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Background/Objectives: Bimodal stimulation (BS), which combines the use of a cochlear implant (CI) in one ear and a hearing aid (HA) in the opposite ear, is an established strategy to treat hearing loss by exploiting the unique capabilities of each device. CIs stimulate the auditory nerve by bypassing damaged hair cells, while HAs amplify sounds by requiring a functional hearing residual. The aim of this systematic review is to investigate the advantages and disadvantages of BS such as speech perception in noise. Methods: We examined clinical studies published from October 2020 to July 2024, following the PRISMA guidelines, focusing on the advantages and disadvantages of BS on speech perception in noise in adulthood. Results: BS in adult patients significantly improves speech perception in quiet and noisy environments, especially for those with increased residual hearing. Unilateral CIs and BS perform similarly in quiet conditions, but BS significantly improves speech discrimination in noisy environments if loudness between the two devices is appropriately balanced. Conclusions: Directional microphones and programming software are new technologies that succeed in reducing environmental noise and improving verbal perception outcomes, although their features in the literature are controversial. In addition, the individuals using BS may face temporal mismatches mainly due to differing device latencies, affecting sound localization. Compensating for these mismatches can enhance localization accuracy. However, modulated noise remains a significant obstacle to verbal perception in noise. Valuable assessment tools such as music tests provide further information on hearing performance and quality of life. More research is needed to define certain selection criteria.

The Italian sporting event ‘XIV Convittiadi’ involving students at boarding schools took place in Molise region, central Italy, in April 2022. The study describes the public health protocol with specific countermeasures developed for the event, including testing, isolation, and contact tracing during the COVID-19 pandemic, and reports the main related findings. There were 590 Italian white participants, with 514 athletes (mean age 13.6 ± 1.6 years) and 76 accompanying teachers/guardians (50 ± 8.7 years) of 21 boarding schools from different Italian regions. During the event, 1281 antigenic swabs were performed, and twelve COVID-19 cases were promptly identified due to active screening, involving ten (83.3%) athletes and two (16.7%) accompanying teachers. Among the infected athletes, 83.3% complained mild symptoms, either before or after the ascertained positivity, and 40% had received primary cycle vaccination and booster, or only completed the primary course. The enhanced surveillance and contact tracing activities allowed identifying 34 participants as close contacts who were subjected to a daily follow-up that revealed only four (11.8%) as infected. Since in mass gathering events public health risk is not clear and could not be available through the traditional surveillance systems, increased monitoring activities are necessary. The practical approach implemented for this event was valuable for SARS-CoV-2 control and case management either among participants, or the host country population, suggesting its application to other airborne communicable diseases.

Background: Disease trajectories in leukemia are often unpredictable and recurrent, and patients’ experiences can impact their quality of life. Studies in the literature often do not explore gender-related illness experiences from an intersectional approach and throughout the illness trajectory. This comprehensive study aims to explore the full spectrum of experiences lived by women with leukemia throughout the disease trajectory, from diagnosis to treatments and post-stem cell transplant follow-up. Method: A grounded theory approach was meticulously developed to analyze semi-structured interviews with 13 women with leukemia in the post-transplant follow-up phase at a hospital in Northern Italy. The data analysis was an iterative process, conducted concurrently using a constant comparative method. Data collection concluded when data saturation was reached. Results: The core category identified is women’s inner strength during the disease trajectory, which was identified for its recurrence and cross-cutting nature, according to the women. This core category interconnects with five main categories: 1. Facing the disease: Between resistance and surrender. 2. Living for today and moving forward. 3. Unexpected elements in relationships. 4. Changes that shape women. 5. Demystifying the body and embracing ‘diminished beauty’. Conclusions: An explanatory model of the disease trajectory of women with leukemia was defined as: ‘Women with leukemia, between inner strength and fighting prejudice’. An in-depth analysis of the disease experiences revealed aspects that are not easily understood through a purely biological perspective of gender differences, often overlooking the psycho-social and relational peculiarities of women.

Craniosacral rhythm is a manual therapy technique that focuses on the subtle, rhythmic movement of cerebrospinal fluid as it flows through the central nervous system and musculoskeletal system. Through light and delicate manipulation of the cranial bones, membranes and soft tissues of the head and neck, it promotes rebalancing and release from tension in the body, improving the circulation of the cerebrospinal fluid and the individual’s health. In the field of prosthetic dentistry, in rare cases, such as a full arch or removable partial denture, the patient perceives a sensation of constriction even though all procedures have been used correctly. In this work, a new design fora removable partial denture is proposed that does not interfere with the primary respiratory mechanism, reducing the sensation of constriction in the patient. The materials used are the same as those used for a normal removable partial denture, and the technique used is the “lost wax” one: the novelty is that the prosthesis is made in two separate parts that are joined by a central connection; the result is a removable partial denture with a small central thickening in the main joint represented by the connection of the two pieces. Craniosacral breathing movements are favored with this prosthesis as the metal structure is hyperstatic towards intrusion movements, more or less virtual in the opposite direction, i.e., extrusion towards the vestibule.

Introduction: Nailfold video-capillaroscopy (NVC) is a non-invasive cost-effective technique involving the microscopic examination of small blood vessels of the distal nailfold with a magnification device. It provides valuable information regarding the microcirculation including anomalies such as tortuous or dilated capillaries, hemorrhages, and avascular areas, which can characterize connective tissue diseases. The utility of NVC in the diagnosis and monitoring of systemic sclerosis (SSc) has been investigated in numerous studies allowing the distinction of the specific microvascular pattern of scleroderma from different conditions other than scleroderma (non-scleroderma pattern). Sarcoidosis (SA) is a systemic inflammatory disease that can affect various organs, including the lungs, skin, and lymph nodes. The purpose of our review was to evaluate the current state of the art in the use of NVC in the diagnosis of SA, to understand the indications for its use and any consequent advantages in the management of the disease in different settings in terms of benefits for patients. Materials and Methods: We searched for the key terms “sarcoidosis” and “video-capillaroscopy” in a computerized search of Pub-Med, extending the search back in time without setting limits. We provided a critical overview of the literature, based on a precise evaluation. After our analysis, we examined the six yielded works looking for answers to our questions. Results: Few studies have evaluated that microcirculation is often compromised in SA, with alterations in blood flow and consequent tissue damage. Discussion: Basing on highlighted findings, NVC appears to be a useful tool in the initial evaluation of sarcoidosis patients. Furthermore, capillaroscopy is useful in the evaluation of the coexistence of sarcoidosis and scleroderma spectrum disorder or overlap syndromes. Conclusions: In conclusions, no specific pattern has been described for sarcoidosis, and further re-search is needed to fully understand the implications of nailfold capillaroscopy find-ings in this disease and to establish standardized guidelines for its use in clinical practice.

Background: Listening difficulties may frequently occur in school settings, but so far there were no tools to identify them for both hearing and hearing-impaired Italian students. This study performed cross-cultural adaptation and validation of the Listening Inventory for Education-Revised for Italian students (LIFE-R-ITA). Methods: The study procedure followed the stages suggested by the Guidelines for the Process of Cross-cultural Adaptation of Self-Report Measures. For the content validation, six cochlear implanted students (8–18 years old) pre-tested the initial version. Whenever any situation did not occur in Italy, the item was adapted to more typical listening situations in Italy. The final version of LIFE-R-ITA was administered to a sample of 223 hearing students from different school settings and educational degrees in order to collect normative data. Results: For the LIFE-R-ITA, hearing students showed an average score of 72.26% (SD = 11.93), reflecting some listening difficulties. The subscales (LIFE total, LIFE class, and LIFE social) indicated good internal consistency. All items were shown to be relevant. Most challenging situations happened when listening in large rooms, especially when other students made noise. LIFE social scores were significantly worse than those of LIFE class (p < 0.001). Conclusions: The present study provides cross-cultural adaptation and validation for the LIFE-R-ITA along with the normative data useful to interpret the results of students with hearing loss. The LIFE-R-ITA may support teachers and clinicians in assessing students’ self-perception of listening at school. Such understanding may help students overcome their listening difficulties, by planning and selecting the most effective strategies among classroom interventions.

