just a few months, SARS-CoV-2 was able to spread worldwide at an unprecedented speed, causing hundreds of thousands of deaths, especially among the weakest part of the population. Indeed, especially at the beginning of this pandemic, many reports highlighted how people, suffering from other pathologies, such as hypertension, cardiovascular diseases, and diabetes, are more at risk of severe outcomes if infected. Although this pandemic has put the entire academic world to the test, it has also been a year of intense research and many important contributions have advanced our understanding of SARS-CoV-2 origin, its molecular structure and its mechanism of infection. Unfortunately, despite this great effort, we are still a long way from fully understanding how SARS-CoV-2 dysregulates organismal physiology and whether the current vaccines will be able to protect us from possible future pandemics. Here, we discuss the knowledge we have gained during this year and which questions future research should address.

Published
2021

17. Congenital Diarrheal Disorders: An Updated Diagnostic Approach

Author

Felice Amato, Margherita Di Costanzo, Ausilia Elce, Giuseppe Castaldo, Roberto Berni Canani, Gianluca Terrin, Annalisa Passariello, Rossella Tomaiuolo, G., Terrin, Tomaiuolo, Rossella, Passariello, Annalisa, A., Elce, Amato, Felice, M., Di Costanzo, Castaldo, Giuseppe, and BERNI CANANI, Roberto

Subjects
Diarrhea, Pediatrics, medicine.medical_specialty, Digestive System Diseases, molecular analysi, Review, Catalysis, Lipid Metabolism, Inborn Errors, absorption and transport of nutrients and electrolytes, defects of digestion, defects of enterocyte differentiation and polarization, defects of enteroendocrine cells differentiation, defects of modulation of intestinal immune response, molecular analysis, osmotic diarrhea, secretory diarrhea, lcsh:Chemistry, Inorganic Chemistry, Chronic diarrhea, Malabsorption Syndromes, Medicine, Molecular diagnostic techniques, Humans, Physical and Theoretical Chemistry, lcsh:QH301-705.5, Molecular Biology, Spectroscopy, business.industry, defects of enterocyte differentiation, Organic Chemistry, absorption and transport of nutrients and electrolyte, Infant, Newborn, Infant, General Medicine, Osmotic diarrhea, Computer Science Applications, Molecular analysis, Chronic disease, Parenteral nutrition, lcsh:Biology (General), lcsh:QD1-999, Molecular Diagnostic Techniques, Chronic Disease, Malabsorption syndromes, medicine.symptom, business
Abstract

Congenital diarrheal disorders (CDDs) are a group of inherited enteropathies with a typical onset early in the life. Infants with these disorders have frequently chronic diarrhea of sufficient severity to require parenteral nutrition. For most CDDs the disease-gene is known and molecular analysis may contribute to an unequivocal diagnosis. We review CDDs on the basis of the genetic defect, focusing on the significant contribution of molecular analysis in the complex, multistep diagnostic work-up.

Published
2012

18. Insights into Porphyromonas somerae in Bladder Cancer Patients: Urinary Detection by ddPCR.

Author

Russo F, Esposito S, Tripodi L, Pandolfo SD, Aveta A, Amato F, Nardelli C, Imbimbo C, Pastore L, and Castaldo G

Abstract

To date, the increased awareness of the impact of microbes on human health has promoted scientific interest in microbiome studies for diagnostic and therapeutic purposes, revealing correlations between specific taxa and cancer. In particular, numerous species of Porphyromonas have been associated with several types of tumors. Previously, we studied the urobiome using Next-Generation Sequencing (NGS), and found an increase in Porphyromonas somerae in first morning urine of subjects affected by bladder cancer (BCa). Here, we aimed to confirm the presence of P. somerae in BCa patients by using droplet digital Polymerase Chain Reaction (ddPCR), testing a cohort of 102 male subjects over 50 years. Our findings showed a significant increase in P. somerae in the urine of the BCa group within both ddPCR and NGS, and a correlation between the two methods was observed at a statistical level. Moreover, P. somerae's identification with ddPCR confirmed a significant association between this bacterium and the presence of BCa, highlighting its potential role as a biomarker. This allows us to propose the ddPCR as a suitable method for first-stage BCa screening and follow-up.

Published
2024
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19. Comprehensive Molecular Analysis of Disease-Related Genes as First-Tier Test for Early Diagnosis, Classification, and Management of Patients Affected by Nonsyndromic Ichthyosis.

Author

Fioretti T, Martora F, De Maggio I, Ambrosio A, Piscopo C, Vallone S, Amato F, Passaro D, Acquaviva F, Gaudiello F, Di Girolamo D, Maiolo V, Zarrilli F, Esposito S, Vitiello G, Auricchio L, Sammarco E, Brasi D, Petillo R, Gambale A, Cattaneo F, Ammendola R, Nappa P, and Esposito G

Abstract

Inherited ichthyoses are a group of clinically and genetically heterogeneous rare disorders of skin keratinization with overlapping phenotypes. The clinical picture and family history are crucial to formulating the diagnostic hypothesis, but only the identification of the genetic defect allows the correct classification. In the attempt to molecularly classify 17 unrelated Italian patients referred with congenital nonsyndromic ichthyosis, we performed massively parallel sequencing of over 50 ichthyosis-related genes. Genetic data of 300 Italian unaffected subjects were also analyzed to evaluate frequencies of putative disease-causing alleles in our population. For all patients, we identified the molecular cause of the disease. Eight patients were affected by autosomal recessive congenital ichthyosis associated with ALOX12B , NIPAL4 , and TGM1 mutations. Three patients had biallelic loss-of-function variants in FLG , whereas 6/11 males were affected by X-linked ichthyosis. Among the 24 different disease-causing alleles we identified, 8 carried novel variants, including a synonymous TGM1 variant that resulted in a splicing defect. Moreover, we generated a priority list of the ichthyosis-related genes that showed a significant number of rare and novel variants in our population. In conclusion, our comprehensive molecular analysis resulted in an effective first-tier test for the early classification of ichthyosis patients. It also expands the genetic, mutational, and phenotypic spectra of inherited ichthyosis and provides new insight into the current understanding of etiologies and epidemiology of this group of rare disorders.

Published
2024
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