Chest trauma is the leading cause of death in people under 40. It is estimated to cause around 140,000 deaths each year. The key aims are to reduce mortality and the impact of associated complications to expedite recovery and to restore patient’s conditions. The recognition of lesions through appropriate imaging and early treatment already in the emergency department are fundamental. The majority can be managed in a non-surgical way, but especially after traumatic cardiac arrest, a surgical approach is required. One of the most important surgical procedures is the Emergency Department Thoracotomy (EDT). The aim of this review is to provide a comprehensive synthesis about the management of thoracic trauma, the surgical procedures, accepted indications, and technical details adopted during the most important surgical procedures for different thoracic trauma injuries. Literature from 1990 to 2023 was retrieved from multiple databases and reviewed. It is also important to emphasize the medico-legal implications of this type of trauma, both from the point of view of collaboration with the judicial authority and in the prevention of any litigation.

Psychological distress is widespread among university students, with depression being notably more prevalent compared to the general population. University counseling services are crucial for addressing these mental health challenges, and numerous studies have demonstrated their effectiveness in reducing psychological distress and improving overall well-being. However, there is limited research on what factors predict the success of university counseling. This study aims to evaluate whether counseling improves well-being, specifically by reducing depressive symptoms, and to explore whether personality traits influence counseling outcomes. Participants included 125 Italian university students (64.8% female, mean age = 22.69; SD = 3.04) who utilized counseling services. They completed a socio-demographic questionnaire, the Beck Depression Inventory-II (BDI-II), and the Personality Inventory for DSM-5-TR (PID-5-TR) at three points: immediately after the intake interview (T0), just before the intervention (T1), and after the fourth session (T2). Linear mixed models were used to analyze changes in depression levels, revealing a significant reduction in depressive symptoms from pre- to post-intervention. Among personality traits, only antagonism showed a significant interaction with time. Additionally, higher detachment scores were associated with higher depression levels. These findings emphasize the need for focused attention on students’ emotional issues and suggest that personality traits may influence the effectiveness of counseling.

Agriculture drones face important challenges regarding autonomy and construction, as flying time below the 9-minute mark is the norm, and their manufacture requires several tests and research before reaching proper flight dynamics. Therefore, correct design, analysis, and manufacture of the structure are imperative to address the aforementioned problems and ensure a robust build that withstands the tough environments of this application. In this work, the analysis and implementation of a Nylamid motor bracket, aluminum sandwich-type skeleton, and carbon fiber tube arm in a 30 kg agriculture drone is presented. The mechanical response of these components is evaluated using the finite element method in ANSYS Workbench, and the material behavior assumptions are assessed using a universal testing machine before their implementations. The general description of these models and the numerical results are presented. This early prediction of the behavior of the structure allows for mass optimization and cost reductions. The fast dynamics of drone applications set important restrictions in ductile materials such as this, requiring extensive structural analysis before manufacture. Experimental and numerical results showed a maximum variation of 8.7% for the carbon fiber composite and 13% for the Nylamid material. The mechanical properties of polyamide nylon allowed for a 51% mass reduction compared to a 6061 aluminum alloy structure optimized for the same load case in the motor brackets design. The low mechanical complexity of sandwich-type skeletons translated into fast implementation. Finally, the overall performance of the agriculture drone is evaluated through the data gathered during the flight test, showing the adequate design process.

This research focuses on integrating seakeeping indices into the trajectory planning of a mother ship in order to minimize risks during UAV (unmanned aerial vehicle) takeoff and landing in challenging sea conditions. By considering vessel dynamics and environmental factors, the proposed trajectory planning algorithm computes optimal paths that prioritize the stability and safety of the ship, mitigating the impact of adverse weather on UAV operations. Specifically, the new adaptive weather routing model presented is based on a genetic algorithm. The model uses the previously evaluated response amplitude operators (RAOs) for the reference ship at different velocities and encounter angles, along with weather forecast data provided by the global wave model (GWAM). Preliminary evaluations confirm the effectiveness of the presented model in significantly improving the reliability of autonomous UAV operations from a mother ship across all encountered sea state conditions, particularly when compared with a graph-based solution. The current results clearly demonstrate that it is possible to achieve appreciable improvements in ship seakeeping performance, thereby making UAV-related operations safer.

(1) Objectives: The purpose of this review was to compare the effects of combining skeletal anchorage and Class II devices, both from an overall perspective and individually for each type of appliance, considering as main outcomes the vertical dimensions and the inclination of the mandibular and maxillary incisors. (2) Materials and Methods: A search without time restrictions was performed up to February 2024 in PubMed, PubMed Central, Scopus, and Medline for randomized controlled trials, as well as prospective and retrospective cohort studies, considering Class II patients treated with and without skeletal anchorage. The effect measure used for the meta-analytic evaluation was the standardized mean difference (SMD). The SMD calculation was obtained by subtracting the mean values of T1–T0 for each individual treatment and then calculating the SMD between the treatments involved. The meta-analysis was performed using the standardized mean difference of the mean difference of the T1–T0 change in the outcome between the different treatments evaluated as the effect size. (3) Results: A total of 1217 documents were initially retrieved. According to the PRISMA protocol, 18 studies comparing different skeletal anchorage protocols (upper/lower miniscrews and miniplates), combined with four appliances (Herbst, Forsus, Carriere Motion, and elastics), were included in the analysis. No significant difference in skeletal divergence was found between groups from an overall point of view (SMD: 0.19 (−0.48 to 0.83) according to the random-effects model). A statistically significant reduction in IMPA° was found in patients treated with temporary anchorage devices (TADs) (SMD of 5.58 (3.40 to 7.75)), except for the elastics group (SMD: 3.76 (−0.91 to 8.43)). The effect on the upper incisors’ inclination appeared to be strictly dependent on the type of anchorage (TADs in one or both of the arches). Some limitations must be considered when interpreting the results: the small number of studies included and the heterogeneity among them are among the limitations, and the temporal disparity among some studies; the ages of the patients were not always comparable; and, finally, the clinical relevance of the effects of TADs is sometimes questionable. (4) Conclusions: The vertical dimension seems not to be significantly affected by skeletal anchorage; instead, the proclination of mandibular incisors is generally reduced when TADs are used. Skeletal anchorage might be useful if lingual tipping of the upper incisors is required; however, it is influenced by the anchorage protocol.

Background: Chemsex has been defined as the deliberate use of drugs for prolonged sexual intercourse between gay and bisexual men and other men who have sex with men (MSM). Drugs associated with chemsex can trigger mental health problems such as anxiety, depression, risk of psychosis and suicidal ideation, social isolation, stigmatization, and even loss of impulse control and lack of coping strategies. Currently, the increase in illicit drugs in a sexual context is considered an outbreak of a public health emergency. Objective: The aim of this study is the construction and validation of the Chem-Sex Inventory (CSI), a new scale to assess the mental health risk of chemsex behaviors. Methods: A cross-sectional design was conducted to study 563 participants. Data were collected through an online questionnaire between January and April 2023, and the construct validity of the CSI was assessed through exploratory and confirmatory factor analysis. Results: The sample was, on average, 36 years old (SD: ±9.2). The majority of gender identity was cisgender (97.7%). A factor structure was found that can be summarized in four dimensions: emotional instability, risk of psychosis, altered body perception, and risk of suicide. The confirmatory factor analysis (CFA) presents adequate reliability values, with a Cronbach’s alpha above 0.87 for all dimensions and a McDonald’s omega above 0.88 with a good fit of the 42 items. Conclusions: Our study has shown that the Chem-Sex Inventory (CSI) scale has factorial validity and could be used in clinical practice and research to measure the behavioral contribution of the chemsex phenomenon in MSM.

In recent years, there has been an increase in the practice of chemsex, which is becoming an increasingly serious public health problem. The complex interaction between chemsex and mental health underscores the need to understand the psychological, social, and environmental factors that influence this practice. Methods: A qualitative descriptive phenomenological study was conducted in the community of Madrid, Spain to explore the depth of the chemsex phenomenon through a thematic analysis. Between April and June 2024, interviews were conducted with 15 MSM (gay, bisexual, and other men who have sex with men) who participate in these practices, using purposive and snowball sampling. Results: three main themes were identified, namely, (T1) contextualization of the practice, (T2) factors associated with chemsex, and (T3) strategies and interventions for risk and harm reduction. Conclusion: Chemsex is a phenomenon that combines sexual practices with substance use in complex social environments, presenting significant risks to physical, mental, and sexual health. It is necessary to implement public health interventions to mitigate these risks.

Background: Amidst current misinformation, media literacy is an essential competency for nursing professionals. This study aimed to analyze the level of media health literacy among Spanish undergraduate nursing students, stratifying the results by gender, region, and other associated factors. Methods: A cross-sectional study was conducted at five Spanish universities (N = 416) using the Spanish version of the Media Health Literacy (MeHLit-SV) Questionnaire. Results: Students presented an average media health literacy score of 48.73 points. The media health literacy level was significantly higher among students from universities in the central and northeastern regions of Spain (ANOVA Test, p = 0.0002), those who had previously studied in a city (ANOVA Test, p = 0.001), those who combined their studies with employment (ANOVA Test, p = 0.001), and those residing in communities with fewer than 500 inhabitants (ANOVA Test, p = 0.001). No differences were found based on gender. Conclusions: The media health literacy level of the students was deficient and varied according to socio-economic and socio-educational factors. Understanding the literacy level of future nurses and promoting the inclusion of this competency in their education will enable them to become leaders in improving the population’s health self-care.

Suicidal ideation is a process that is intertwined with suicidal behavior. It begins with the formation of an idea about whether it is worth continuing to live, an idea that can evolve and trigger a series of actions ranging from planning to the execution of the suicidal act. This is a descriptive observational study based on numerical measurements with its respective statistical analysis that established the behavioral patterns of the phenomenon studied. The research proposal was approved by the research committee of the Faculty of Medicine and Surgery, URSE; data collection was performed through the instruments: Beck Suicidal Ideation Scale, Beck Depression Inventory, Abbreviated Scale of School Bullying Questionnaire, Drug Dependence Identification Questionnaire, and Family Apgar. The prevalence of suicidal ideation was 5.4%; 19.7% of the medical students have been victims of bullying in any form; 22.2% reported regular use of alcohol, tobacco, drugs, and other addictive substances; in addition, 17.7% had mild family dysfunction, moderate in 9.9% and severe with 15.3%; depression was recorded to a mild degree with 6.4%, followed by moderate in 1.5% of cases. Suicidal ideation among medical students is of concern; these problems must be addressed comprehensively, promoting a supportive environment that promotes the mental health and well-being of medical students.

Twenty-four ewes (eight fistulated in the rumen) were assigned to a 2 × 2 factorial design. The treatments included the pasture grazed (natural mixed swards—NMS or cultivated monophytic (Brachiaria brizantha cv. Marandu) swards—CMS) and the level of supplementation: without supplement or with a 1% supplement (dry matter (DM)/live weight). The supplement included one-third endosperm expeller (ENE) and two-thirds mesocarp expeller (ME) from Acrocomia aculeata (Jacq.) Lodd. ex Mart. In sacco rumen degradation of ENE, ME, NMS, and CMS was assessed in fistulated sheep, as were rumen fermentation variables. Average daily gain (ADG) was assessed in non-fistulated animals during a 7-week period. Potential degradability of the DM and crude protein of the expellers was not affected by the type of pasture grazed or the level of supplementation (p > 0.05), but the fractional rate of degradation (c) of DM was three times faster (p < 0.01) for ME than for ENE. The potential degradability of neutral detergent fiber was 34% higher (p < 0.0001) for ENE, with no differences in c (p > 0.1). Supplementation slowed down the c of the DM of the pastures, especially in animals grazing NMS (24% lower). Treatments affected rumen pH, concentration of volatile fatty acids, and proportion of valerate, in different ways. The use of the supplement increased ADG of sheep (six-fold in sheep grazing NMS and 40% in those grazing CMS). The use of a mixture of one-third ENE plus two-thirds ME as a protein supplement in sheep grazing either multi-species natural pastures or monophytic swards of Brachiaria brizantha cv. Marandu slows down the fractional rate of degradation of the pastures, the effect of which is more intense in animals grazing natural swards. This supplementation also increases average daily gain, more substantially with multi-species natural pastures.

The existing literature on sexual consent is extensive, but a new social approach to this topic is emerging, necessitating further research. This article addresses a gap in understanding how men’s interactions with other men, who are not their sexual partners, both before and during sexual encounters, influence their approach to consent beyond sexual cues. The study involved sixteen interviews and two focus groups with men aged 18–25. Conducted within the framework of the Consent project (PID2019-110466RB-100), this research aims to analyze how communicative acts, beyond verbal exchanges, shape relationships where either consent or coercion prevails. The findings reveal that when men engage in coercive interactions with non-sexual male peers, these interactions can encourage the violation of consent in their sexual relationships. Conversely, some men reject this coercive behavior, take a stand, and support others in avoiding situations that compromise consent. These results underscore the importance of addressing norms of masculinity and male interactions to ensure that all individuals can autonomously make decisions about their sexual lives.

Due to the escalating network throughput and security risks, the exploration of intrusion detection systems (IDSs) has garnered significant attention within the computer science field. The majority of modern IDSs are constructed using deep learning techniques. Nevertheless, these IDSs still have shortcomings where most datasets used for IDS lies in their high imbalance, where the volume of samples representing normal traffic significantly outweighs those representing attack traffic. This imbalance issue restricts the performance of deep learning classifiers for minority classes, as it can bias the classifier in favor of the majority class. To address this challenge, many solutions are proposed in the literature. TDCGAN is an innovative Generative Adversarial Network (GAN) based on a model-driven approach used to address imbalanced data in the IDS dataset. This paper investigates the performance of TDCGAN by employing it to balance data across four benchmark IDS datasets which are CIC-IDS2017, CSE-CIC-IDS2018, KDD-cup 99, and BOT-IOT. Next, four machine learning methods are employed to classify the data, both on the imbalanced dataset and on the balanced dataset. A comparison is then conducted between the results obtained from each to identify the impact of having an imbalanced dataset on classification accuracy. The results demonstrated a notable enhancement in the classification accuracy for each classifier after the implementation of the TDCGAN model for data balancing.

This study investigates the enhanced production of key therapeutic metabolites (ellagic acid, serotonin, and chlorogenic acid) in response to abiotic stress in in vitro cultures of Quercus suber somatic embryos. Findings indicate significant increases in metabolite levels under various stress conditions, highlighting the potential for commercial-scale production of these compounds, known for their antioxidant, anticancer, and anti-COVID-19 properties. Under osmotic/saline stress, ellagic acid production significantly increased, representing an 80% increase compared to control conditions. In embryos exposed to different stressors, serotonin accumulation showed a six-fold increase under osmotic/saline stress. Although the elicitors used did not increase chlorogenic acid levels, exploring alternative stress types may enhance its production. This research paves the way for sustainable, large-scale production of health-beneficial metabolites, addressing global health challenges and promoting resource sustainability.

Patellar sleeve fractures, though relatively rare, present unique challenges in diagnosis and management. This review aims to provide a comprehensive overview of the current understanding of patellar sleeve fractures, focusing on their epidemiology, clinical presentation, imaging, and management strategies. Epidemiologically, these fractures are uncommon, representing approximately 1% of all fractures in pediatric patients, yet they account for 50% of all patella fractures in this population. They predominantly affect adolescents, with a peak incidence around 12.7 years of age, and are more common in boys, occurring at a ratio of 3 to 5:1. Understanding these demographic patterns is crucial for early recognition and appropriate management. Clinically, patellar sleeve fractures typically present with the sudden onset of severe pain, often associated with explosive activities such as jumping. However, diagnosis can be challenging, particularly in cases with minimal displacement or where alternative muscle groups compensate for the injury. Differential diagnosis is essential, and clinicians should be vigilant for signs such as palpable gaps at the lower pole of the patella and patella alta. Imaging modalities play a vital role in diagnosis, with plain X-rays often revealing no bony damage. Ultrasonography may offer a cost-effective alternative, especially in cases where radiographic findings are inconclusive. Advanced imaging techniques such as MRI can assist in characterizing the extent of the injury and assessing for associated complications. Management strategies encompass a spectrum of approaches, ranging from conservative measures such as immobilization and physical therapy to surgical interventions, including open reduction and internal fixation or arthroscopic surgery. The choice of treatment depends on various factors, including the fracture pattern, displacement, patient age, activity level, and associated injuries. Despite advancements in diagnosis and treatment, the optimal management of patellar sleeve fractures remains a clinical challenge. Further research is warranted to elucidate optimal algorithms for diagnosis and treatment, with the ultimate goal of improving outcomes and reducing the risk of long-term complications associated with this rare but clinically significant knee injury.

Thoracic outlet syndrome (TOS) is a group of symptoms caused by the compression of neurovascular structures of the superior thoracic outlet. The knowledge of its clinical presentation with specific symptoms, as well as proper imaging examinations, ranging from plain radiographs to ultrasound, computed tomography and magnetic resonance imaging, may help achieve a precise diagnosis. Once TOS is recognized, proper treatment may comprise a conservative or a surgical approach.

Early soybean yield estimation has become a fundamental tool for market policy and food security. Considering a heterogeneous crop, this study investigates the spatial and spectral variability in soybean canopy reflectance to achieve grain yield estimation. Besides allowing crop mapping, remote sensing data also provide spectral evidence that can be used as a priori knowledge to guide sample collection for prediction models. In this context, this study proposes a sampling design method that distributes sample plots based on the spatial and spectral variability in vegetation spectral indices observed in the field. Random forest (RF) and multiple linear regression (MLR) approaches were applied to a set of spectral bands and six vegetation indices to assess their contributions to the soybean yield estimates. Experiments were conducted with a hyperspectral sensor of 25 contiguous spectral bands, ranging from 500 to 900 nm, carried by an unmanned aerial vehicle (UAV) to collect images during the R5 soybean growth stage. The tests showed that spectral indices specially designed from some bands could be adopted instead of using multiple bands with MLR. However, the best result was obtained with RF using spectral bands and the height attribute extracted from the photogrammetric height model. In this case, Pearson’s correlation coefficient was 0.91. The difference between the grain yield productivity estimated with the RF model and the weight collected at harvest was 1.5%, indicating high accuracy for yield prediction.

Chronic lymphocytic leukemia (CLL) is a distinct category of lymphoproliferative disorder characterized by the clonal expansion of mature B cells, followed by their accumulation in primary and secondary lymphoid organs. Cluster of differentiation (CD) markers such as CD79b, CD45, CD23, CD22 and CD81 serve as reliable prognostic indicators in CLL as well as the human leukocyte antigen (HLA) with its well-documented associations with various cancers. This study aims to investigate, for the first time, potential connections between HLA typing and CD marker expression in CLL. Although it is one of the most prevalent neoplasms, there is a need for biomarkers that can improve survival. This study included 66 CLL patients and 100 controls, with all samples analyzed using biochemical methods, flow cytometry, and cytomorphology. Next-generation sequencing was performed for HLA typing. The results indicate that several CD markers are statistically associated with different HLA alleles, specifically CD45 with HLA-C*07:01:01; CD79b with HLA-DPA1*02:01:02; CD23 with HLA-B*39:01:01; CD22 with HLA-B*49:01:01, HLA-C*07:01:01, HLA-DPB1*02:01:02, and HLA-DRB1*07:01:01; and CD81 with HLA-DPB1*04:02:01, HLA-DQA1*01:04:01, and HLA-DQB1*05:03:01. In conclusion, this research demonstrates significant statistical links between HLA genes and immunophenotypic markers in CLL patients, shedding new light on the immunological context of CLL.

Ischemic preconditioning (PC) induced by a sub-lethal cerebral insult triggers brain tolerance against a subsequent severe injury through diverse mechanisms, including the modulation of the immune system. Tumor necrosis factor (TNF)-α-stimulated gene 6 (TSG-6), a hyaluronate (HA)-binding protein, has recently been involved in the regulation of the neuroimmune response following ischemic stroke. Thus, we aimed at assessing whether the neuroprotective effects of ischemic PC involve the modulation of TSG-6 in a murine model of transient middle cerebral artery occlusion (MCAo). The expression of TSG-6 was significantly elevated in the ischemic cortex of mice subjected to 1 h MCAo followed by 24 h reperfusion, while this effect was further potentiated (p < 0.05 vs. MCAo) by pre-exposure to ischemic PC (i.e., 15 min MCAo) 72 h before. By immunofluorescence analysis, we detected TSG-6 expression mainly in astrocytes and myeloid cells populating the lesioned cerebral cortex, with a more intense signal in tissue from mice pre-exposed to ischemic PC. By contrast, levels of TSG-6 were reduced after 24 h of reperfusion in plasma (p < 0.05 vs. SHAM), but were dramatically elevated when severe ischemia (1 h MCAo) was preceded by ischemic PC (p < 0.001 vs. MCAo) that also resulted in significant neuroprotection. In conclusion, our data demonstrate that neuroprotection exerted by ischemic PC is associated with the elevation of TSG-6 protein levels both in the brain and in plasma, further underscoring the beneficial effects of this endogenous modulator of the immune system.

In the present study, XRD, SEM/EDS, Raman, EMR/EPR spectroscopy, and vibrating sample magnetometry (VSM) were used to analyze the reduction of hematite by the carbonization products of waste activated sludge (WAS) at 500–1000 °C. The reduction process includes the following steps: α-Fe2O3 → Fe2O3 + Fe3O4 (Ttr~500 °C) → Fe3O4 (Ttr~600–700 °C) → FeO → Feamorph. (Ttr~1000 °C). The prevalence of certain phase compositions at different hematite reduction temperatures makes it possible to predict the areas viable for the application of reduced oxides: adsorbents (after Ttr~500 °C) → soft ferromagnetic materials (after Ttr~600–700 °C) → electrically engineered amorphous iron (after Ttr~1000 °C).

Background: Differentiated thyroid carcinoma (DTC), mainly papillary (PTC), at low risk of recurrence is currently managed with active surveillance strategies or less aggressive surgeries. However, total thyroidectomy with 131I treatment is still performed both if these tumors are diagnosed before or occasionally after surgery. This real-life study aimed to evaluate the rate of biochemical, structural, and functional events in a large series of consecutive DTCs at low risk of recurrence treated by total thyroidectomy, but not with 131I, in a medium–long-term follow-up. Patients and Methods: We evaluated clinical–pathologic data of 383 consecutive patients (2006–2012) with unifocal DTC [T1a/b(s)] at low risk of recurrence, treated with total thyroidectomy but without lymph node dissection and 131I treatment after surgery. We evaluated if structural, biochemical, and functional events were detected during the follow-up. Results: Females accounted for 75.7% of our study group, and the median age was 50 years. The median tumor dimension was 0.4 cm (range 0.1–1.2). Most of the patients had a unifocal T1a tumor (98.9%), and 73.6% had a classic variant of PTC. We divided the patients according to the absence (group A—n = 276) or presence (group B—n = 107) of interfering TgAb at first control after surgery. After a median follow-up of 10 years, no structural events were detected. Sixteen out of three hundred and eighty-three (4.2%) patients developed biochemical events: 12/276 (4.3%) in group A and 4/107 (3.7%) in group B. The median time elapsed from surgery to detecting a biochemical event was 14.5 and 77.5 months in groups A and B, respectively. No patients performed additional treatments and were followed up with an active surveillance strategy. Conclusions: This study confirmed that patients with DTC at low risk of recurrence showed an excellent outcome in a medium long-term follow-up since no structural events were diagnosed. Significant variations in Tg/TgAb were detected in a few cases, all managed with an active surveillance strategy without the need for other treatments. Therefore, a relaxed follow-up with neck ultrasound and Tg/TgAb measurement is enough to early identify those very unusual cases of recurrence.

The aim of the present study was to evaluate the safety and efficacy of radionuclide therapy with [177Lu]Lu-DOTA-TATE according to our single center experience at the University of Naples Federico II. For the present analysis, we considered 21 patients with progressive, advanced, well-differentiated G1 and G2 in patients with gastro-entero-pancreatic (GEP) neuroendocrine tumors (NETs) treated with [177Lu]Lu-DOTA-TATE according to the decisions of a multidisciplinary team. All patients underwent four cycles of 7–8 GBq of [177Lu]Lu-DOTA-TATE every 8 weeks. A whole-body scan (WBS) was performed 4, 48, and 168 h after each treatment. The dosimetry towards the organ at risk and target lesions was calculated. For each patient, renal and bone marrow parameters were evaluated before, during, and 3 months after the end of the treatment. Follow-up data were obtained and RECIST criteria were considered as the endpoint. Among 21 patients enrolled (mean age 65 ± 9 years); 17 (81%) were men and the small intestine was the most frequent location of disease (n = 12). A mild albeit significant variation (p < 0.05) in both platelets and white blood cell counts among all time points was observed, despite it disappearing 3 months after the end of the therapy. According to the RECIST criteria, 11 (55%) patients had a partial response to therapy and 8 (40%) had stable disease. Only one (5%) patient had disease progression 4 months after treatment. Our data confirm that [177Lu]Lu-DOTA is safe and effective in controlling the burden disease of G1/G2 GEP-NETs patients.

Earth data is essential for global environmental studies. Many Earth data types are naturally modeled by multidimensional arrays (tensors). Array (Tensor) DBMSs strive to be the best systems for tensor-related workloads and can be especially helpful for Earth data engineering, which takes up to 80% of Earth data science. We present a new quantum Array (Tensor) DBMS data model and new quantum approaches that rely on the upcoming quantum memory and demonstrate exponential speedups when applied to many of the toughest Array (Tensor) DBMS challenges stipulated by classical computing and real-world Earth data use-cases. We also propose new types of charts: Quantum Gantt (QGantt) Charts and Quantum Network Diagrams (QND). QGantt charts clearly illustrate how multiple operations occur simultaneously across different data items and what are the input/output data dependencies between these operations. Unlike traditional Gantt charts, which typically track project timelines and resources, QGantt charts integrate specific data items and operations over time. A Quantum Network Diagram combines several QGantt charts to show dependencies between multistage operations, including their inputs/outputs. By using a static format, QGantt charts and Quantum Network Diagrams allow users to explore complex processes at their own pace, which can be beneficial for educational and R&D purposes.

Background: The prevalence of type 2 diabetes mellitus (T2DM) has been steadily increasing over the past few decades, largely due to the rise in obesity rates. Bariatric surgery is a gastrointestinal surgical treatment focused on achieving weight loss in individuals with obesity. A more recent and growing body of literature has shown that improvements in glycemic control and insulin sensitivity and even the remission of T2DM can be seen in patients with obesity and T2DM (“diabesity”), before significant weight loss is achieved, justifying the modification of the terminology from bariatric to metabolic and bariatric surgery (BMS). Main Results: This narrative review provides an overview of the latest literature on BMS for diabesity, discussing key publications and exploring controversial and diverging hypotheses. Robust scientific evidence supporting the use of BMS as a treatment for diabesity has been garnered and new venues are being explored, suggesting the novel and complementary role of the latest generation of incretin-based pharmacotherapy. Conclusions: BMS has emerged as a valuable treatment option for patients with diabesity, offering significant improvements in glycemic control, weight loss, and overall health. The limitations of the currently available and reviewed literature include the flawed knowledge of the mechanisms of action and long-term effects of BMS for the treatment of diabesity. Further studies are also warranted to refine the patient selection criteria and optimal surgical techniques and to evaluate the impact of surgery on T2DM outcomes in diverse populations. Lastly, there is a scarcity of studies investigating the efficacy of BMS against incretin-based pharmacotherapy. The non-systematic, narrative nature of this review and its implicit subjective examination and critique of the body of literature are to be considered additional and intrinsic limitations.

International research attention on evacuation issues has increased significantly following the human and natural disasters at the turn of the century, such as 9/11, Hurricane Katrina, Cyclones Idai and Kenneth, the Black Saturday forest fires and tsunamis in Japan. The main problem concerning when a disaster can occur involves studying the risk reduction. Risk, following all the theoretical and experimental studies, is determined by the product of three components: occurrence, vulnerability and exposure. Vulnerability can be improved over time through major infrastructure actions, but absolute security cannot be achieved. When the event will occur with certainty, only exposure remains to reduce the risk to people before the effect hits them. Exposure can be improved, under fixed conditions of occurrence and vulnerability, by improving evacuation. The main problem in terms of evacuating the population from an area is the available transport system, which must be used to its fullest. So, if the system is well managed, the evacuation improves (shorter times), meaning the exposure is reduced, and therefore, the risk is reduced. A key factor in the analysis of transport systems under emergency conditions is the behavior of the user, and therefore, the study of demand. This work identifies the main research lines that are useful for studying demand under exposure-related risk conditions. The classification of demand models that simulate evacuation conditions in relation to the effect on the transportation system is summarized. The contribution proposes a model for updating choice in relation to emergency conditions and utility. The contribution of emerging ICTs to actualization is formally introduced into the models. Intelligent technologies make it possible to improve user decisions, reducing exposure and therefore risk. The proposed model moves within the two approaches of the literature: it is an inter-period dynamic model with the probability expressed within the discrete choice theory; furthermore, it is a sequential dynamic model with the probability dependent on the previous choices. The contribution presents an example of application of the model, developing a transition matrix considering the case of choice updating under two extreme conditions.

In slopes where high pore water pressure exists, deep counterfort drains (also called drainage trenches or trench drains) represent one of the most effective methods for improving stability or mitigating landslide risks. In the cases of deep or very deep slip surfaces, this method represents the only possible intervention. Trench drains can be realized by using panels or secant piles filled with coarse granular material or permeable concrete. If the trenches are adequately “socket” into the stable ground (for example sufficiently below the sliding surface of a landslide or below the critical slip surface of marginally stable slopes) and the filling material has sufficient shear strength and stiffness, like porous concrete, there is a further increase in shear strength due to the “shear keys” effect. The increase in shear strength is due both to the intrinsic resistance of the concrete on the sliding surface and the resistance at the concrete–soil interface (on the lateral surface of the trench). The latter can be very significant in relation to the thickness of the sliding mass, the “socket depth”, and the spacing between the trenches. The increase in shear strength linked to the “shear keys effect” depends on the state of the porous concrete–soil interface. For silty–clayey base soils, it is very significant and is of the same order of magnitude as the increase in shear resistance linked to the permanent reduction on the slip surface in pore water pressure (draining effect). This paper presents the results of an experimental investigation on the shear strength at the porous interface of concrete and fine-grained soils and demonstrates the high significance and effectiveness of the “shear keys” effect.

In light of current risks and environmental impacts, HBIM (historic building information modeling) offers a highly efficient and interactive method for managing historical data and representing the current states of ancient clay structures. In this study, traditional geodetic techniques were employed to digitally locate a structure without compromising its topographic information to create an accurate model. Tools such as total stations, GNSS receivers, and UAVs were utilized to generate detailed topography of the study site and its surroundings. An ontology-based data management structure was also developed to store historical data and site intervention projects, adhering to the ISO 12006-2 standard. This was achieved through automated scripts in Dynamo softwarev.2.18.1. A comparison between the point cloud (279 images) and total station data (600 points) revealed a georeferencing accuracy difference of +/−0.003 m. Consequently, the developed methods can effectively represent similar structures digitally. The proposed ontological structure facilitates automated storage of internal and external information.

Chemical desiccation is widely used in agriculture to anticipate harvest and mitigate the effects of adverse environmental conditions. It is applied to both grains and seeds. Although this practice is widely used, there are still significant gaps in understanding the effects of different herbicide application times on seed quality and plant physiological responses. The objective of this study was to evaluate the effects of different herbicide application times on cowpea, focusing on seed quality, physiological responses, and biochemical composition, including chlorophylls, carotenoids, sugars, and proline, under nocturnal desiccation. In the first experiment, eight herbicides and two mixtures were applied at night: diquat, flumioxazin, diquat + flumioxazin, glufosinate ammonium, saflufenacil, carfentrazone, diquat + carfentrazone, atrazine, and glyphosate. All of the tested herbicides caused a reduction in normal seedling formation, with the diquat + carfentrazone combination resulting in 100% abnormal seedlings. A significant decrease in chlorophyll levels (chlorophyll a: 63.5%, chlorophyll b: 50.2%) was observed using diquat, which indicates damage to photosynthetic processes, while the carotenoid content increased. Total soluble sugars and proline were also negatively impacted, reflecting physiological stress and metabolic changes in seedlings. In the second experiment, three application times were tested with diquat, diquat + flumioxazin, and diquat + carfentrazone. Nocturnal application showed the most significant reduction in chlorophyll levels and increased carotenoid levels. Application at noon and late afternoon also significantly changed the soluble sugar and proline levels. These results indicate that the herbicide application time directly influences the seeds’ physiological quality.

The increasing need for continuous innovation has given rise to a substantial increase in co-creation initiatives. Since the co-creation of value involves customers participating in the creation of product offerings voluntarily and actively, this investigation tries to understand what drives customers to participate in these co-creation initiatives. To do so, this study employs a probabilistic sample of 683 users enrolled in Linux forums for open-source software distributions. The path analysis and bootstrap samples revealed that customers who exhibit a high innate innovativeness and feel that they belong in the online community show a greater motivation towards platform exploration and participation in co-creation. Moreover, the effect of this synergic interaction on their co-creation participation was partially mediated by the normative dimension of their intrinsic motivation, while the hedonic dimension was not a strong predictor of co-creation contributions. This study fills the voids in the existing literature by showcasing the relevance of personal characteristics, beyond individual motivation, in co-creation behavior.

Minicutting has been used for several woody species, presenting greater efficiency than propagation by conventional cutting due to its high yield of propagative material and higher percentage of rooting in minicuttings. This work was carried out to evaluate the efficiency of minicutting techniques for the ‘Bluegem’ blueberry and find the best concentration of IBA for rooting the minicuttings. The minigarden was installed in pots using micropropagated plants. Four collections of minicuttings were carried out between 27 October 2020 and 12 April 2021, and received the following treatments: 0; 2000; 4000; 6000; and 8000 mg L−1 of IBA. The minicutting was carried out in a mist chamber and evaluated after 60 days. The yield of minicuttings increased from the first to the third collection, decreasing in the fourth collection when the plants began to enter dormancy. The rooting of the minicuttings was influenced by the collection time and the application of IBA. Increasing IBA concentration increased the percentage of rooted minicuttings and root dry mass to concentrations close to 5000 mg L−1 on almost all collection dates. High concentrations of IBA reduced the percentage of sprouted minicuttings and leaf retention and increased mortality. It is recommended for the ‘Bluegem’ blueberry minicutting to apply 5000 mg L−1 of IBA.

Low back pain is a health problem that represents the greatest cause of years lived with disability. This research seeks to evaluate the bacterial composition of the intestinal microbiota of two similar groups: one with chronic low back pain (PG) and the control group (CG). Clinical data from 73 participants and bacterial genome sequencing data from stool samples were analyzed. There were 40 individuals in PG and 33 in CG, aged between 20 and 50 years and with a body mass index of up to 30 kg/m2. Thus, the intragroup alpha diversity and intergroup beta diversity were analyzed. The significant results (p < 0.05) showed greater species richness in PG compared to CG. Additionally, a greater abundance of the species Clostridium difficile in PG was found along with 52 species with significantly different average relative abundances between groups (adjusted p < 0.05), with 36 more abundant species in PG and 16 in CG. We are the first to unveil significant differences in the composition of the intestinal bacterial microbiota of individuals with chronic low back pain who are non-elderly, non-obese and without any other serious chronic diseases. It could be a reference for a possible intestinal bacterial microbiota signature in chronic low back pain.

This retrospective analysis at a major Italian university hospital (January 2018–September 2022) assessed the prognostic significance of fever in patients with bloodstream infections (BSIs). Of the 1299 patients with positive blood cultures, a comparison between febrile and afebrile patients at emergency department admission was conducted. This study particularly focused on the mortality rates associated with these two groups. Notably, afebrile patients exhibited a higher mortality rate. The odds ratio for mortality in afebrile patients was significantly higher compared to febrile patients. This suggests that the absence of fever might be an indicator of increased mortality risk, highlighting the complexity of diagnosing bloodstream infections based on fever presence. This study contributes to the understanding of fever as a diagnostic marker in emergency settings.

Objectives: To assess the overall mental health of enucleated or eviscerated patients after high-density porous polyethylene OCULFIT implantation and external prosthesis over a 1-year follow-up. Methods: Patients with an indication of enucleation or evisceration with OCULFIT implantation were included in a prospective study. The patients completed four questionnaires regarding mental health at three different visits (baseline, 3–6 months, and 9–12 months post-surgery). The questionnaires used were the following: SF-12 for multidimensional health-related quality of life (scale 0–100); Rosemberg self-esteem scale (scale 0–40); Patients Health Questionnaire-4 (PHQ-4) (scale 0–6); and a Lifetime Major Depression and Anhedonia questionnaire (categorised in groups with/without symptoms). Results: A total of 33 patients (16 enucleations and 17 eviscerations) were included in the study. The physical domain of the SF-12 questionnaire did not change between visits, but the mental domain significantly improved from the baseline to the last visit (41.71 ± 12.72 vs. 46.80 ± 10.68, p = 0.04). The number of patients with high, moderate, and low self-esteem (Rosemberg scale) was similar between the baseline and the last visit. The depression and anxiety scores of the PHQ-4 were not significantly different among visits. The number of patients with no symptoms (depression or anhedonia) improved from the baseline (42.2%) throughout the follow-up (66.7% at the last visit). Conclusions: OCULFIT orbital implant and external prosthesis placement maintained and/or improved the quality of life related to mental health in eviscerated and enucleated eyes. The number of patients with no symptoms improved from the baseline throughout the follow-up. The patients’ self-esteem was already high before implantation and remained stable over the follow-up.

Background: Temporomandibular disorders (TMDs) represent a prevalent multifactorial condition that impacts a significant portion of the global population. The objective of this study was to employ Fonseca’s questionnaire for an initial assessment of TMDs. Methods: A cross-sectional study was conducted on a sample of 250 undergraduates from the Dental School of the University of Perugia, Italy. The chi-square test, with a significance level set at p < 0.05, was used to evaluate a statistically significant relationship between TMDs and several variables such as gender, age, employed/unemployed, and physically active or not. Results: The data obtained through the questionnaire indicated that a considerable percentage of students (78%) exhibited signs consistent with TMDs. The most frequently reported signs and symptoms included psychological stress (49.6%), dental clenching and grinding (34%), joint clicking (33.6%), frequent headaches (15.2%), and neck pain (23.2%). Notably, when considering moderate to severe symptoms of TMDs, females were more significantly affected than males. Furthermore, factors such as age, employment status, and physical activity did not appear to influence the prevalence of TMDs. Conclusions: The high prevalence of TMDs identified within this young population (university students), as measured by this questionnaire (albeit warranting validation through more rigorous methodologies) underscores the necessity for the implementation of new preventive strategies that specifically address this demographic.

The electrochemical reduction of carbon dioxide (CO2) to methane (CH4) holds tremendous potential in mitigating greenhouse gas emissions and producing renewable fuels. Thus, this review provides a comprehensive overview of the utilization of copper-based metal–organic frameworks (Cu-MOFs) as catalysts for this transformative process. Diverse key aspects of Cu-MOFs that make them ideal candidates for CO2 reduction are discussed, including their high surface areas, tunable pore sizes, and customizable active sites. Furthermore, recent advances in the design and synthesis of Cu-MOFs tailored specifically for enhanced catalytic activity and selectivity towards CH4 production are highlighted. Additionally, mechanistic insights into the CO2 reduction process on Cu-MOF catalysts are examined. Moreover, the recent application of diverse Cu-MOFs and derived materials in electrochemical reduction systems is discussed, and future research directions and potential applications of Cu-MOFs in sustainable energy conversion technologies are outlined. Thus, this review provides valuable insights into the current state of the art and the prospects for utilizing Cu-MOFs as efficient catalysts for the electrochemical conversion of CO2 to CH4, offering a pathway towards a greener and more sustainable energy future.

Leishmaniasis is a neglected disease with a global spread that affects both domestic and wild animals in addition to people. Leishmania donovani is the suspected anthroponotic cause of visceral leishmaniasis (VL) in India, where it is an endemic disease. The reservoir hosts play a crucial role in the life cycle of the Leishmania parasite. The complicated connection between the pathogen, vector, and reservoir exhibits geographical and temporal diversity. Human-to-human and, to a lesser extent, human-to-animal transmission are the principal mechanisms for the maintenance of anthroponotic diseases. A number of animals were examined for the presence of Leishmania parasites and the findings were reviewed in order to examine the role of animal reservoirs in domestic transmission of cutaneous leishmaniasis in endemic regions of India. The analysis objective was to assess the research conducted on domestic animals’ propensity to spread L. donovani in endemic areas, with a particular emphasis on how proximity and animal density may impact the prevalence of human leishmaniasis. Species of the L. donovani complex have distinct enzootic, zoonotic, and anthroponotic life cycles that depend on the environment. The majority of Leishmania spp. are zoonotic, spreading from non-human mammals to humans. Many nations have leishmaniasis as an endemic disease, and the Indian subcontinent (ISC) has an estimated two to three lakh people who are at risk. This systematic review evaluates the gaps in our understanding of disease transmission that contradict conventional wisdom about the reservoir(s) of visceral leishmaniasis and efforts to manage it on the Indian subcontinent. Fundamental concerns in VL epidemiology and ecology will be clarified by a better understanding of L. donovani infection in domestic animals and its transfer to sandflies. A deliberate, systematic search was conducted on PubMed, Science Direct, and Google Scholar using keywords such as “Leishmania donovani”, “zoonotic visceral leishmaniasis”, and “wild animal reservoir for Leishmania donovani”. A total of 530 potentially relevant references were obtained from these databases, and 507 were not considered due to copy avoidance, irrelevant titles, research publications from nations other than India, or modified compositions. Among the remaining 23 investigations, 20 were rejected, and only 3 were included in the present study. Finally, three research papers with 867 goats, 161 cattle, 106 chickens, 26 sheep, three buffaloes, 406 dogs, and 309 rats were reported. Along with these data, studies across Asian and African countries that are considered VL-endemic areas have been discussed. According to the review, goats are the epidemic’s primary host and possible reservoir in several regions of India. In the endemic regions of the disease, some species of rodents, along with the canines, appear to be maintaining the L. donovani transmission cycle.

Background: Moral Distress (MD) is a unique form of distress that occurs when people believe they know the ethically correct action to take but are constrained from doing so. Limited clinical experience and insufficient ethical knowledge contribute to nursing students’ MD, which can potentially cause negative outcomes. The aims of this study are: (1) to describe the MD intensity of nursing students, and (2) to analyze differences and associations between MD intensity and socio-demographic and academic variables. Methods: A cross-sectional study design with a convenience sample of the second, third, and delayed graduation students was included; only students willing to participate and who had attended their scheduled internships in the last six months were eligible for inclusion. To measure the level of MD, we used the It-ESMEE. We collected socio-demographic and academic variables. The data collection occurred from January 2024 to March 2024. Results: The students who adhered to the collection were N = 344. The findings reveal that the students perceived a high level of MD in situations related to clinical internship and class. They perceived higher levels of MD when nursing was not their first career choice, were separated or divorced, did not have children, and were not an employed student. The overall MD score is statistically significantly lower among students who had nursing as their first career choice (β = −0.267, p < 0.05), have children (β = −0.470, p < 0.01), and are employed (β = −0.417, p < 0.01). In contrast, being separated or divorced (β = 0.274, p < 0.01) was associated with a higher MD score. Conclusions: This study has some limitations: data reflect a local context, and the findings may not be generalizable to other regions or educational environments. Additionally, students’ recollections of their experiences could be influenced by the passage of time, and there may be a selection bias since only students willing to participate were included. The findings suggest that nursing education programs should incorporate more robust training in ethical decision-making and stress management to better prepare students for the moral challenges in their professional practice.

(1) Context: Cancer triggers significant changes in family dynamics. It is noteworthy that coping and problem-solving skills, particularly in situations involving cancer in children and adolescents, have not been adequately explored in the context of family adaptation. This study aims to analyze the effectiveness of family interventions in coping to improve problem-solving skills in parents and/or caregivers of children and adolescents during and after oncological treatment. (2) Methods: This is a scoping review following the recommendations of the Joanna Briggs Institute and the Systematic Reviews and Meta-Analyses Extension for Scoping Review (PRISMA-ScR), from 2014 to 2024, in the databases LILACS, CINAHL, SCOPUS, Web of Science, and PUBMED. (3) Results: Forty-five studies were eligible. Coping strategies were categorized as follows: (1) positive attitudes (including a sense of courage and hope, family support to enhance resilience, and future planning), (2) caregiver empowerment (involving acceptance of diagnosis, emotional distancing, and coping through religiosity), and (3) communication skills (encompassing professional communication, horizontal dialogue with healthcare teams, and sincere communication with friends and family). (4) Conclusions: Over time, families develop coping and problem-solving strategies that influence changes in family functioning patterns, aiding them in accepting, reinterpreting, and reframing ideas and feelings associated with neoplasia.

Background: A wide range of conditions, including mixed depressive symptoms, hyperactivity, cognitive impairment (CI) might be expressions of Bipolar Spectrum Disorder (BSD) according to the neo-Kraepelinian perspective, even in advanced age. CI, which has a high prevalence in the elderly population, when it occurs in comorbidity with depression further hinders therapy response and functional ability. The present study aims to explore risk factors associated with CI in elderly individuals experiencing a depressive episode during lockdown a period marked by significant stressors and rhythm disruption. Methods: A case-control study analyzed data from a previous RCT (secondary analyses) on elderly individuals living at home, assessing depressive symptoms, cognitive performance, hyperactivity, and hypertension before (T0) and during lockdown (T1). Results: Participants with lower pre-pandemic cognitive performance were more prone to lockdown depression compared to those with higher baseline function (F = 6.074; p = 0.016). Among those experiencing lockdown depression without prior depression, those with low cognitive performance were more prevalent than the control group without depression (OR = 11.8; p = 0.015). Conclusion: This study highlights a potentially vulnerable subgroup within the elderly population that requires targeted interventions and support during stressful events. Future research should explore the underlying mechanisms linking cognitive decline and depression in older adults, particularly those with a possible bipolar spectrum predisposition.

Background: Metastatic tumors of the oro-facial tissuesare rare, with an incidence ranging between 1% and 8% of all oral malignant tumors. Generally reported with a peak of incidence in the 5–7th decades but possibly occurring at any age, metastases may represent the first sign of an occult cancer or manifest in patients with an already known history of a primary carcinoma, mostly from the lungs, kidney, prostate, and colon/rectum in males, and the uterus, breast, lung, and ovary in females. In the oro-facial tissues, the most involved sites are the oral mucosa, gingiva/jawbones, tongue, and salivary glands. Methods: A broad and deep literature review with a comprehensive analysis of the existing research on oro-facial metastases from renal-cell carcinoma (RCC) was conducted by searching the most used databases, with attention also paid to the clear-cell histological variant, which is the most frequent one. Results: Among the 156 analyzed studies, 206 cases of oro-facial metastases of renal cancer were found in patients with an average age of 60.9 years (145 males, 70.3%; 61 females, 29.6%). In almost 40% of the cases, metastasis represented the first clinical manifestation of the primary tumor, and 122 were histologically diagnosed as clear-cell renal-cell carcinoma (ccRCC) (59.2%). The tongue was involved in most of the cases (55 cases, 26.7%), followed by the gingiva (39 cases, 18.9%), mandible (35 cases, 16.9%), maxilla (23 cases, 11.1%), parotid gland (22 cases, 10.6%), buccal mucosa (11 cases, 5.3%), lips (7 cases, 3.3%), hard palate (6 cases, 2.8%), soft palate, masticatory space, and submandibular gland (2 cases, 0.9%), and lymph nodes, tonsils, and floor of the mouth (1 case, 0.4%). Among the 122 ccRCCs (84 males, 68.8%; 38 females, 31.1%), with an average age of 60.8 years and representing in 33.6% the first clinical manifestation, the tongue remained the most frequent site (31 cases, 25.4%), followed by the gingiva (21 cases, 17.2%), parotid gland (16 cases, 13.1%), mandibular bone (15 cases, 12.2%), maxillary bone (14 cases, 11.4%), buccal mucosa and lips (6 cases, 4.9%), hard palate (5 cases, 4%), submandibular gland and soft palate (2 cases, 1.6%), and lymph nodes, tonsils, oral floor, and masticatory space (1 case, 0.8%). The clinical presentation in soft tissues was mainly represented by a fast-growing exophytic mass, sometimes accompanied by pain, while in bone, it generally presented as radiolucent lesions with ill-defined borders and cortical erosion. Conclusions: The current comprehensive review collected data from the literature about the incidence, site of occurrence, age, sex, and survival of patients affected by oro-facial metastases from renal-cell carcinoma, with particular attention paid to the cases diagnosed as metastases from clear-cell renal-cell carcinoma, which is the most frequent histological variant. Clinical differential diagnosis is widely discussed to provide clinicians with all the useful information for an early diagnosis despite the effective difficulties in recognizing such rare and easily misdiagnosed lesionsTheir early identification represents a diagnostic challenge, especially when the clinical work-up is limited to the cervico–facial region. Nevertheless, early diagnosis and recently introduced adjuvant therapies may represent the key to better outcomes in such patients. Therefore, general guidelines about the clinical and radiological identification of oro-facial potentially malignant lesions should be part of the cultural background of any dentist.

A new monotypic genus of Prodidominae, Paleotoca gen. n., is proposed to include one cave species collected in a paleoburrow and ferruginous caves from Quadrilátero Ferrífero, Minas Gerais, Brazil: Paleotoca diminassp. n. (♂♀). The new genus is closely related to other Neotropical Prodidominae by sharing the classic claw tuft clasper. Paleotoca gen. n. is diagnosed by the absence of a dorsal abdominal scutum, a ventral parallel rows of strong spines on the tibia and metatarsus I–II, a lack of a conductor, a discrete median apophysis on the bulb and a bifid retrolateral tibial apophysis in the male palp, a posterior extension that is beak-shaped, and folds of a copulatory duct ventrally visible in the female epigyne. Like other Prodidominae species from caves, P. diminassp. n. is a troglobitic spider with morphological characteristics that indicate specialization to live in subterranean environments, including reduction in cuticular pigments, eye loss, heavy spination and trichobothria.

High-Static-Low-Dynamic Stiffness (HSLDS) mechanisms exploit nonlinear kinematics to improve the effectiveness of isolators, preserving controlled static deflections while maintaining low natural frequencies. Although extensively studied under harmonic base excitation, there are still few applications considering real seismic signals and little experimental evidence of real-world performance. This study experimentally demonstrates the beneficial effects of HSLDS isolators over linear ones in reducing the vibrations transmitted to the suspended mass under near-fault earthquakes. A tripod mechanism isolator is presented, and a lumped parameter model is formulated considering a piecewise nonlinear–linear stiffness, with dissipation taken into account through viscous and dry friction forces. Experimental shake table tests are conducted considering harmonic base motion to evaluate the isolator transmissibility in the vertical direction. Excellent agreement is observed when comparing the model to the experimental measurements. Finally, the behavior of the isolator is investigated under earthquake inputs, and results are presented using vertical acceleration time histories and spectra, demonstrating the vibration reduction provided by the nonlinear isolator.

Seasonally Dry Tropical Forests (SDTFs) are situated in regions prone to significant water deficits. This study aimed to evaluate and quantify the dynamics and spatial patterns of vegetation and water bodies through the analysis of physical–hydrological indices for a remnant of FTSD between 2013 and 2021. Basal area, biomass, and tree number were monitored in 80 permanent plots located in two areas of an SDTF remnant with different usage histories. To assess vegetation and water resource conditions, geospatial parameters NDVI, NDWIveg, NDWI, and MNDWI were estimated for the period from 2013 to 2021. The observed patterns were evaluated by simple linear regression, principal component analysis (PCA), and principal component regression (PCR). Area 2 presented higher values of basal area, biomass, and number of trees. In area 1, there was an annual increase in basal area and biomass, even during drought years. The NDVI and NDWIveg indicated the vulnerability of vegetation to the effects of droughts, with higher values recorded in 2020. NDWI and MNDWI detected the water availability pattern in the study area. Physical–hydrological indices in the dynamics of tree vegetation in dry forests are influenced by various factors, including disturbances, soil characteristics, and precipitation patterns. However, their predictive capacity for basal area, biomass, and tree number is limited, highlighting the importance of future research incorporating seasonal variability and specific local conditions into their analyses.

Enhancing the degree of polymerization can mitigate the cytotoxic effects of resinous materials, as residual monomers have been identified as a significant contributor to cytotoxicity. Hence, the aim of the current research was to evaluate the influence of preheating self-adhesive cements at 39 °C on cell migration, cytotoxicity, and degree of conversion. RelyX U200, Set PP, and MaxCem Elite were subjected to Fourier Transform Infrared Spectroscopy–Attenuated Total Reflection (FTIR–ATR). Self-adhesive resin cements were applied onto an ATR device, with samples subjected to either heated or room temperature conditions, followed by photoactivation. For the cytotoxicity analysis, extracts (24 h and 7 days) were placed in contact with NIH/3T3 cells. For cell migration, images were captured of each sample until the possible closure of the cleft occurred. A two-way analysis of variance (ANOVA) was conducted to assess the effect of preheating on the degree of conversion and cell viability within the self-adhesive cements tested. A significance level of 5% was set for statistical purposes. In the results of the degree of conversion, preheating did not improve the conversion of cements (p > 0.05). For the 3-(4-5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT), preheating did not improve the results within 24 h, however, it generated positive results within 7 days for the Set PP resin cement (p < 0.05). For cell migration, high rates of cell death were found in all groups. It is concluded that preheating at 39 °C causes a positive effect only in increasing the cell viability of the Set PP resin cement and that both materials analyzed are highly cytotoxic.

Background: The aim of the study was to investigate a series of complete blood cell count-based biomarkers of systemic inflammation as predictors of clinical outcomes in patients who underwent first-line chemoimmunotherapy for advanced NSCLC. Methods: Consecutive patients with pathologically diagnosed stage III/IV NSCLC and PD-L1 < 50% who underwent first-line chemoimmunotherapy were retrospectively enrolled. The clinical outcomes used for biomarker evaluation were Objective Response Rate (ORR) and Overall Survival (OS). Results: Non-responders had significantly higher values of neutrophil to lymphocyte ratio (NLR, median: 5.36; IQR: 2.78–10.82 vs. 3.31; IQR: 2.15–4.12, p = 0.019), neutrophil to monocyte ratio (NMR, median: 14.00; IQR: 8.82–21.20 vs. 9.20; IQR: 7.45–11.20, p = 0.013), and systemic inflammation index (SII, median: 1395; IQR: 929–3334 vs. 945; IQR: 552–1373, p = 0.025), but only NLR and NMR remained independently associated with clinical response in multivariate logistic regression. In the univariate analysis, white blood cells (OR:1.2202; 95% CI: 1.0339–1.4400, p = 0.019), neutrophils (OR:1.2916; 95% CI: 1.0692–1.5604, p = 0.008), NLR (OR:1.3601: 95% CI: 1.0949–1.6896, p = 0.005) and NMR (OR:1.2159; 95% CI: 1.00396–1.4221, p = 0.015) were significantly associated with survival; Cox regression models confirmed that neutrophils, NLR, and MLR were independently associated with survival; NLR, at a cut-off value of 4.0, showed the better AUC (0.749) in predicting OS. Conclusions: Baseline complete blood cell count biomarkers, especially the NLR, can predict clinical outcomes in patients with advanced NSCLC treated with first-line chemoimmunotherapy.